our Premium Content: News alerts, weekly reports and conference planners
BIOMARKER:
LRP1B deletion
i
Other names: Low density lipoprotein-related protein 1B, LRPDIT, LRP1B, LDL receptor related protein 1B, Low-density lipoprotein receptor-related protein 1B, LRP-1B
Contact us to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Proteomic analysis of the clones' secretome identified differentially expressed proteins that had not been previously associated with LRP1B alterations. This study demonstrates that the dual sgRNA CRISPR/Cas9 strategy can effectively edit LRP1B in GB cells, providing new insights into the impact of LRP1B deletions in GBM biology.
Further investigation demonstrated that silencing LRP1B expression enhanced the sensitivity of HCC cells to doxorubicin...Additionally, we probed the genomic alterations of LRP1B in HCC and the impact on the prognosis of patients. Collectively, our results suggest that LRP1B plays an essential role in the promotion of HCC progression by regulating the PERK-ATF4-CHOP signaling pathway, which is a potential prognostic biomarker and a promising therapeutic target of HCC.
2 years ago
Journal
|
LRP1B (LDL Receptor Related Protein 1B) • ATF4 (Activating Transcription Factor 4)