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BIOMARKER:

MALT1 expression

i
Other names: MALT1, MALT1 Paracaspase, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1, Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1, MALT1 Protease, PCASP1, MLT, MALT Lymphoma-Associated Translocation, Caspase-Like Protein, Paracaspase 1, Paracaspase-1, Paracaspase, IMD12, MLT1
Entrez ID:
Related biomarkers:
2ms
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability. (PubMed, Proc Natl Acad Sci U S A)
Moreover, we show that targeting MALT1 synergizes with sorafenib or regorafenib to induce ferroptosis across multiple cancer types. These findings elucidate the modulatory effects of the MALT1-RC3H1 axis on GPX4 stability, revealing a molecular mechanism that could be exploited to induce ferroptosis for cancer therapy.
Journal
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GPX4 (Glutathione Peroxidase 4) • MALT1 (MALT1 Paracaspase)
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MALT1 expression
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sorafenib • Stivarga (regorafenib)
2ms
MALT1 promotes the antibacterial immune response by activating NF-κB signaling and enhancing hemocyte phagocytosis in the Chinese mitten crab. (PubMed, Fish Shellfish Immunol)
In vivo, silencing of EsMALT1 rendered crabs susceptible to bacterial infection and impaired their bacterial clearance. In conclusion, EsMALT1 promotes both humoral and cellular immunity in E. sinensis, making it essential for the induction of antibacterial immune responses.
Journal • IO biomarker
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
4ms
Glucose Upregulates ChREBP via Phosphorylation of AKT and AMPK to Modulate MALT1 and WISP1 Expression. (PubMed, J Cell Physiol)
Our findings illustrated that ChREBP is an oncogene in the human prostate. High glucose condition induces a glucose/ChREBP/MALT1/NF-κB axis which links the glucose metabolism to the NF-κB activation in prostate cancer cells, and a glucose/ChREBP/WISP1 axis mediating autocrine and paracrine signaling between fibroblasts and cancer cells to promote cell migration, contraction, growth, and invasion of the human prostate.
Journal
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FN1 (Fibronectin 1) • MALT1 (MALT1 Paracaspase) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
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MALT1 expression
11ms
Blood MALT1 expression could help predict treatment outcomes in psoriasis patients, especially in those receiving biologics. (PubMed, Immun Inflamm Dis)
Blood MALT1 measurement may assist in predicting outcomes in psoriasis patients, especially in those receiving biologics.
Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
12ms
Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis. (PubMed, Cell Commun Signal)
Overall, our data reveal a previously unrecognized role of the MALT1-LPCAT3 axis in osteoarthritis. Targeting the MALT1-LPCAT3 pathway with MALT1 inhibitors or siRNA-liposomes of LPCAT3 may become an effective strategy to treat OA by suppressing eicosanoids, matrix-degrading enzymes, and proinflammatory cytokines.
Journal
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MALT1 (MALT1 Paracaspase) • IL1B (Interleukin 1, beta) • LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) • MMP3 (Matrix metallopeptidase 3)
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MYC expression • MALT1 expression • MALT1 overexpression
1year
MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus. (PubMed, Inflammation)
The effects of MALT1 and mechanistic target of rapamycin (mTOR) on T-cell immunity were investigated through western blot, CCK8 assay, and flow cytometry...MALT1 expression is aberrant in both local lesions and peripheral blood of OLP. Inhibition of the mTOR pathway further enhances the suppression of T-cell proliferation and the promotion of apoptosis induced by the MALT1 inhibitor MI-2.
Journal
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MALT1 (MALT1 Paracaspase) • IL15 (Interleukin 15) • IL7 (Interleukin 7)
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MALT1 expression
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sirolimus
1year
Identification of an Ortholog of MALT1 from Shrimp That Induces NF-κB-Mediated Antiviral Immunity. (PubMed, Viruses)
Furthermore, LvMALT1 is prominently upregulated in response to a challenge by the white spot syndrome virus (WSSV), facilitating the NF-κB-mediated expression of AMPs as a defense against viral infection. Taken together, we identified a MALT1 homolog from the shrimp L. vannamei, which plays a positive role in the TRAF6/NF-κB/AMPs axis-mediated innate immunity.
