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    GENE:

    LRWD1 (Leucine Rich Repeats And WD Repeat Domain Containing 1)

    i
    Other names: LRWD1, Leucine Rich Repeats And WD Repeat Domain Containing 1, CENP-33, ORCA, Centromere Protein 33, Leucine-Rich Repeat And WD Repeat-Containing Protein 1, Origin Recognition Complex-Associated Protein, ORC-Associated Protein, DKFZp434K1815, Origin Recognition Complex Associated, Testicular Tissue Protein Li 4
    Associations

    News

    Trials
    2years
    MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells. (PubMed, Aging (Albany NY))
    This is the first study showing the role of miR-320a in upregulating the testicular cancer-specific regulator LRWD1 and the importance of the AGO2/FXR1 complex in miR-320a-mediated upregulation of LRWD1 during testicular cancer progression.
    Journal
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    MIR320A (MicroRNA 320a) • LRWD1 (Leucine Rich Repeats And WD Repeat Domain Containing 1)
    over3years
    Knockdown of circLRWD1 weakens DDP resistance via reduction of SIRT5 expression through releasing miR-507 in non-small cell lung cancer. (PubMed, Anticancer Drugs)
    Cisplatin (DDP) is an antineoplastic agent for non-small cell lung cancer (NSCLC)...SIRT5 overexpression weakened circLRWD1 silencing-mediated suppression of cell resistance to DDP in DDP-resistant NSCLC cells. In conclusion, circLRWD1 elevated SIRT5 expression via adsorbing miR-507, resulting in promoting NSCLC cell resistance to DDP, providing evidence to explain the significant role of circLRWD1 in DDP resistance in NSCLC.
    Journal
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    LRWD1 (Leucine Rich Repeats And WD Repeat Domain Containing 1) • SIRT5 (Sirtuin 5)
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    cisplatin