MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha)

Furthermore, Morin significantly decreased mitochondrial membrane potential (**P < 0.001-***P < 0.0001, #P < 0.01). Morin, reduced MCF-7 cell survival and proliferation, enhanced apoptosis, increased ROS production, and diminished mitochondrial membrane potential, confirming its potential anticancer role.

The effect of RT (8 and 3 × 8 Gy) on Interferon beta (IFNβ), IFN-stimulated genes (ISGs), and HLA-class-I expression in combination with IFN-type-I-response inhibitors (Ruxolitinib, Tofacitinib, Amlexanox) targeting the JAK and TBK1 was studied with Flow cytometry and RT-PCR. The current study supports the theory that baseline autophagy, RT-induced autophagy blockage, and IFN-type-I response enhancement define the HLA-class-I levels in NSCLC cells. This complex interplay emerges as a promising target for the development of radio-vaccination strategies to enhance the efficacy of radio-immunotherapy.

This study assesses the chemosensitizing ability of Black Grape Anthocyanins (BGA) derived from the Manjari Medika (MM) grape variety to improve the efficacy of low-dose 5-Fluorouracil (5-FU) in HepG2 cells...Importantly, BGA showed little cytotoxicity in primary hepatocytes. Overall, BGA works as a strong, selective chemosensitiser that improves 5-FU efficacy via ROS-mediated regulation of calcium signalling, apoptosis, and autophagy in HCC cells.

Morin induces mitophagy, promotes apoptosis, and suppresses cancer invasiveness in PC cells, highlighting its potential as an adjuvant therapeutic agent. Future clinical studies are warranted to evaluate its relevance.

However, there was a parallel drop in p62 expression, which indicates autophagy induction. AICAR increased the influence of WJ-CM on viability, as well as the levels of biomarkers associated with autophagy, phosphorylated  AMPK, and phosphorylated  mTOR in the HT-29 cells. WJ-CM inhibits colorectal cancer cell growth via activating AMPK/mTOR-mediated autophagy.

Co-treatment with OCT mitigated these effects by improving sperm parameters, hormone levels, oxidative stress markers, inflammatory cytokines, and testicular histology.DiscussionThe findings suggest that OCT exerts a protective effect against BPA-induced testicular toxicity, through its anti-inflammatory, antioxidant, and autophagy-modulating properties. OCT may offer therapeutic potential in mitigating BPA-induced testicular toxicity.

We have done a retrospective archived tissue study on cervical cancer biopsy specimens to study the immunoexpression of autophagy markers LC3A and LC3B and their correlation with clinicopathological parameters. Targeted manipulation of autophagy will provide therapeutic avenues for designing optimal therapeutic strategies in cancer therapy.

BRD4 inhibition promotes autophagy of ESCC cells via a histone acetylation-dependent mechanism, thereby enhancing EMT and ultimately increasing cell migration driven by ACC1 deficiency.

SIGNIFICANCE STATEMENT: This study demonstrates the selective anticancer activity of JAMC-4/108, a Mongolian herbal extract, against colorectal cancer cells, with distinct apoptotic mechanisms and minimal toxicity to normal cells. These findings support the potential of JAMC-4/108 as a novel therapeutic candidate for colorectal cancer treatment, highlighting its pharmacological efficacy and safety profile for further development.

Andro's effects were attenuated by autophagy inhibitor chloroquine, indicating its pharmacological action via autophagy inhibition in chondrosarcoma cells. Therefore, Andro could reduce the migration and invasion of chondrosarcoma cells by modulating the PI3K/Akt/mTOR signaling pathway, alleviating autophagy inhibition, and subsequently promoting autophagic activity.

Notably, CRV administration preserved spatial learning and memory function in CP-treated rats, as demonstrated by the Morris Water Maze test, indicating functional neuroprotection. These findings highlight the multifaceted neuroprotective mechanisms of CRV and suggest its potential as a food-derived bioactive compound for development into functional foods or dietary supplements to improve the quality of life for cancer patients undergoing chemotherapy.

Treatment with Mdivi-1 ameliorated these effects, reducing neurotoxicity in zebrafish. This study elucidates the synergistic neurodevelopmental toxicity of ACE and IMI, underscores the pivotal role of mitochondrial pathways, and provides insights into potential mitigation strategies for neonicotinoid-induced neurotoxicity.