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    BIOMARKER:

    LINC00963 overexpression

    i
    Other names: LINC00963, Long Intergenic Non-Protein Coding RNA 963, MetaLnc9, NONHSAG053586.2, HSALNG0074744, HSALNG0074742, LINC00963
    Entrez ID:
    100506190
    almost2years
    Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. (PubMed, Biochim Biophys Acta Gene Regul Mech)
    At cellular levels, LINC00963-v2/-v3 overexpression suppressed cell proliferation, viability, and migration while increasing the apoptosis of CRC cell lines, detected by PI flow cytometry, colony formation, MTT, RT-qPCR, wound-healing, Transwell, AnnexinV-PE/7AAD, caspase3/7 activity assays, and Hoechst/PI-AO/EB staining. Overall, our results indicate that LINC00963-v2 & -v3 are novel tumor suppressor ceRNAs that attenuate the PI3K and Wnt pathways during CRC incidence and these lncRNAs may serve as potential targets for CRC therapy.
    Journal
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    PTEN (Phosphatase and tensin homolog) • CASP3 (Caspase 3) • LINC00963 (Long Intergenic Non-Protein Coding RNA 963) • AXIN1 (Axin 1) • CASP7 (Caspase 7) • MIR143 (MicroRNA 143) • ANXA5 (Annexin A5) • MIR217 (MicroRNA 217)
    |
    LINC00963 overexpression
    almost2years
    LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization. (PubMed, Mol Med)
    By stabilizing Zeb1 in cancer cells and delivering exosomes to induce M2 macrophage polarization, LINC00963 promoted the malignancy and metastasis of LUAD. Targeting LINC00963 may become a valuable therapeutic target for LUAD.
    Journal
    |
    LINC00963 (Long Intergenic Non-Protein Coding RNA 963) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1)
    |
    LINC00963 overexpression
    over2years
    LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer. (PubMed, Med Sci Monit)
    CONCLUSIONS Our results confirmed the association of significantly high levels of LINC00963 expression in CESC with several observed clinical features. LINC00963 may be a potentially useful prognostic molecular biomarker associated with poor survival in patients with CESC.
    Journal • IO biomarker
    |
    LINC00963 (Long Intergenic Non-Protein Coding RNA 963)
    |
    LINC00963 overexpression