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GENE:

LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

News alerts, weekly reports and conference planners

3ms

METTL3-mediated m6A modification of LINC00857 enhances stemness and metastasis of ovarian cancer cells by activating the YAP-TEAD pathway. (PubMed, Sci Rep)

Moreover, there was interaction between METTL3 and LINC00857. METTL3-mediated N6-methyladenosine modification of LINC00857 enhanced metastasis and stemness of OC cells via activating the YAP-TEA domain transcription factor pathway.

3 months ago

Journal

METTL3 (Methyltransferase Like 3) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

8ms

A novel non-invasive mRNA-lncRNA biomarker panel for accurate prediction of cervical squamous cell carcinoma and adenocarcinoma. (PubMed, J Gynecol Oncol)

Notably, this tissue-based biomarker panel robustly discriminated precancerous lesion and cervical cancer patients from non-disease controls in a blood-based validation set (30 normal, 25 HSIL and 50 cervical cancer) with an AUC value of 0.9320. This study presents a non-invasive, efficient diagnostic panel for cervical cancer screening.

8 months ago

Journal

ITGB6 (Integrin Subunit Beta 6) • HOXC6 (Homeobox C6) • WDR62 (WD Repeat Domain 62) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

10ms

Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin. (PubMed, Tob Induc Dis)

NNK potentially induces PC progression through the LINC00857/β-catenin axis. These findings provide new perspectives on the mechanisms of PC progression and highlight the clinical relevance of smoking cessation for preventing PC.

10 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

10ms

Evaluation of specific lncRNAs, miRNAs, and mRNAs in different groups of prostate cancer. (PubMed, Bioimpacts)

Our results identified promising biomarkers that play a role in specific groups of prostate cancer patients. Detecting specific biomarkers may be an effective strategy for different groups of PC patients.

10 months ago

Journal

CDH1 (Cadherin 1) • CD24 (CD24 Molecule) • GNAS (GNAS Complex Locus) • MIR152 (MicroRNA 152) • MIR27B (MicroRNA 27b) • MIR375 (MicroRNA 375) • ST14 (ST14 transmembrane serine protease matriptase) • LINC01128 (Long Intergenic Non-Protein Coding RNA 1128) • MIR203A (MicroRNA 203a) • MIR217 (MicroRNA 217) • MIR876 (MicroRNA 876) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

over1year

Apigenin suppresses the low oxaliplatin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells via LINC00857. (PubMed, Transl Cancer Res)

Furthermore, the tumor-promoting effects induced by low-dose OXA were notably suppressed through LINC00857. Evidence from this study indicates that apigenin can effectively suppress the metastasis of OSCC cancer cells induced by low-dose OXA through inhibiting the level of LINC00857, suggesting a promising therapeutic strategy.

over 1 year ago

Journal

LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

oxaliplatin

almost2years

Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis. (PubMed, Clin Respir J)

Subsequently, the downstream factors, miR-486-5p and NEK2, were screened, and the putative regulatory axis was examined. Overall, the regulatory effect of methylation-mediated LINC00857 overexpression on miR-486-5p/NEK2 axis may be a new mechanism for LUAD progression.

almost 2 years ago

Journal

MIR486-1 (MicroRNA 486-1) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

almost2years

The prognostic value of sialylation-related long non-coding RNAs in lung adenocarcinoma. (PubMed, Sci Rep)

By integrating multi-omics data, we identified four core sialylation-related lncRNAs and successfully established a prognostic model to distinguish patients with different characterizations. These findings may provide some insights into the underlying mechanism of sialylation, and offer a new stratification way as well as clinical guidance in LUAD.

almost 2 years ago

Journal • Tumor mutational burden

TMB (Tumor Mutational Burden) • ITGA9 (Integrin Subunit Alpha 9) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

almost2years

FOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis. (PubMed, Cell Death Dis)

Additionally, the FOXP3 inhibitor epirubicin exhibited the ability to impede proliferation and induce ferroptosis in GBM cells both in vitro and in vivo. In summary, our study provided evidences that FOXP3 facilitates the progression of glioblastoma by inhibiting ferroptosis via the linc00857/miR-1290/GPX4 axis, highlighting FOXP3 as a potential therapeutic target for GBM.

almost 2 years ago

Journal

GPX4 (Glutathione Peroxidase 4) • FOXP3 (Forkhead Box P3) • MIR1290 (MicroRNA 1290) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

epirubicin

almost2years

Integrated analysis identifies cuproptosis-related gene DLAT and its competing endogenous RNAs network to predict the prognosis of pancreatic adenocarcinoma patients. (PubMed, Medicine (Baltimore))

Furthermore, ceRNA network analysis suggested the involvement of the LINC00857/has-miR-1179/DLAT axis in the development of PAAD. Overall, this study provides theoretical support for the investigation of diagnostic and prognostic biomarkers as well as potential therapeutic targets in PAAD.

almost 2 years ago

Journal

DLAT (Dihydrolipoamide S-Acetyltransferase) • LIAS (Lipoic Acid Synthetase) • LIPT1 (Lipoyltransferase 1) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)

over2years

Establishment of a novel signature to predict prognosis and immune characteristics of pancreatic cancer based on necroptosis-related long non-coding RNA. (PubMed, Mol Biol Rep)

The novel 5-NRL signature is helpful for assessing the prognosis of PC patients and improving therapy options, so it can be further applied clinically.

over 2 years ago

Journal • Tumor mutational burden • IO biomarker

TMB (Tumor Mutational Burden) • PTPRN (Protein Tyrosine Phosphatase Receptor Type N) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)