^
    5ms
    Rosai-Dorfman Disease Presenting as a Bone-Destructive Mass in the Maxillary Sinus With Orbital Extension: A Diagnostic and Therapeutic Challenge. (PubMed, Cureus)
    Corticosteroids appear to be an effective treatment option. Early diagnosis and appropriate steroid therapy may lead to excellent outcomes while avoiding overtreatment.
    Journal
    |
    IL2 (Interleukin 2) • CD68 (CD68 Molecule)
    8ms
    Locally advanced maxillary sinus cancer fed from the internal carotid artery. (PubMed, Eur Arch Otorhinolaryngol)
    This study revealed the frequency and prognosis of locally advanced maxillary sinus cancer fed from the ICA. The prognosis was equivalent between cases with or without feeding from the ICA; therefore, it would be considered important to determine the tumor volume for each feeding blood vessel and assess the areas of dual perfusion.
    Journal
    |
    PLAAT3 (Phospholipase A And Acyltransferase 3)
    |
    cisplatin
    9ms
    Functional Evaluation After Maxillectomy and Scapular Free Flap Reconstruction (clinicaltrials.gov)
    P=N/A, N=16, Completed, Hôpital de la Croix-Rousse
    New trial
    10ms
    Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiation therapy for locally advanced maxillary sinus cancer (JCOG1212): final analysis. (PubMed, Int J Clin Oncol)
    The prognosis of RADPLAT was favorable after 5-year follow-up with acceptable late adverse events and low proportion of treatment related death.
    Journal
    |
    PLAAT3 (Phospholipase A And Acyltransferase 3)
    |
    cisplatin
    11ms
    KRT20-/SATB2+/MCPyV+ Sinonasal Merkel Cell Carcinoma: A Detailed Immunohistochemical and In Situ Hybridization Study. (PubMed, Int J Surg Pathol)
    Relevantly, KRT20, KRT5/6, chromogranin A, p40, p63, HMB45, NF, TTF1, TDT (DNTT), PAX5, p16, KIT, as well as high-risk HPV and EBER1/2 (both by ISH), were negative. This report illustrates that a detailed immunohistochemical study, including STAB2 and MCPyV markers, as well as a careful clinical workup, are essential to adequately classify high-grade neuroendocrine carcinomas, especially KRT20-negative MCC.
    Journal
    |
    TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • PAX5 (Paired Box 5) • NCAM1 (Neural cell adhesion molecule 1) • NKX2-1 (NK2 Homeobox 1) • SDC1 (Syndecan 1) • VIM (Vimentin) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • TP63 (Tumor protein 63) • CD99 (CD99 Molecule) • KRT20 (Keratin 20) • KRT5 (Keratin 5) • SYP (Synaptophysin)
    |
    TP53 wild-type • TP53 expression
    1year
    Customized 3D Printed Oral Stents During Head and Neck Radiotherapy (clinicaltrials.gov)
    P2, N=119, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Nov 2024 --> Dec 2026 | Trial primary completion date: Nov 2024 --> Dec 2026
    Trial completion date • Trial primary completion date
    over1year
    3-Fr steerable microcatheter system via the upper limb artery in RADPLAT for right maxillary cancer. (PubMed, Minim Invasive Ther Allied Technol)
    To evaluate the efficacy of a catheter system using a 3-Fr sheath with a steerable microcatheter through right upper limb artery access for superselective intra-arterial cisplatin infusion and concomitant radiotherapy (RADPLAT) to treat right maxillary sinus squamous cell carcinoma (MS-SCC)...No other major complications were observed during the procedure. Using a 3-Fr catheter system with a steerable microcatheter through right upper limb artery access is a feasible method for RADPLAT in treating right MS-SCC.
    Journal
    |
    PLAAT3 (Phospholipase A And Acyltransferase 3)
    |
    cisplatin
    over1year
    Post-treatment magnetic resonance imaging predicts outcomes of maxillary sinus cancer treatment using super-selective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT). (PubMed, Auris Nasus Larynx)
    The tumor reduction rate calculated from MRI T2-weighted images may be a predictor of local recurrence in patients with maxillary sinus cancer treated with RADPLAT. Patients with lower reduction rates may benefit from early salvage surgeries.
    Journal • MRI
    |
    PLAAT3 (Phospholipase A And Acyltransferase 3)
    |
    cisplatin
    2years
    Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment (clinicaltrials.gov)
    P=N/A, N=12, Completed, Thomas Jefferson University | Recruiting --> Completed | N=20 --> 12 | Trial completion date: Mar 2023 --> Jun 2023 | Trial primary completion date: Mar 2022 --> Jun 2023
    Trial completion • Enrollment change • Trial completion date • Trial primary completion date
    2years
    Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (JCOG1212): Results of the efficacy confirmation phase in patients with T4aN0M0: RADPLAT for T4aN0M0 Maxillary Sinus Cancer. (PubMed, Int J Radiat Oncol Biol Phys)
    We demonstrated that RADPLAT showed favorable results for patients with T4aN0M0 MS-SCCs compared with the historical control for 3yr OS in surgery, which was from an earlier period, and showed some specific toxicities. Therefore, RADPLAT, as well as surgery, can be regarded as a possible treatment option for these patients.
    Journal • Metastases
    |
    PLAAT3 (Phospholipase A And Acyltransferase 3)
    |
    cisplatin
    over2years
    A Rare Case of Tubercular Osteomyelitis of Maxilla: A Case Report. (PubMed, Indian J Otolaryngol Head Neck Surg)
    She underwent endoscopic debridement of sinuses and histopathological examination was suggestive of Koch's infection. Patient was further treated with antitubercular therapy and showed significant improvement at four weeks follow up.
    Journal
    over2years
    Surgical approach analysis of endoscopic resection of juvenile nasopharyngeal angiofibroma (PubMed, Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi)
    Endoscopic resection of nasopharyngeal fibroangioma is the main treatment method for JNA. Selecting suitable endoscopic approach to resect JNA, To maximize the advantage of nasal endoscopic equipment according to the inherent anatomical space of the human nasal cavity, In order to achieve the purpose of JNA resection, reduce intraoperative and postoperative complications, reduce the recurrence rate and improve the prognosis.
    Journal