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    BIOMARKER:

    MAF1 expression

    i
    Other names: MAF1, MAF1 Homolog, Negative Regulator Of RNA Polymerase III, Repressor Of RNA Polymerase III Transcription MAF1 Homolog, DKFZp586G1123, MAF1 Negative Regulator Of RNA Polymerase III, MAF1 Homolog (S. Cerevisiae), Homolog Of Yeast MAF1
    1year
    MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment. (PubMed, J Immunother Cancer)
    Our study uncovers a novel anti-tumor immunity of MAF1 in hepatocarcinogenesis and human HCC. These findings suggest that the stimulated MAF1 could potentially improve immunotherapy in combination with immune checkpoint inhibitors in HCC patients, especially in those with an absence of T cells in HCC tissues.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • NRAS (Neuroblastoma RAS viral oncogene homolog) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • CD8 (cluster of differentiation 8) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CXCL10 (Chemokine (C-X-C motif) ligand 10)
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    PD-L1 overexpression • NRAS overexpression • AKT1 overexpression • MAF1 expression • MAF1 overexpression