MAGEA3 overexpression

Further analysis signified that the expression of MAGEA3 mRNA was positive correlation with neutrophil, macrophages M2, dendritic cells resting, and eosinophilic, but negatively correlated with B cells, plasma cells, CD8 + T cells, CD4 + T cells, Th17 cells, macrophages and dendritic cells. Collectively, our results suggested that the MAGEA3 expression in mRNA and protein were upregulated in LUAD, and MAGEA3 could be used as a diagnostic biomarker and immunotherapy target for LUAD patients.

Multivariate analysis confirmed Survivin as independent marker for poor survival, and PHOX2B and MAGEA1 for better survival. High expression of TH, PHOX2B, and MAGEA1 genes are favorable prognostic factors for OS and EFS, whereas high expression of Survivin is associated with an increased risk of relapse or progression.

In addition, the inhibition of EMT due to the reduction of endogenous MAGEA3 by Canadine was also offset by the overexpression of exogenous MAGEA3. The study concludes that Canadine inhibits EMT of cervical cancer by inhibiting MAGEA3.

Adjuvant single-agent Doxorubicin had been applied until in September 2020 a CT scan had revealed extensive multifocal recurrent disease. Thus, second line Docetaxel and Gemcitabine had been initiated before rapid progressive disease after two cycles prompted salvage surgery... We report the case of a patient with uterine sarcoma harboring a newly described NTRK3 gene fusion partner IGDCC3 that shows a rapid clinical response to treatment with LARO.