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    DRUG:

    cafelkibart (LM-108)

    i
    Other names: LM-108, LM 108, LM108
    Associations

    News

    Trials
    Company:
    Sino Biopharm
    Drug class:
    CCR8 inhibitor
    Related drugs:
    Associations

    News

    Trials
    2d
    A Study of LM-108 as Monotherapy or in Combination With Antitumor Therapies in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=392, Active, not recruiting, LaNova Medicines Limited | Trial completion date: Dec 2025 --> Mar 2026 | Trial primary completion date: Dec 2025 --> Mar 2026
    Trial completion date • Trial primary completion date • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    Loqtorzi (toripalimab-tpzi) • cafelkibart (LM-108)
    14d
    LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gastric and Gastroesophageal Junction Adenocarcinoma (clinicaltrials.gov)
    P3, N=400, Not yet recruiting, LaNova Medicines Limited
    New P3 trial
    |
    HER-2 (Human epidermal growth factor receptor 2) • CCR8 (C-C Motif Chemokine Receptor 8)
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    HER-2 negative • HER-2 expression
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    paclitaxel • Loqtorzi (toripalimab-tpzi) • cafelkibart (LM-108)
    2ms
    Clinical Studies for the Treatment of Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=194, Recruiting, Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | N=134 --> 194
    Enrollment change
    |
    Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin • Anniko (penpulimab-kcqx) • cafelkibart (LM-108)
    5ms
    Study of LM-108 as a Single Agent or in Combination With Toripalimab in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=392, Active, not recruiting, LaNova Medicines Limited | Enrolling by invitation --> Active, not recruiting | Trial primary completion date: Jul 2025 --> Dec 2025
    Enrollment closed • Trial primary completion date
    |
    Loqtorzi (toripalimab-tpzi) • cafelkibart (LM-108)
    5ms
    Study of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=78, Completed, LaNova Australia Pty Limited | Recruiting --> Completed | N=60 --> 78
    Trial completion • Enrollment change • First-in-human
    |
    cafelkibart (LM-108)
    10ms
    Clinical Studies for the Treatment of Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=134, Recruiting, Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin • Anniko (penpulimab-kcqx) • cafelkibart (LM-108)
    11ms
    A Study of LM-108 in Combination With Toripalimab in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P2, N=84, Not yet recruiting, LaNova Medicines Limited
    New P2 trial • Mismatch repair • IO biomarker
    |
    Loqtorzi (toripalimab-tpzi) • cafelkibart (LM-108)
    over1year
    Study of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=60, Recruiting, LaNova Australia Pty Limited | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Mar 2024 --> Dec 2024
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    cafelkibart (LM-108)
    over1year
    Study of LM-108 as a Single Agent or in Combination With Toripalimab in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=392, Enrolling by invitation, LaNova Medicines Limited | Recruiting --> Enrolling by invitation
    Enrollment status • Combination therapy • Metastases
    |
    Loqtorzi (toripalimab-tpzi) • cafelkibart (LM-108)
    over2years
    Study of LM-108 as a Single Agent or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=24, Terminated, LaNova Medicines Limited | N=54 --> 24 | Trial completion date: Dec 2023 --> Aug 2023 | Recruiting --> Terminated | Trial primary completion date: Nov 2023 --> Aug 2023; Completed primary objective.
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Combination therapy • Metastases
    |
    Keytruda (pembrolizumab) • cafelkibart (LM-108)
    over2years
    Study of LM-108 as a Single Agent or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=54, Recruiting, LaNova Medicines Limited | Trial completion date: Sep 2024 --> Dec 2023 | Trial primary completion date: Jul 2024 --> Nov 2023
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    Keytruda (pembrolizumab) • cafelkibart (LM-108)
    almost4years
    Effective depletion of tumor-infiltrating Tregs by a novel anti-CCR8 antibody (LM-108): Addressing resistance associated with immune checkpoint inhibitors (AACR 2022)
    To conclude, LM-108 is a novel Fc-optimized CCR8 antibody that selectively depletes tumor infiltrating Tregs thereby improving anti-tumor immune response either as monotherapy or combination therapy. Thus, LM-108 can be a promising therapeutic approach to overcome ICI resistance in cancer patients.
    Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CCR4 (C-C Motif Chemokine Receptor 4) • FOXP3 (Forkhead Box P3) • CCR8 (C-C Motif Chemokine Receptor 8)
    |
    CCR8 expression • FOXP3 expression
    |
    cafelkibart (LM-108)