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    GENE:

    LRRFIP1 (LRR Binding FLII Interacting Protein 1)

    i
    Other names: LRRFIP1, LRR Binding FLII Interacting Protein 1, TRIP, GCF2, GC-Binding Factor 2, FLIIAP1, FLAP-1, HUFI-1, GCF-2, Leucine-Rich Repeat Flightless-Interacting Protein 1, Leucine Rich Repeat (In FLII) Interacting Protein 1, LRR FLII-Interacting Protein 1, TAR RNA-Interacting Protein, NEDD8-Conjugating Enzyme, FLAP1
    Associations

    News

    Trials
    6ms
    Single-cell RNA sequencing reveals immune regulatory mechanisms and molecular therapeutic strategies in the microenvironment of multiple myeloma. (PubMed, Int J Surg)
    This study reveals key genetic drivers and immune modulation mechanisms in MM. Targeting immune-related pathways, such as PI3K-AKT-mTOR and WNT-β-catenin, and small molecules targeting ISG15 and TAGLN2 could offer new therapeutic strategies.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TGFB1 (Transforming Growth Factor Beta 1) • CTSS (Cathepsin S) • HLA-C (Major Histocompatibility Complex, Class I, C) • LRRFIP1 (LRR Binding FLII Interacting Protein 1)
    9ms
    LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome. (PubMed, J Transl Med)
    LRRFIP1 can promote the proliferation of MDS cells and inhibit apoptosis, and LRRFIP1 and Dvl can synergistically enhance the activity of the Wnt/β-catenin signaling pathway in MDS, thus providing evidence for LRRFIP1's involvement in the pathogenesis of MDS.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • ANXA5 (Annexin A5) • LRRFIP1 (LRR Binding FLII Interacting Protein 1)
    1year
    Analysis of TNS3-203 and LRRFIP1-211 Transcripts as Oral Cancer Biomarkers. (PubMed, J Oral Pathol Med)
    The results obtained indicate the diagnostic potential of TNS3-203, but not LRRFIP1-211 transcript and its role in oral carcinogenesis.
    Journal
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    TNS3 (Tensin 3) • LRRFIP1 (LRR Binding FLII Interacting Protein 1)
    1year
    Radial Data Visualization-Based Step-by-Step Eliminative Algorithm to Predict Colorectal Cancer Patients' Response to FOLFOX Therapy. (PubMed, Int J Mol Sci)
    Additionally, the procedure developed based on expression levels of TMEM182, MCM9, LRRFIP1, LAMP1, FAM161A, KLHL36, ETV5, RNF168, SRSF11, NCKAP5, CRTAP, VAMP2, ZBTB49 and RIMBP2 proved to be capable in predicting FOLFOX therapy response. In conclusion, our approach can give a unique insight into clinical decision-making regarding therapy scheme administration, potentially increasing patients' survival and, consequently, medical futility due to incorrect therapy application.
    Journal
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    LAMP1 (Lysosomal Associated Membrane Protein 1) • ETV5 (ETS Variant Transcription Factor 5) • MCM9 (Minichromosome Maintenance 9 Homologous Recombination Repair Factor) • VAMP2 (Vesicle Associated Membrane Protein 2) • LRRFIP1 (LRR Binding FLII Interacting Protein 1) • RNF168 (Ring Finger Protein 168)
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    5-fluorouracil • oxaliplatin • leucovorin calcium
    almost2years
    The clinical significance and oncogenic function of LRRFIP1 in pancreatic cancer. (PubMed, Discov Oncol)
    Taken together, LRRFIP1 is associated with tumorigenesis, immune cell infiltration, and prognosis in pancreatic cancer, which suggests that LRRFIP1 may be a potential biomarker and therapeutic target for pancreatic cancer.
    Journal
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    LRRFIP1 (LRR Binding FLII Interacting Protein 1)
    over2years
    Immune micro-environment analysis and establishment of response prediction model for PD-1 blockade immunotherapy in glioblastoma based on transcriptome deconvolution. (PubMed, J Cancer Res Clin Oncol)
    ITGAX, LRRFIP1 and FMN1 were identified as the response prediction genes of PD-1 inhibitors and the response prediction model based on them was proved to have potential clinical value.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • ITGAX (Integrin Subunit Alpha X) • LRRFIP1 (LRR Binding FLII Interacting Protein 1)
    over2years
    Acute myeloid leukemia with LRRFIP1::FGFR1 rearrangement and a complex karyotype. (PubMed, Cancer Genet)
    NGS Archer FusionPlex (RNA) confirmed the LRRFIP1::FGFR1 rearrangement. This is the second reported case of AML with LRRFIP1::FGFR1 rearrangement and the first with a complex karyotype.
    Journal
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    FGFR1 (Fibroblast growth factor receptor 1) • RUNX1 (RUNX Family Transcription Factor 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • LRRFIP1 (LRR Binding FLII Interacting Protein 1)
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    FGFR1 amplification • RUNX1 mutation • FGFR1 fusion • Chr del(5q) • FGFR1 rearrangement