MAPK3 (Mitogen-Activated Protein Kinase 3)

These findings suggest that CacyBP/SIP may play a critical role in urothelial carcinoma progression by modulating ERK1/2 and p38 kinase activity.

We identified circulating ERP29, MCL1, TNXB, DAGLB, FES, TRPM4, MAPK3, and TNF as promising, genetically supported druggable targets for CAD treatment. Notably, MAPK3 and TNF demonstrated strong protein-level interactions and close associations with cardiometabolic disorders.

It can be concluded that, down-regulation of MAPK3 and KIT and up-regulation of BMP4 which are the consequence of microsecond PEF treatment inhibit medulloblastoma. The results exhibited the significant role of MAPK3 in response to microsecond PEF treatment.

These findings suggest that the oxidative phosphorylation pathway plays a pivotal role in the secretory functions of pituitary adenomas. This study offers new insights into the biological mechanisms underlying pituitary adenomas and provides valuable directions for future research, emphasizing the importance of oxidative phosphorylation in tumor behavior and potential therapeutic targets.

Although MAPK alterations are pervasive in CRC, their distribution varies meaningfully by ancestry, age, and treatment exposure. These findings highlight NF1, MAPK3, RPS6KA4, and PDGFRB as potential biomarkers in EOCRC and H/L patients, supporting the need for ancestry-aware precision oncology approaches.

RTK-RAS pathway alterations demonstrate strong age-, ancestry-, and treatment-specific prognostic effects and may serve as precision biomarkers of differential chemotherapy response. AI-enabled analytics substantially accelerated integrative biomarker discovery, supporting their utility for advancing precision oncology in EOCRC.

Cell experiments showed that sodium hydrosulfide (NaHS), a donor of H2S, prominently inhibited cell proliferation, promoted cell apoptosis for CRC, and downregulated the expression of MAPK1, MAPK3, AKT1, and JUN. Taken together, this study elucidates the possible genes and therapeutic mechanisms underlying exogenous H2S intervention in CRC, thereby laying a foundation for the further development of H2S-based therapeutic strategies in CRC management.

Energy decomposition analysis suggested that complex stabilization is primarily driven by shape complementarity and hydrophobic effects, rather than conventional hydrogen bonding or salt bridges. Conclusion This study reveals that the antitumor activity of Baicalein is mediated through its multi-target action on core components of the PI3K-AKT pathway, thereby offering novel insights for exploring its therapeutic targets.

Hsp90α knockdown simultaneously destabilizes EGFR and its downstream AKT/mTOR and ERK axes,resulting in multi-modal suppression of Lactotroph PitNETs invasion.Targeting Hsp90α may offer a novel therapeutic strategy for Aggressive Lactotroph PitNETs refractory to standard medical therapy.

Forty-eight male Sprague Dawley(SD) rats were randomly divided into a sham group, a model group, high-dose, medium-dose, and low-dose groups of Spatholobi Caulis, and a positive control group of Pregabalin, with eight rats in each group...The molecular docking results showed that multiple components had a good affinity for TLR4 and MyD88, and buddleoside had the highest affinity for TLR4 and MyD88. In summary, Spatholobi Caulis can inhibit microglia activation and alleviate NP by modulating the TLR4/MyD88/NF-κB signaling pathway.

Rats were administered OANG (high/low dose) intra-articularly, with celecoxib as a positive control...Furthermore, OANG ameliorated hippocampal oxidative stress and inflammation (decreased Cleaved caspase-3, Malondialdehyde; increased IL-10). Network pharmacology and docking suggested the involvement of peroxisome proliferator-activated receptor gamma, mitogen-activated protein kinase 3, prostaglandin-endoperoxide synthase 2, and pathways such as estrogen signaling and cyclic adenosine monophosphate signaling.

Animal experiments verified that the JPXK recipe had a good hypoglycemic effect. This study revealed the active ingredients and potential molecular mechanism of the JPXK recipe in the treatment of T2DM, which provides valuable experience in future clinical trials.