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    BIOMARKER:

    MAGEE1 expression

    i
    Other names: HCA1; DAMAGE
    Entrez ID:
    57692
    2years
    S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate. (PubMed, Metabolites)
    They also emphasize the differences in C6 glioma cells regarding energetic metabolism. The proposed mechanism via HCAR1 provides further compelling evidence of the relationship between S100B and glucose metabolism.
    Journal
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    MAGEE1 (MAGE family member E1) • HCAR1 (Hydroxycarboxylic Acid Receptor 1) • S100B (S100 Calcium Binding Protein B)
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    MAGEE1 expression
    over2years
    Curcumin derivative NL01 induces ferroptosis in ovarian cancer cells via HCAR1/MCT1 signaling. (PubMed, Cell Signal)
    NL01 exhibits better anti-tumor growth properties than curcumin, and NL01 induces ferroptosis in ovarian cancer cells.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • SLC16A1 (Solute Carrier Family 16 Member 1) • MAGEE1 (MAGE family member E1) • HCAR1 (Hydroxycarboxylic Acid Receptor 1)
    |
    GPX4 expression • MAGEE1 expression
    |
    cisplatin
    almost3years
    Whole grain metabolite 3,5-dihydroxybenzoic acid is a beneficial nutritional molecule with the feature of a double-edged sword in human health: a critical review and dietary considerations. (PubMed, Crit Rev Food Sci Nutr)
    Thus, there is an urgent need to fully identify the role of whole-grain-derived 3,5-DHBA during anticancer therapy and its contribution in the regulation of vital organs of the body via its specific HCAR1 receptor. We discuss here in detail the possible consequences of the modulatory capabilities of 3,5-DHBA in physiological and pathological conditions in humans.
    Review • Journal
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    MAGEE1 (MAGE family member E1) • HCAR1 (Hydroxycarboxylic Acid Receptor 1)
    |
    MAGEE1 expression
    3years
    Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer. (PubMed, J Clin Med)
    Lactate monitoring is a simple, cost-efficient test that can offer point-of-care results. Our data suggest that the potential of circulating lactate as a screening biomarker in OvCa merits further research attention.
    Journal
    |
    MAGEE1 (MAGE family member E1) • HCAR1 (Hydroxycarboxylic Acid Receptor 1)
    |
    MAGEE1 expression
    almost4years
    Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells. (PubMed, Gene)
    Small interfering RNA (siRNA)-mediated knockdown of HCAR1 and ATP6V0E1 showed that only knockdown of ATP6V0E1 mimicked the effect of miR-431-5p overexpression on cell viability. Our findings indicate that miR-431-5p acts as a tumour suppressor in PDAC cells, with BxPC-3 cells being most responsive.
    Journal
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    MAGEE1 (MAGE family member E1)
    |
    MAGEE1 expression