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    GENE:

    MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10)

    i
    Other names: MAP3K10, Mitogen-Activated Protein Kinase Kinase Kinase 10, Mixed Lineage Kinase 2, MST, MKN28 Derived Nonreceptor_type Serine/Threonine Kinase, Protein Kinase MST, MKN28 Kinase, MEKK10, MLK2
    10ms
    Mixed lineage kinase (MLK) controls tumor development and angiogenesis. (PubMed, Angiogenesis)
    Additionally, the MLK family of kinases acts through the long noncoding RNA (lncRNA) H19 to control the expression of these pro-angiogenic factors in the endothelium. Collectively, these findings suggest that the MLK-H19 axis coordinates endothelial function, angiogenesis, and tumor growth.
    Journal
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    MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) • MMP9 (Matrix metallopeptidase 9) • ADAM8 (ADAM Metallopeptidase Domain 8) • MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11)
    1year
    Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance. (PubMed, Hereditas)
    This comprehensive assessment provides valuable insights into the role of MAP3K genes in GC, offering avenues for further research and therapeutic exploration.
    Journal
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    MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) • MIR200B (MicroRNA 200b) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) • MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) • MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8) • MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) • MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7) • MAP3K5 (Mitogen-Activated Protein Kinase Kinase Kinase 5)
    over1year
    Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients. (PubMed, Klin Onkol)
    In the pilot study, we found promising copy number variation biomarkers of bevacizumab response in FFPE samples of mCRC patients. The validation phase should be focused especially on the genes associated with angiogenesis (AGRN, MAPK8, ARHGAP22, LGALS13, LGALS4, ZFP36, and MYC), tumorigenesis (DVL1), and tumor proliferation (IFNL1, IFNL2, IFNL3, MAP3K10, and MAP4K1).
    Journal • Metastases
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    LGALS1 (Galectin 1) • MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) • LGALS4 (Galectin 4) • AGRN (Agrin) • DVL1 (Dishevelled Segment Polarity Protein 1) • IFNL1 (Interferon Lambda 1) • IFNL2 (Interferon Lambda 2) • IFNL3 (Interferon Lambda 3) • MAPK8 (Mitogen-activated protein kinase 8) • ZFP36 (ZFP36 Ring Finger Protein)
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    Avastin (bevacizumab)
    almost2years
    Genetic Landscape and Its Prognostic Impact in Children With Langerhans Cell Histiocytosis. (PubMed, Arch Pathol Lab Med)
    According to multivariate analysis, risk organ involvement was the strongest independent adverse prognostic factor (hazard ratio, 8.854; P < .001); BRAF or MAP2K1 mutation was not an independent prognostic factor. Most pediatric patients with LCH carry somatic mutations involving the MAPK pathway, correlating with clinical characteristics and outcomes for first-line chemotherapy.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) • ARAF (A-Raf Proto-Oncogene)
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    BRAF V600E • KRAS mutation • BRAF V600 • BRAF fusion
    almost5years
    MiR-146b-3p regulates proliferation of pancreatic cancer cells with stem cell-like properties by targeting MAP3K10. (PubMed, J Cancer)
    MiR-146b-3p inhibits proliferation and induced apoptosis in P-CSCs high cells lines by targeting MAP3K10. Targeting P-CSCs specific genes may provide novel strategies for therapeutic purposes.
    Journal
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    CD44 (CD44 Molecule) • MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) • CD24 (CD24 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • GLI2 (GLI Family Zinc Finger 2) • MIR146B (MicroRNA 146b)