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    BIOMARKER:

    MALAT1 underexpression

    i
    Other names: MALAT1, Metastasis associated lung adenocarcinoma transcript 1, NEAT2, PRO2853, LINC00047, NCRNA00047
    Entrez ID:
    378938
    Related biomarkers:
    Expression
    1m
    Integrating Machine Learning-Predicted Circulating Tumor Cells (CTCs) and circulating tumor DNA (ctDNA) in Metastatic Breast Cancer: a proof of principle study on endocrine resistance profiling. (PubMed, Cancer Lett)
    The pilot exploratory CTCs transcriptomics analysis showed transcriptional changes linked to cell proliferation such as under expression of MALAT1 and overexpression of GREM1, GPR85 and OCM. Our data underline the potential of an integration between ctDNA and CTCs, both through quantification and transcriptomic analysis, for a deeper understanding of tumor biology and treatment response in HR-positive, HER2-negative MBC.
    Journal • Circulating tumor cells • Circulating tumor DNA • Machine learning • Tumor cell • Metastases
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    HER-2 (Human epidermal growth factor receptor 2) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • GREM1 (Gremlin 1)
    |
    HR positive • HER-2 negative • MALAT1 underexpression • PTEN mutation + HR positive