Lung adenocarcinomas with PIK3CA mutations exhibit distinct clinicopathological characteristics in terms of gender, age, smoking history, differentiation degree, and clinical stage. Acquired drug resistance in lung adenocarcinoma may be accompanied by PIK3CA mutations, but PIK3CA mutation is not the main mechanism of targeted therapy resistance in lung adenocarcinoma patients.

3 days ago

Journal

EGFR (Epidermal growth factor receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)

EGFR mutation • PIK3CA mutation • EGFR exon 20 insertion • EGFR exon 20 mutation

Prognostic biomarkers for lung adenocarcinoma based on Mendelian randomization analysis. (PubMed, J Int Med Res)

We observed that survival was significantly higher in the groups with high expressions of ANGPT1 and CD36 than in those with low expressions of these genes. POU2AF1 demonstrated inconsistency with the results obtained using Kaplan-Meier analysis and lacked statistical significance in the GSE130779 cohort.ConclusionOur results confirmed two specific target genes, CD36 and ANGPT1, based on Mendelian randomization analysis, providing new insights into the role of these target genes in mediating the development of lung adenocarcinoma.

3 days ago

Journal

CD36 (thrombospondin receptor) • POU2AF1 (POU Class 2 Homeobox Associating Factor 1)

Doxycycline Use in Lung CancEr (DULCE) (ACTRN12625000697482)

P2, N=58, Recruiting, University of Technology Sydney | Not yet recruiting --> Recruiting

3 days ago

Enrollment open • Trial initiation date

Primary Hepatoid Adenocarcinoma of the Lung With Signet Ring Cell Differentiation and Widespread Osseous Metastases: A Case Report. (PubMed, Respirol Case Rep)

The patient received 3 cycles of gemcitabine plus carboplatin but experienced rapid clinical deterioration. This case underscores that HAL may mimic nonresolving pneumonia and that normal AFP does not exclude the diagnosis; early biopsy and a targeted immunohistochemical panel are essential for timely recognition of this lethal entity.

3 days ago

Journal

CEACAM5 (CEA Cell Adhesion Molecule 5) • AFP (Alpha-fetoprotein) • NKX2-1 (NK2 Homeobox 1) • CDX2 (Caudal Type Homeobox 2) • TP63 (Tumor protein 63)

carboplatin • gemcitabine

An Epithelial-Mesenchymal Transition-Based Prognostic Model for Survival Prediction in Lung Adenocarcinoma: COL5A2 and ZEB2. (PubMed, Curr Gene Ther)

We developed an EMT-related prognostic model and a non-invasive assessment nomogram for LUAD patients, hoping to facilitate personalized therapy for LUAD.

3 days ago

Journal

ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • COL5A2 (Collagen Type V Alpha 2 Chain)

Single-cell and spatial transcriptomic profiling of POU5F1 in Lung Adenocarcinoma: Dynamics, spatial niche, and prognosis via multi-algorithm ML. (PubMed, Transl Oncol)

POU5F1 promotes LUAD progression by maintaining stemness, reprogramming CAFs, and shaping immune evasion, representing a promising biomarker and therapeutic target.

3 days ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • CASP3 (Caspase 3) • POU5F1 (POU Class 5 Homeobox 1) • VIM (Vimentin) • NANOG (Nanog Homeobox)

Hepatoid adenocarcinoma of the lung: clinicopathologic and molecular analysis of 17 cases. (PubMed, Virchows Arch)

In summary, HAL is a distinct subtype with characteristic morphologic and immunohistochemical features. Given its aggressive clinical course, accurate diagnosis is essential for patient management.

4 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • STK11 (Serine/threonine kinase 11) • NKX2-1 (NK2 Homeobox 1)

Individualized duration of adjuvant alectinib therapy and rechallenge efficacy in ALK-positive non-small cell lung cancer: a case report. (PubMed, Front Med (Lausanne))

Further research is needed to validate these approaches in larger cohorts. Furthermore, the favorable response to alectinib rechallenge observed in this case suggests that rechallenge therapy may offer a potential value in managing post-adjuvant recurrence, which warrants further investigation.

4 days ago

Journal

ALK (Anaplastic lymphoma kinase)

ALK positive • ALK rearrangement

Alecensa (alectinib)

Paradoxical Pyogenic Granuloma Associated With Ramucirumab but Not Bevacizumab: A Case Suggesting Differential Effects of VEGF Receptor and Ligand Inhibition. (PubMed, Respirol Case Rep)

We describe a 75-year-old man with advanced lung adenocarcinoma who developed multiple bleeding pyogenic granulomas during docetaxel plus ramucirumab therapy. This intra-patient contrast suggests that VEGFR-2 blockade and VEGF ligand inhibition may have different effects on paradoxical vascular proliferative lesions. Clinicians should recognize this rare toxicity and consider switching anti-angiogenic strategy in selected cases.

4 days ago

Journal

KDR (Kinase insert domain receptor)

Avastin (bevacizumab) • docetaxel • Cyramza (ramucirumab)

EGFR-19del nuclear translocation increases HDAC7 expression inhibiting the Hippo pathway and exacerbating TKI resistance in lung adenocarcinoma. (PubMed, Theranostics)

Concurrently, nuclear EGFR-19del acts as a coactivator to accelerate HDAC7 transcription through signal transducer and activator of transcription 3 (STAT3). We elucidated the underlying mechanism by which nuclear EGFR-19del inhibits the Hippo pathway; these results indicate that TKIs and HDAC inhibitors may serve as a potential therapeutic strategy to reduce drug resistance in LUAD with EGFR-19del.

4 days ago

Journal

EGFR (Epidermal growth factor receptor) • STAT3 (Signal Transducer And Activator Of Transcription 3) • LATS1 (Large Tumor Suppressor Kinase 1) • HDAC7 (Histone Deacetylase 7)

EGFR exon 19 deletion

Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion. (PubMed, Chin Med)

SSG could dose-dependently inhibit LLC tumor growth in mice and exert antitumor effects by alleviating T-cell exhaustion and MDSC-mediated immunosuppression. Notably, IL2, STAT3, HSP90AA1, LGALS3 and FGF2, as potential targets of SSG, were significantly enriched in the PI3K-Akt pathway, which provide a novel perspective for the treatment of LUAD.

4 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • FGF2 (Fibroblast Growth Factor 2) • LGALS3 (Galectin 3) • TGFB1 (Transforming Growth Factor Beta 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)