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    GENE:

    MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3)

    i
    Other names: MAPK8IP3, Mitogen-Activated Protein Kinase 8 Interacting Protein 3, JIP3, KIAA1066, JSAP1, Syd, C-Jun-Amino-Terminal Kinase-Interacting Protein 3, Homolog Of Drosophila Sunday Driver 2, JNK MAP Kinase Scaffold Protein 3, JNK-Interacting Protein 3, JIP-3, JNK/Stress-Activated Protein Kinase-Associated Protein 1, Mitogen-Activated Protein Kinase 8-Interacting Protein 3, C-Jun-Amino-Terminal Kinase Interacting Protein 3, JNK/SAPK-Associated Protein-1, NEDBA, SYD2
    Associations

    News

    Trials
    5ms
    Differential expression analysis of lncRNA and mRNA in ovarian tissues of Pishan Red Sheep and Hu Sheep with distinct genotypes during estrus. (PubMed, Front Vet Sci)
    The specifically highly expressed MSTRG.2677.1 in Hu Sheep may be involved in maintaining ovarian stromal cell homeostasis through trans-regulation of HGF and BRINP3, MSTRG.27015.1 and MSTRG.60286.1 target MAPK8IP3 and PPP3CB respectively, suggesting their potential roles in cell cycle regulation and oocyte maturation. These findings provide important molecular mechanisms and potential regulatory targets for improving reproductive performance in sheep.
    Journal
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    ERBB4 (erb-b2 receptor tyrosine kinase 4) • MMP9 (Matrix metallopeptidase 9) • BRINP3 (BMP/Retinoic Acid Inducible Neural Specific 3) • MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3)
    over2years
    RNA-Sequencing Analysis Indicates That N-Cadherin Promotes Prostate Cancer Progression by the Epigenetic Modification of Key Genes. (PubMed, DNA Cell Biol)
    In summary, we identified several oncogenes and biological functions associated with N-cadherin expression in PCa cells. N-cadherin may trigger epigenetic reprogramming in PCa cells to promote tumor progression.
    Journal
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    POLD1 (DNA Polymerase Delta 1) • CDH2 (Cadherin 2) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit) • GTF2H4 (General Transcription Factor IIH Subunit 4) • MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3)
    over2years
    The genomic landscape associated with resistance to aromatase inhibitors in breast cancer. (PubMed, Genomics Inform)
    This study aims at identifying the plausible cause of acquired AI resistance in patients administered with non-steroidal AIs (anastrozole and letrozole). Pathway analysis revealed HSD3B1 to be involved in estrogen biosynthesis. This study reveals the involvement of key genes that might be associated with the development of AI resistance in ER-positive breast cancers and hence may act as a potential prognostic and diagnostic biomarker for these patients.
    Journal
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    ER (Estrogen receptor) • FGFR3 (Fibroblast growth factor receptor 3) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • HSD3B1 (Hydroxy-Delta-5-Steroid Dehydrogenase 3 Beta- And Steroid Delta-Isomerase 1) • MAPK4 (Mitogen-Activated Protein Kinase 4) • MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3)
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    TP53 mutation • ER positive • FGFR3 mutation • CDKN2A mutation
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    letrozole • anastrozole