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BIOMARKER:

MAP2K1 F53Y

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Other names: MAP2K1, MAPKK1, MEK1, PRKMK1, Mitogen-activated protein kinase kinase 1
Entrez ID:
Related biomarkers:
almost2years
Dynamic evolution of clonal composition and neoantigen landscape in recurrent metastatic melanoma with a rare combination of driver mutations. (PubMed, J Invest Dermatol)
The mutant proteins cooperatively activate the MAP kinase signalling pathway confirming they are potential driver mutations of this tumour. We hence describe the long-term genetic evolution of cutaneous metastatic melanoma characterised by an unexpected phenotypic stability and neoantigen driven clonal selection.
Journal
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BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog) • MAP2K1 (Mitogen-activated protein kinase kinase 1)
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BRAF mutation • BRAF fusion • MAP2K1 F53Y