Journal
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MALT1 (MALT1 Paracaspase) • TRAF6 (TNF Receptor Associated Factor 6)
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MALT1 expression • MALT1 overexpression
1year
Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination. (PubMed, Proc Natl Acad Sci U S A)
Moreover, silencing of Tensin-3 expression in MALT1-driven lymphoma promoted dissemination of xenografted lymphoma cells to the bone marrow and spleen. Thus, MALT1-dependent Tensin-3 cleavage reveals a unique aspect of the function of MALT1, which negatively regulates integrin-dependent B cell adhesion and facilitates metastatic spread of B cell lymphomas.
Journal
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MALT1 (MALT1 Paracaspase) • TNS3 (Tensin 3)
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MALT1 expression
over1year
Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer. (PubMed, Oncol Lett)
Decreased MALT1 expression after treatment and a decline in MALT1 expression of >30% after treatment (ratio to MALT1 before treatment) (both P≤0.001) presented more significant associations with prolonged PFS and OS times. In conclusion, early low levels of blood MALT1 during therapy may predict an improved response to PD-1 inhibitor-based treatment and survival time in patients with mCRC.
Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
almost2years
MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. (PubMed, Life Sci)
Finally, we show that MALT1 expression is positively correlated with NF-kB activation in human HCC tissues and cell lines, suggesting that its tumor promoting functions may involve functional interaction with the NF-kB signaling pathway. This work unveils new insights into the molecular implications of MALT1 in hepatocarcinogenesis and places this paracaspase as a potential marker and druggable liability in HCC.
Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
almost2years
Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and -Independent Pathways in Prostate Carcinoma Cells. (PubMed, Int J Mol Sci)
Ectopic ARv7 overexpression not only enhanced 22Rv1 or PC-3 cell growth and invasion in vitro but also the tumor growth of PC-3 cells in vivo. These results indicate that an androgen receptor induces MALT1 expression androgen-dependently and -independently in ARFL- or ARv7-overexpressed prostate cancer cells, suggesting a novel ARv7/MALT1/NF-κB-signaling pathway may exist in the cells of prostate cancer.
Journal
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AR (Androgen receptor) • MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • MALT1 (MALT1 Paracaspase) • NDRG1 (N-Myc Downstream Regulated 1)
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AR expression • AR splice variant 7 • AR-V7 expression • AR-V7 overexpression • MALT1 expression
almost2years
Targeting of MALT1 May Improve Functional Recovery and Attenuate Microglia M1 Polarization-Mediated Neuroinflammation During Spinal Cord Injury. (PubMed, Mol Neurobiol)
Furthermore, MALT1 knockdown suppressed NF-κB pathway activation validated by immunofluorescence staining and western blot assays (all P < 0.05). MALT1 knockdown improves functional recovery, attenuates microglia activation, M1 polarization, and neuroinflammation via inhibiting NF-κB pathway in SCI.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • MALT1 (MALT1 Paracaspase) • IL1B (Interleukin 1, beta) • MRC1 (Mannose Receptor C-Type 1) • CD86 (CD86 Molecule)
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IL6 expression • MALT1 expression • MALT1 overexpression
2years
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination. (PubMed, Mol Neurobiol)
Blockage of MALT1 with its inhibitor or siRNA reduced STEP61 degradation, accompanied by a decrease in GluN2B phosphorylation, intracellular calcium concentration, and brain cell injury, which were reversed by overexpression of MALT1. Based on these observations, we conclude that the downregulation of HECTD4 in ischemic stroke rat brain accounts for calcium overload and brain injury due to activating GluN2B directly and indirectly through a mechanism involving the reduced ubiquitination of GluN2B and MALT1, respectively.
Journal
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MALT1 (MALT1 Paracaspase) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)
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MALT1 expression
over2years
Blood MALT1 deficiency is common and relates to unfavorable induction therapy response and survival profile in acute myeloid leukemia patients. (PubMed, Hematology)
Furthermore, MALT1 increment during induction treatment < 50% was related to unsatisfied accumulating EFS (P = .001) and OS (P = .007). PBMC MALT1 deficiency is common and relates to unfavorable induction therapy response and survival profile in AML patients.
Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
over2years
MALT1 serves as a biomarker for estimating disease risk of lupus nephritis: a prospective case-control study. (PubMed, Ann Transl Med)
MALT1 was positively linked to 24 h proteinuria (r=0.473, P=0.008), Scr (r=0.378, P=0.039), and C-reactive protein (CRP) (r=0.410, P=0.025) in LN patients. MALT1 might serve as a useful biomarker for estimating the disease risk in LN patients; however, future large-sample size studies need to be conducted to validate our findings.
Journal
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MALT1 (MALT1 Paracaspase) • CRP (C-reactive protein)
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MALT1 expression
over2years
HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway. (PubMed, Arch Physiol Biochem)
Over-expression of MALT1 attenuated neuroprotective effects of HECTD3 silencing on high glucose-induced PC12 cells. HECTD3 silencing exerted neuroprotective effect against DACD through MALT1-mediated JNK signalling.HighlightsHECTD3 was up-regulated in hippocampus of streptozotocin-induced diabetic rats and high glucose-induced PC12.Knockout of HECTD3 promoted in vivo neuronal survival, reduced inflammation and pyroptosis, and improved the learning and memory function in diabetic rats.Knockout of HECTD3 suppressed the activation of NLRP3 inflammasome in diabetic rats.Silencing of HECTD3 exerted neuroprotective effects through MALT1-mediated JNK signalling.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MALT1 (MALT1 Paracaspase) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)
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MALT1 expression
over2years
MALT1 positively relates to Th17 cells, inflammation/activity degree, and its decrement along with treatment reflects TNF inhibitor response in ankylosing spondylitis patients. (PubMed, J Clin Lab Anal)
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 positively correlates with Th17 cells, inflammatory, and activity degree; meanwhile, its decrement along with treatment reflects the response to TNF inhibitor in AS patients.
Journal
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IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • MALT1 (MALT1 Paracaspase) • IL17A (Interleukin 17A)
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MALT1 expression
almost3years
MALT1 in asthma children: A potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance-mediated inflammation. (PubMed, J Clin Lab Anal)
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 serves as a potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance-mediated inflammation of asthma children.
Journal
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MALT1 (MALT1 Paracaspase) • IL4 (Interleukin 4)
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MALT1 expression
almost3years
Aberrant blood MALT1 and its relevance with multiple organic dysfunctions, T helper cells, inflammation, and mortality risk of sepsis patients. (PubMed, J Clin Lab Anal)
PBMC MALT1 is highly expressed in sepsis patients with its overexpression associated with multiple organic dysfunctions, elevated Th17 cells, and increased mortality risk.
Journal
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IFNG (Interferon, gamma) • MALT1 (MALT1 Paracaspase) • IL17A (Interleukin 17A) • CRP (C-reactive protein)
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MALT1 expression
almost3years
Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway. (PubMed, Food Funct)
Moreover, in rats with an E. coli-induced UTI model, allicin significantly alleviated the infection and up-regulation of MALT1 expression in the bladders, a marked increase in the bacterial load of urine, and deviations in serum biochemical parameters. In conclusion, allicin exerts anti-infective effects in UTIs mainly via the MALT1/NF-κB axis or AKT/NF-κB pathway, which provides a theoretical basis for understanding the function of allicin against UTIs and facilitates its clinical application.
Journal
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IL6 (Interleukin 6) • MALT1 (MALT1 Paracaspase) • IL1B (Interleukin 1, beta)
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MALT1 expression
almost3years
Potential role of MALT1 as a candidate biomarker of disease surveillance and treatment response prediction in inflammatory bowel disease patients. (PubMed, J Clin Lab Anal)
MALT1 serves as a potential biomarker for disease surveillance and treatment response prediction of IBD patients.
