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    BIOMARKER:

    MAFB overexpression

    i
    Other names: MAFB, MAF BZIP Transcription Factor B, V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog B, Transcription Factor MafB, KRML, MAFB/Kreisler Basic Region/Leucine Zipper Transcription Factor, V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B, Kreisler (Mouse) Maf-Related Leucine Zipper Homolog, Kreisler Maf-Related Leucine Zipper Homolog, DURS3, Maf-B, MCTO
    Entrez ID:
    9935
    Related biomarkers:
    Expression
    almost3years
    Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. (PubMed, Cell Mol Life Sci)
    Indeed, gene silencing experiments on human macrophages evidenced that MAFB is required for the LXR inhibitor to enhance the anti-inflammatory nature of human macrophages. As a whole, our results demonstrate that LXR inhibition prompts the acquisition of an anti-inflammatory transcriptional and functional profile of human macrophages in a MAFB-dependent manner, and propose the use of LXR antagonists as potential therapeutic alternatives in macrophage re-programming strategies during inflammatory responses.
    Journal
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    MAFB (MAF BZIP Transcription Factor B) • MAF (MAF BZIP Transcription Factor)
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    MAFB overexpression