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    GENE:

    LINC00265 (Long Intergenic Non-Protein Coding RNA 265)

    i
    Other names: LINC00265, Long Intergenic Non-Protein Coding RNA 265, NCRNA00265-1, NCRNA00265, Non-Protein Coding RNA 265-1, Non-Protein Coding RNA 265, NONHSAG047406.2, HSALNG0057380, LINC00265
    Associations

    News

    Trials
    4ms
    Targeting the LINC00265/miR-485-5p axis for diagnosis and therapeutic intervention in breast cancer. (PubMed, Discov Oncol)
    Significantly upregulated LINC00265 is a biomarker for the diagnosis of breast cancer, and LINC00265 binds to miR-485-5p to mediate tumor progression.
    Journal
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    MIR485 (MicroRNA 485) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
    over1year
    Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene. (PubMed, Oncol Res)
    These observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung adenocarcinoma. Our findings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.
    Journal
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    LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
    over1year
    Linc00265 in human disease: A comprehensive analysis of its implications in human disease pathobiology and therapeutic prospect. (PubMed, Pathol Res Pract)
    This review aims to comprehensively analyze the expression patterns, regulatory mechanisms, and potential biomarker roles of Linc00265 in human diseases, with a particular focus on cancer. By elucidating the functional implications of Linc00265, we can deepen our understanding of its roles in human diseases, potentially paving the way for novel therapeutic interventions in disease management.
    Review • Journal
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    LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
    almost2years
    LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis. (PubMed, Immunol Invest)
    The higher expression of LINC00265 was correlated with lower cumulative patient sursvival. LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • IL17A (Interleukin 17A) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
    almost2years
    Integrated analysis of a competing endogenous RNA network reveals a ferroptosis-related 6-lncRNA prognostic signature in clear cell renal cell carcinoma. (PubMed, Adv Clin Exp Med)
    Our research underlines the role of the 6-ferroptosis-lncRNA signature as a predictor of prognosis and a therapeutic alternative for ccRCC.
    Journal
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    PVT1 (Pvt1 Oncogene) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265) • MIAT (Myocardial Infarction Associated Transcript) • SNHG17 (Small Nucleolar RNA Host Gene 17) • CYTOR (Cytoskeleton Regulator RNA)
    2years
    A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma. (PubMed, ACS Chem Neurosci)
    Moreover, LINC00265 elevated ZNF384 by sponging miR-let-7d-5p and recruiting IGF2BP2. In conclusion, LINC00265 and IFI30 act as oncogenes in glioma by driving stemness and EMT, underscoring their potential as therapeutic targets.
    Journal
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    ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265) • ZNF384 (Zinc Finger Protein 384)
    over3years
    Circulating plasma exosomal long non-coding RNAs LINC00265, LINC00467, UCA1, and SNHG1 as biomarkers for diagnosis and treatment monitoring of acute myeloid leukemia. (PubMed, Front Oncol)
    Additionally, these lncRNAs were high stability in plasma exosomes. Exosomal LINC00265, LINC00467, UCA1, and SNHG1 may act as promising cell-free biomarkers for AML diagnosis and treatment monitoring and provide a new frontier of liquid biopsy for this type of cancer.
    Journal
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    SNHG1 (Small Nucleolar RNA Host Gene 1) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
    over3years
    LINC00265 Promotes Metastasis and Progression of Hepatocellular Carcinoma by Interacting with E2F1 at The Promoter of CDK2. (PubMed, Cell J)
    LINC00265 overexpression promoted expression of CDK2 in HCC cells. Our data suggested that LINC00265 can promote malignant behaviors of HCC cells by recruiting E2F1 to the promoter region of CDK2.
    Journal
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    CDK2 (Cyclin-dependent kinase 2) • E2F1 (E2F transcription factor 1) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
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    CDK2 expression
    over3years
    Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis. (PubMed, Sci Rep)
    Furthermore, TOP2A was positively associated with expression of immune checkpoints (CD274, CTLA4, HAVCR2, LAG3, PDCD1 and TIGIT) in most cancer types. Our first TOP2A pan-cancer study contributes to understanding the prognostic roles, immunological roles and potential upstream molecular mechanism of TOP2A in different cancers.
    Journal • PD(L)-1 Biomarker • IO biomarker • Pan tumor
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    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • TOP2A (DNA topoisomerase 2-alpha) • LAG3 (Lymphocyte Activating 3) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • NUTM2A (NUT Family Member 2A) • NUTM2B (NUT Family Member 2B) • MIR142 (MicroRNA 142) • MIR139 (MicroRNA 139) • SNHG1 (Small Nucleolar RNA Host Gene 1) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)
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    LAG3 expression
    over3years
    Long Intergenic Noncoding RNA00265 Enhances Cell Viability and Metastasis via Targeting miR-485-5p/USP22 Axis in Osteosarcoma. (PubMed, Front Oncol)
    Strikingly, linc00265 exerted its oncogenic function via regulating miR-485-5p and USP22 in osteosarcoma. Taken together, targeting linc00265 is a promising approach for treating osteosarcoma patients.
    Journal
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    MIR485 (MicroRNA 485) • USP22 (Ubiquitin Specific Peptidase 22) • LINC00265 (Long Intergenic Non-Protein Coding RNA 265)