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LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

News alerts, weekly reports and conference planners

Construction of an Immunogenic Cell Death-Related Long Non-Coding RNA Signature for Predicting Prognosis in Osteosarcoma. (PubMed, Crit Rev Immunol)

The signature demonstrated significant prognostic predictive power, confirmed by receiver operating characteristic curve analysis, and functioned as an independent prognostic factor. Moreover, the signature reflects the tumor immune microenvironment and predicts distinct chemotherapy responses, guiding OS treatment strategies.

5 days ago

Journal

LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

21d

m5c-modified LINC01094 participates in epithelial-mesenchymal transition and metastasis of cervical cancer cells via the ZNF582-SIRT1/p53 axis. (PubMed, Mamm Genome)

Collectively, NSUN2-mediated stabilization of LINC01094 upregulated SIRT1 expression, thereby suppressing the p53 pathway and accelerating CC progression. These findings uncover a novel NSUN2/LINC01094/SIRT1 axis as an epigenetic-transcriptional driver of CC, offering potential therapeutic targets.

21 days ago

Journal

LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

22d

Implications of LINC01094 for human malignancies. (PubMed, PeerJ)

Numerous recently published reports have shown that LINC01094 exerts critical functions during the regulation of malignant cell growth, migrating ability, and invasiveness, thereby controlling cancer cell growth and metastasis. In this review, multiple cancer biology functions of LINC01094 documented in published literature are summarized, aiming to inspire innovations in the management of human malignancies under laboratory and clinical settings.

22 days ago

Review • Journal

PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

Mechanistic roles of long non-coding RNAs in gastric cancer therapy resistance. (PubMed, Noncoding RNA Res)

Although current research remains exploratory, lncRNAs show significant promise as predictive biomarkers and therapeutic targets. Future personalized strategies intergrating lncRNA profiles could help overcome drug resistance and improve patient outcomes.

1 month ago

Review • Journal • PD(L)-1 Biomarker • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • HOTAIR (HOX Transcript Antisense RNA) • HNF1A (HNF1 Homeobox A) • LINC00665 (Long Intergenic Non-Protein Coding RNA 665) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR4435-2HG (MIR4435-2 Host Gene) • CRNDE (Colorectal Neoplasia Differentially Expressed)

PD-L1 expression

5-fluorouracil

6ms

The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Factors in Colorectal Cancer. (PubMed, Cancers (Basel))

Selected lncRNAs, including THOR and LINC01094, have also demonstrated significant prognostic value. Despite these advances, challenges persist, including inconsistent reporting, limited external validation, and a lack of replication by independent research groups.

6 months ago

Review • Journal

ERCC1 (Excision repair cross-complementation group 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR21 (MicroRNA 21) • GAS6 (Growth arrest specific 6) • MIR211 (MicroRNA 211) • IGFBP3 (Insulin-like growth factor binding protein 3) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR140 (MicroRNA 140) • MIR150 (MicroRNA 150) • MIR215 (MicroRNA 215) • MIR675 (MicroRNA 675) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SNHG14 (Small Nucleolar RNA Host Gene 14) • ASB16-AS1 (ASB16 Antisense RNA 1)

7ms

Risk score model with two immune infiltration-related long non-coding RNAs to predict prognosis in patients with osteosarcoma. (PubMed, Oncol Lett)

In summary, two IIRLs were developed in the present study to predict prognosis in patients with OS. The molecular mechanisms in the high-risk group may influence immune infiltration-linked biological processes.

7 months ago

Journal • IO biomarker

LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

7ms

LINC01094 targets miR-1266-5p to halt neoplasm progression of cervical cancer. (PubMed, J Obstet Gynaecol)

Low LINC01094 expression in patient with CC is a risk factor for prognosis. Overexpression of LINC01094 targeting miR-1266-5p prevents the progression of CC neoplasm.

7 months ago

Journal

LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

9ms

METTL14-Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex. (PubMed, Adv Sci (Weinh))

Furthermore, the therapeutic potential of LINC01094 is evaluated through the administration of the PKM2 activator TEPP-46 in mouse xenografts. These findings highlight the critical roles of LINC01094 in cellular glucose metabolism and tumorigenesis in BC, suggesting that it is a potential therapeutic target.

9 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • METTL14 (Methyltransferase 14) • PKM (Pyruvate Kinase M1/2)

9ms

This comprehensive analysis of lactate-related genes reveals how this gene signature may shape the tumor microenvironment and affect BLCA patient prognosis. Additionally, our data suggest that targeting LINC01094 with antisense oligonucleotides (ASOs) could reduce BLCA cell metastasis and enhance their sensitivity to chemotherapy.

9 months ago

Journal • IO biomarker

LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

1year

LINC01094 promotes gastric cancer through dual targeting of CDKN1A by directly binding RBMS2 and HDAC1. (PubMed, Biol Direct)

The LINC01094-miR-128-3p-RUNX1 feedback loop downregulates CDKN1A and promotes GC cooperatively with RBMS2 and HDAC1. Furthermore, Ro 5-3335 may hold promising therapeutic potential in the treatment of GC. Hence, our study found an oncogenic lncRNA, LINC01094, which could be a promising target for cancer treatment and diagnosis.

1 year ago

Journal

RUNX1 (RUNX Family Transcription Factor 1) • HDAC1 (Histone Deacetylase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR128 (MicroRNA 128) • RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2)

over1year

The LINC01094/miR-545-3p/SLC7A11 Signaling Axis Promotes the Development of Gastric Cancer by Regulating Cell Growth and Ferroptosis. (PubMed, Biochem Genet)

These findings indicate that miR-545-3p could target and positively correlate with SLC7A11 expression. Additionally, LINC01094 could promote GC cell progression and affect cellular ferroptosis by regulating the miR-545-3p/SLC7A11 signaling axis.

over 1 year ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • CASP3 (Caspase 3) • SLC7A11 (Solute Carrier Family 7 Member 11) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR545 (MicroRNA 545)

BCL2 expression • CCND1 expression • SLC7A11 expression

over1year

Identification of lncRNA dual targeting PD-L1 and PD-L2 as a novel prognostic predictor for gastric cancer. (PubMed, Front Oncol)

LINC01094 dually regulates the expression of PD-L1 and PD-L2 and shapes the immunosuppressive tumor microenvironment via sponging miR-17-5p. LINC01094 may serve as a potential prognostic predictor and therapeutic target in GC.

over 1 year ago

Journal • PD(L)-1 Biomarker • IO biomarker

MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • PD-L2 (Programmed Cell Death 1 Ligand 2) • IL10 (Interleukin 10) • MIR17 (MicroRNA 17) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094)

PD-L1 expression • PD-L2 expression