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    GENE:

    MAF1 (MAF1 Homolog, Negative Regulator Of RNA Polymerase III)

    i
    Other names: MAF1, MAF1 Homolog, Negative Regulator Of RNA Polymerase III, Repressor Of RNA Polymerase III Transcription MAF1 Homolog, DKFZp586G1123, MAF1 Negative Regulator Of RNA Polymerase III, MAF1 Homolog (S. Cerevisiae), Homolog Of Yeast MAF1
    3ms
    Aurora-A-mediated cytosolic localization of Maf1 promotes cell proliferation via regulating mitochondrial function in HCC. (PubMed, Cell Death Discov)
    Furthermore, HCC cells with overexpressed Maf1 have heightened sensitivity to Aurora-A inhibitors, suggesting a potential therapeutic vulnerability. Our study uncovers a non-canonical, oncogenic role of Maf1 in HCC and highlights the Aurora-A-Maf1 axis as a promising target for personalized cancer therapy.
    Journal
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    MAF1 (MAF1 Homolog, Negative Regulator Of RNA Polymerase III)
    over2years
    MAF1 is a predictive biomarker in HER2 positive breast cancer. (PubMed, PLoS One)
    In HER2-positive breast cancer patients, MAF1 expression significantly increases and correlates with five years of relapse-free survival in response to trastuzumab treatment, suggesting MAF1 is a predictive biomarker in breast cancer. These data suggest a role for MAF1 alterations in HER2-positive breast cancer. More extensive studies are warranted to determine if MAF1 serves as a predictive and prognostic biomarker in breast cancer.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MAF1 (MAF1 Homolog, Negative Regulator Of RNA Polymerase III)
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    HER-2 positive • HER-2 expression
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    Herceptin (trastuzumab)