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    BIOMARKER:

    MACC1-AS1 overexpression

    i
    Other names: MACC1-AS1, MACC1 Antisense RNA 1, MACC1-AS1, MACC1 Antisense RNA 1 (Non-Protein Coding)
    Entrez ID:
    100874041
    almost2years
    LncRNA MACC1-AS1 induces gemcitabine resistance in pancreatic cancer cells through suppressing ferroptosis. (PubMed, Cell Death Discov)
    These findings suggested that the long non-coding RNA MACC1-AS1 could play a significant role in the ability of pancreatic cancer cells to evade iron-mediated ferroptosis induced by gemcitabine. This discovery holds promise for developing clinical therapeutic strategies to combat chemotherapy resistance in pancreatic cancer.
    Journal
    |
    MDM4 (The mouse double minute 4) • GPX4 (Glutathione Peroxidase 4) • MACC1 (MET Transcriptional Regulator MACC1) • MACC1-AS1 (MACC1 Antisense RNA 1)
    |
    MACC1 overexpression • MACC1-AS1 overexpression
    |
    gemcitabine
    4years
    IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway. (PubMed, Clin Transl Oncol)
    IFN-γ affected PC properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway, which provides novel insight for candidate targets for treating PC.
    Journal
    |
    IFNG (Interferon, gamma) • MACC1 (MET Transcriptional Regulator MACC1) • MACC1-AS1 (MACC1 Antisense RNA 1)
    |
    IFNG expression • ITGAM expression • MACC1 overexpression • MACC1-AS1 overexpression