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    DRUG CLASS:

    MAP4K2 inhibitor

    Related drugs:
    1year
    MAP4K2 connects the Hippo pathway to autophagy in response to energy stress. (PubMed, Autophagy)
    Moreover, MAP4K2 is highly expressed in head and neck cancer, while MAP4K2 and its mediated autophagy are required for head and neck cancer development. Taken together, our study not only reveals a noncanonical role of the Hippo pathway in energy stress response, but also suggests Hippo kinase MAP4K2 as a potential therapeutic target for head and neck cancer treatment.
    Journal
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    YAP1 (Yes associated protein 1) • MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha)
    over1year
    A non-canonical role: The Hippo pathway regulator MAP4K2 controls autophagy and cell survival upon energy stress. (PubMed, Mol Cell)
    In this issue, Seo et al. report a non-canonical function of the Hippo kinase MAP4K2 in energy stress response by regulating autophagy and cell survival, with relevance and therapeutic potential for head and neck cancer treatment.
    Journal
    almost2years
    CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma. (PubMed, Histol Histopathol)
    In conclusion, circ_PDE3B acted as oncogenic circRNA in ESCC and accelerated ESCC progression by adsorption of miR-136-5p and activation of MAP3K2, supporting circ_PDE3B as a potential therapeutic target for ESCC.
    Journal
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    MIR136 (MicroRNA 136)
    over2years
    CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis. (PubMed, Histol Histopathol)
    CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis.
    Journal
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    MIR200A (MicroRNA 200a) • BACH1 (BTB Domain And CNC Homolog 1)
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    miR-200-a expression
    almost3years
    Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach. (PubMed, Comput Math Methods Med)
    Moreover, DEFB1 was found to be involved in the tumor immunity of OSCC by regulating the function of tumor macrophage cells, mast cells, T cells, and NK cells. Given the dysregulation, prognostic value, and tumor progression-related biological pathway alteration, indicating the tumor immune-modulatory role of DEFB1 in OSCC, the DEFB1 gene should be regarded as a potential therapeutic target for treating oral cancer.
    Journal
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    CCR6 (C-C Motif Chemokine Receptor 6) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • MMP7 (Matrix metallopeptidase 7)
    over3years
    Machine Learning for Building Immune Genetic Model in Hepatocellular Carcinoma Patients. (PubMed, J Oncol)
    The immune-risk model, based on expression of SPP1, BRD8, NDRG1, KITLG, HSPA4, TRAF3, ITGAV, and MAP4K2, can better differentiate patients into high and low immune-risk groups. Combined nomogram, using immune-risk score and tumor stages, could make accurate prediction of 1-, 3- and 5-year survival in HCC patients.
    Clinical • Journal
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    SPP1 (Secreted Phosphoprotein 1) • NDRG1 (N-Myc Downstream Regulated 1)
    almost4years
    microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit. (PubMed, Oncogene)
    Besides, downregulation of miR-93-5p significantly retarded tumor growth, while overexpression of miR-93-5p accelerated tumor growth in the HCC xenograft mouse model. Altogether, we revealed a miR-93-5p/MAP3K2/c-Jun positive feedback loop to promote HCC progression in vivo and in vitro, representing an RNA-activating role of miR-93-5p in HCC development.
    Journal
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    MIR93 (MicroRNA 93)