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    BIOMARKER:

    MAPK1 D321N

    i
    Other names: MAPK1, ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2, Mitogen-activated protein kinase 1
    Entrez ID:
    5594
    Related biomarkers:
    Expression
    Mutation
    almost3years
    ERK2 Mutations Affect Interactions, Localization, and Dimerization. (PubMed, Biochemistry)
    The crystal structure of ERK2 E322K also indicated a disturbed dimer interface, and reduced dimerization was detected by a two-hybrid test; yet, it was detected in dimers in EGF-treated cells, although to a lesser extent than D321N or wt ERK2. These findings indicate a range of small differences in behaviors that may contribute to increased function of E322K in certain cancers.
    Journal
    |
    MAP2K1 (Mitogen-activated protein kinase kinase 1) • MAP2K2 (Mitogen-activated protein kinase kinase 2) • MAPK1 (Mitogen-activated protein kinase 1) • EGF (Epidermal growth factor)
    |
    MAPK1 D321N • MAPK1 E322K