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    GENE:

    LIMS1 (LIM Zinc Finger Domain Containing 1)

    i
    Other names: LIMS1, LIM Zinc Finger Domain Containing 1, PINCH1, PINCH, Particularly Interesting New Cys-His Protein 1, LIM And Senescent Cell Antigen-Like-Containing Domain Protein 1, LIM And Senescent Cell Antigen-Like Domains 1, Renal Carcinoma Antigen NY-REN-48, LIM-Type Zinc Finger Domains 1, Senescent Cell Antigen, PINCH-1
    10ms
    Loss of lims1 causes aberrant cardiac remodeling and heart failure via activating gp130/Jak1/Stat3 pathway in zebrafish. (PubMed, J Genet Genomics)
    Strikingly, pharmacological inhibition of Stat3 or c-Fos partially rescues cardiomyopathy phenotypes. Our findings reveal the underlying mechanism of lims1 deficiency-caused heart failure through gp130/Jak1/Stat3 hyperactivation, offering insights into cardiac remodeling and potential therapeutic strategies.
    Journal
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    JAK1 (Janus Kinase 1) • LIMS1 (LIM Zinc Finger Domain Containing 1) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2)
    1year
    Interdependent roles for growth differentiation factor-15 (GDF15) and LIMS1 in regulating cell migration: Implications for colorectal cancer metastasis. (PubMed, Biochim Biophys Acta Mol Cell Res)
    Conversely, GDF15 or LIMS1-siRNA-mediated silencing in invasive HCT116 cells resulted in downregulation of LIMS1 and GDF15 respectively, decreased RAC1, and RHOA as well as reduced cell migration, which were fully restored by hrGDF15 treatment both in GDF15 and LIMS1-siRNA-treated cells. Our findings indicate that GDF15 and LIMS1 have an interdependent role in the migration process which renders them potent targets for the development of novel therapeutic strategies to inhibit metastatic spread.
    Journal
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    GDF15 (Growth differentiation factor 15) • RAC1 (Rac Family Small GTPase 1) • RHOA (Ras homolog family member A) • CDC42 (Cell Division Cycle 42) • LIMS1 (LIM Zinc Finger Domain Containing 1)
    almost2years
    The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA. (PubMed, Cancer Med)
    The investigation ascertained that RBMS3 inhibits the progression of colon cancer by regulating LIMS1. The inhibitory function of LIMS1 and RBMS3 is closely intertwined in colon cancer, with knocking down LIMS1 being able to rescue the inhibitory effect of RBMS3 overexpression on the functionality of colon cancer cell The discernments delineate RBMS3 as a novel suppressor of cancer via LIMS1, thereby bestowing fresh therapeutic possibilities and illuminating the intricacies of colon cancer.
    Journal
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    LIMS1 (LIM Zinc Finger Domain Containing 1) • RBMS3 (RNA Binding Motif Single Stranded Interacting Protein 3)