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    BIOMARKER:

    MAPK1 R135K

    i
    Other names: MAPK1, ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2, Mitogen-activated protein kinase 1
    Entrez ID:
    5594
    Related biomarkers:
    Expression
    Mutation
    5years
    Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma. (PubMed, NPJ Genom Med)
    Residues D321, R135, and E322 are in 3D proximity. MAPK1p.D321N drives marked in vivo erlotinib sensitivity, while p.R135K's effect is moderate.
    Journal
    |
    MAPK1 (Mitogen-activated protein kinase 1)
    |
    MAPK1 R135K
    |
    erlotinib