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    GENE:

    MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4)

    i
    Other names: MAST4, Microtubule Associated Serine/Threonine Kinase Family Member 4, KIAA0303, Microtubule-Associated Serine/Threonine-Protein Kinase 4
    6ms
    Interpretable Machine Learning for Proteomics-Based Subtyping and Tumor Mutational Burden Prediction in Endometrial Cancer. (PubMed, Proteomics Clin Appl)
    Our proteomics-driven ML approach demonstrates high accuracy and interpretability in EC subtype classification and TMB prediction. By identifying validated and novel biomarkers, this strategy provides essential biological insights and a strong foundation for the future development of non-invasive diagnostics, personalized treatments, and precision medicine in EC.
    Journal • Tumor mutational burden • MSi-H Biomarker
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • MLH1 (MutL homolog 1) • PMS2 (PMS1 protein homolog 2) • RPL22L1 (Ribosomal Protein L22 Like 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • MTHFD2 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2)
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    MSI-H/dMMR • TMB-L
    11ms
    Integrating single-cell sequencing and clinical insights to explore malignant transformation in odontogenic keratocyst. (PubMed, Comput Struct Biotechnol J)
    In conclusion, COKC exhibits distinct molecular, cellular, and clinical characteristics compared to OKC, featuring potent neuroinvasiveness and low lymph node metastatic potential. These findings provide important insights into the mechanisms underlying COKC development and may guide novel diagnostic and therapeutic strategies.
    Journal
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    VEGFC (Vascular Endothelial Growth Factor C) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • EXT1 (Exostosin Glycosyltransferase 1)
    almost2years
    Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma. (PubMed, Int J Mol Sci)
    We established MIA-GEM cells, a PDAC cell line resistant to gemcitabine (GEM), a first-line anticancer drug, using the human PDAC cell line-MIA-PaCa-2...Elevated MAST4 expression correlated with a poorer prognosis in PDAC. Consequently, nuclear MAST4 emerges as a potential marker for GEM resistance and poor prognosis, representing a novel therapeutic target for PDAC.
    Journal
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    AKT3 (V-akt murine thymoma viral oncogene homolog 3) • FOXO3 (Forkhead box O3) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4)
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    AKT3 overexpression
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    gemcitabine
    almost2years
    Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes. (PubMed, Blood Adv)
    By investigating the Genomics of Drug Sensitivity in Cancer (GDSC) database, we identified axitinib and taselisib as candidate compounds that could potentially target the KISS-high myeloblasts. Altogether, our findings suggest that KISS holds the potential to improve the current prognostic scheme of MDS and inform novel therapeutic opportunities.
    Journal
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    TP53 (Tumor protein P53) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NPM1 (Nucleophosmin 1) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • STAG2 (Stromal Antigen 2) • PTK7 (Protein Tyrosine Kinase 7) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • PAK6 (P21 (RAC1) Activated Kinase 6)
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    TP53 mutation • STAG2 mutation
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    axitinib • taselisib (GDC-0032)
    over2years
    Integration of clinical characteristics and molecular signatures of the tumor microenvironment to predict the prognosis of neuroblastoma. (PubMed, J Mol Med (Berl))
    The prognosis of samples in the poor prognosis group (PP) was significantly worse than that of samples in the good prognosis group (GP). Finally, through scRNA-seq data, we found that as an important prognostic marker, USP39 might participate in the regulation of RNA splicing in NB.
    Journal
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    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • IL1RAP (Interleukin 1 Receptor Accessory Protein) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • RPL8 (Ribosomal Protein L8)
    over2years
    A Network of 17 Microtubule-Related Genes Highlights Functional Deregulations in Breast Cancer. (PubMed, Cancers (Basel))
    A Systems Biology approach highlighted three major functional networks connecting the 17 MT-Rel genes and their partners, which are centered on spindle assembly, chromosome segregation and cytokinesis. Our studies identified mitotic Aurora kinases and their substrates as major targets for therapeutic approaches against breast cancer.
    Journal
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    AURKB (Aurora Kinase B) • KIF11 (Kinesin Family Member 11) • KIFC1 (Kinesin Family Member C1) • MAPT (Microtubule Associated Protein Tau) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • KIF20A (Kinesin Family Member 20A) • KIF2C (Kinesin Family Member 2C) • KIF4A (Kinesin Family Member 4A) • MTUS1 (Microtubule Associated Scaffold Protein 1) • RACGAP1 (Rac GTPase activating protein 1) • STMN1 (Stathmin 1) • GTSE1 (G2 And S-Phase Expressed 1) • KIF15 (Kinesin Family Member 15)
    over3years
    Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. (PubMed, Nucleic Acids Res)
    For example, we identified a novel breast cancer risk gene, MAST4, with expression that was repressed by glucocorticoids in cells carrying the risk genotype, repression that correlated with MAST4 expression in breast cancer and treatment outcomes. These observations provide a mechanistic framework for understanding non-coding genetic variant-chemical environment interactions and their role in disease risk and drug response.
    Journal
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    MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4)
    over3years
    Systematic scoping review evaluating the potential of wastewater-based epidemiology for monitoring cardiovascular disease and cancer. (PubMed, Sci Total Environ)
    Finally, estimating prevalence-adjusted wastewater measurements was explored in order to assess community-level CVD and cancer presence utilizing U.S. reported prevalence rates. Results obtained suggest that WBE can serve as a viable tool in support of current methods for CVD and cancer assessment to reduce morbidities and mortalities worldwide.
    Review • Journal
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    AFP (Alpha-fetoprotein) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4)