Lymphoma

P2, N=31, Not yet recruiting, Ruijin Hospital

P1, N=20, Not yet recruiting, City of Hope Medical Center

Undetectable IgE is a readily available biomarker that in a patient with CVID may direct clinicians to be particularly vigilant for non-infectious complications of CVID.

Remarkably, combined ablation caused almost complete loss of hepatic Shp expression, upregulation of the rate-limiting BA synthesis enzyme CYP7A1, severe elevation in BA levels, and cholestatic liver damage. Together, these findings reveal BCL6 as a key modulator of FXR enterohepatic signaling to maintain BA homeostasis and protect the liver from cholestatic injury.

Mechanistically, OCA suppressed inflammation via downregulation of TLR4/MYD88/NF-κB signalling, inhibited pyroptosis through TXNIP/NLRP3/ASC/caspase-1 pathway blockade and reduced p53-mediated apoptosis by modulating BAX, BCL-2 and cleaved caspase-3 expression. This study provides the first evidence that OCA confers protection against CYC-induced thyroid injury by reducing oxidative stress, inflammation, pyroptosis and apoptosis.

RDD of the lung and mediastinum is rare, with a wide range of ages. Histologically, there are often lymphoid follicles with germinal centers and interstitial fibrosis or sclerosis. This together with the expression of BCL2 and CD30 in the histiocytes can lead to misdiagnosis of lymphomas or other lymphoproliferative diseases or missed diagnosis, particularly in the mediastinum. Careful histological examination for the diagnostic feature of emperipolesis together with characteristic Cyclin D1, OCT2, S100 protein, and CD68 positivity are important clues for accurate diagnosis.

This study confirms that QUE exerts a protective effect against LPS-induced PANoptosis via cGAS/STING pathway in the broiler bursa of Fabricius, thereby providing a novel theoretical basis for the application of QUE as a green feed additive. Notably, this finding underscores the potential of QUE as a natural and effective alternative to traditional antibiotics in animal feed, which is of great significance for reducing antibiotic dependence and facilitating the sustainable development of the poultry farming industry.

P1, N=41, Active, not recruiting, University of Pennsylvania | Recruiting --> Active, not recruiting

Survival analyses revealed that co-high expression of SRSF1, HNRNPF, or PTBP1 and oncogenic MYC predicts poor clinical outcomes in MCL patients. Our data describe the clinical significance of aberrant SRSF1, hnRNP F, and PTBP1 in MCL and their tumor-promoting roles via the regulation of cancer hallmarks, which could be important in understanding MCL pathogenesis and therapeutic development.

Altogether, these findings were insufficient to establish a diagnosis of pcGDTCL. We review the clinical, histopathologic, and molecular sequencing data pertaining to our rare patient as well as the recent literature on indolent CD30+LPD with gamma-delta T-cells.

P2, N=18, Suspended, Dana-Farber Cancer Institute | Trial completion date: Aug 2025 --> Mar 2026

AITL with HRS-like cells is prone to misdiagnosis as CHL due to overlapping morphological and immunophenotypic features. Integration of EBER, TCR/IG clonality assessment, and molecular profiling, particularly the identification of TET2 and RHOA mutations is essential for accurate classification. Recognizing this entity is critical for avoiding diagnostic pitfalls and guiding appropriate therapeutic strategies.