Clinical • Journal
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TNFA (Tumor Necrosis Factor-Alpha) • MALT1 (MALT1 Paracaspase) • IL17A (Interleukin 17A) • CRP (C-reactive protein)
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MALT1 expression
almost3years
Targeting MALT1 Suppresses the Malignant Progression of Colorectal Cancer via miR-375/miR-365a-3p/NF-κB Axis. (PubMed, Front Cell Dev Biol)
Mechanistically, miR-375 and miR-365a-3p were identified to inhibit NF-κB activation via targeting MALT1. Overall, our results highlight that a novel regulatory axis, miRNA-MALT1-NF-κB, plays a vital role in the progression of CRC and provides novel and hopeful therapeutic targets for clinical treatment.
Journal
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MALT1 (MALT1 Paracaspase) • MIR375 (MicroRNA 375)
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MALT1 expression
3years
Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway. (PubMed, Bioengineered)
Collectively, our study clarified the role of miR-3681-5p/MALT1 axis underlying the oncogenic function of lncRNA HOXD-AS2 in GBM. Future work is required to study the mechanism by which HOXD-AS2 is upregulated in GBM cells, which can provide novel insights into therapeutic intervention for GBM treatment.
Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
3years
The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-κB Signaling in Prostate Carcinoma Cells. (PubMed, Cancers (Basel))
CAPE induced the ERK/JNK/p38/AMPKα1/2 signaling pathways; however, pretreatment with the corresponding inhibitors of MAPK or AMPK1/2 did not inhibit the CAPE effect on MALT1 blocking in PC-3 cells. Our findings verify that CAPE is an effective antitumor agent for human androgen-dependent and -independent prostate carcinoma cells in vitro and in vivo through the inhibition of MALT1 expression via the AR/p53/NF-κB signaling pathways.
Journal
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AR (Androgen receptor) • MALT1 (MALT1 Paracaspase) • KLK3 (Kallikrein-related peptidase 3)
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AR positive • TP53 expression • MALT1 expression
3years
Integrative Analysis of MALT1 as a Potential Therapeutic Target for Prostate Cancer and its Immunological Role in Pan-Cancer. (PubMed, Front Mol Biosci)
Furthermore, MALT1 expression is closely related to the occurrence and development of multiple tumors in multiple ways. Therefore, MALT1 may be an emerging therapeutic target for a variety of cancers especially PCa.
Journal • Tumor Mutational Burden • Pan tumor
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TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • MALT1 (MALT1 Paracaspase) • TGFB1 (Transforming Growth Factor Beta 1)
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MALT1 expression
over3years
Blood MALT1, Th1, and Th17 cells are dysregulated, inter-correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome. (PubMed, J Clin Lab Anal)
MALT1, Th1, and Th17 cells are dysregulated, inter-correlated, and correlated with disease activity in RA patients; meanwhile, the decline of MALT1 expression can partly reflect RA treatment response and remission.
Clinical • Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression
over3years
MALT1 positively correlates with Th1 cells, Th17 cells, and their secreted cytokines and also relates to disease risk, severity, and prognosis of acute ischemic stroke. (PubMed, J Clin Lab Anal)
MALT1 expression is increased and positively correlates with disease severity, Th1 cells, and Th17 cells, whose high expression severs as an independent risk factor for worse RFS in AIS patients.
Journal
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IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • MALT1 (MALT1 Paracaspase) • IL17A (Interleukin 17A)
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MALT1 expression
almost4years
Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-κB Activity in Human Prostate Carcinoma Cells. (PubMed, Biomedicines)
MALT1 enhanced NF-κB activity in prostate carcinoma cells; moreover, NF-κB induced MALT1 expression determined by reporter and immunoblot assays, implying there is a positive feedback loop between MALT1 and NF-κB. In conclusion, MALT1 is a NF-κB-induced oncogene in the human prostate carcinoma cells.
Journal
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IL6 (Interleukin 6) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • MALT1 (MALT1 Paracaspase) • CXCL5 (Chemokine (C-X-C motif) ligand 5)
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MALT1 expression
almost4years
MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies. (PubMed, Med Res Rev)
Finally, we propose future research directions to accelerate the discovery of novel MALT1 inhibitors with clinical applications. Overall, this review provides a comprehensive and systematic overview of MALT1-related research advances and serves as a theoretical basis for drug discovery and research.
Review • Journal
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MALT1 (MALT1 Paracaspase)
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MALT1 expression