LRP1B overexpression

Further investigation demonstrated that silencing LRP1B expression enhanced the sensitivity of HCC cells to doxorubicin...Additionally, we probed the genomic alterations of LRP1B in HCC and the impact on the prognosis of patients. Collectively, our results suggest that LRP1B plays an essential role in the promotion of HCC progression by regulating the PERK-ATF4-CHOP signaling pathway, which is a potential prognostic biomarker and a promising therapeutic target of HCC.

This study is the first to report that a single gene LRP1B mutation is associated with a poor clinical response to ICI treatment and negative outcomes in HCC patients. HighLRP1B expression correlated with tumor immunity and HCC prognosis.

In our study, LRP1B expression was increased in tumors from older patients and in tumors with aggressive characteristics. LRP1B mutations have been associated with both high tumor mutational burdens and ultraviolet damage, which may explain these findings(5,6). Additional studies with larger sample sizes should continue to investigate the role of LRP1B in SCC progression and metastasis.