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BIOMARKER:

LIFR expression

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Other names: LIFR, LIF Receptor Subunit Alpha, Leukemia Inhibitory Factor Receptor, Leukemia Inhibitory Factor Receptor Alpha, LIF Receptor Alpha, CD118 Antigen, LIF Receptor, LIF-R, CD118, SJS2, STWS, SWS
Entrez ID:
Related biomarkers:
11d
Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis. (PubMed, Biochem Pharmacol)
In patient-derived organoids (hPDOs) from GC patients, GDCA reverses LIF-induced stemness and proliferation. In summary, we have identified the secondary bile acids as the first endogenous antagonist to LIFR supporting a development of bile acid-based therapies in LIF-mediated oncogenesis.
Journal
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IL6 (Interleukin 6) • LIFR (LIF Receptor Subunit Alpha) • LIF (LIF Interleukin 6 Family Cytokine)
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LIFR expression
21d
Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor. (PubMed, Cell Death Discov)
Finally, GC's high LIFR expression was associated with better clinical outcomes in patients. LIF treatment could thus represent a targeted anti-CSC strategy to fight against metastatic GC, and LIFR detection in primary tumours could constitute a potential new prognosis marker in this disease.
Journal • Cancer stem
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
25d
IFNT-induced IRF1 enhances bovine endometrial receptivity by transactivating LIFR. (PubMed, J Reprod Immunol)
Dual luciferase reporter assay verified that IRF1 could transactivate LIFR transcription by binding to its promoter. In conclusion, IFN-τ can induce IRF1 expression in bovine endometrial epithelial cells, and IRF1 upregulates LIFR expression by binding to LIFR promoter, contributing to the enhancement of bovine endometrial receptivity.
Journal
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CDH1 (Cadherin 1) • IRF1 (Interferon Regulatory Factor 1) • LIFR (LIF Receptor Subunit Alpha) • ITGAV (Integrin Subunit Alpha V) • HOXA10 (Homeobox A10) • ITGB3 (Integrin Subunit Beta 3) • LIF (LIF Interleukin 6 Family Cytokine)
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CDH1 expression • IRF1 expression • LIFR expression
5ms
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness. (PubMed, Cancer Biol Ther)
Additionally, our bioinformatic analysis reveals a signature of transcriptional regulation associated with FAM3C/LIFR interaction and identifies the TWIST1 transcription factor as a downstream effector that participates in the maintenance of LIFR expression. Finally, we characterize the effect of LIFR expression in cell-based experiments that demonstrate the promotion of invasion, migration, and self-renewal of breast cancer stem cells (BCSCs), consistent with previous studies linking LIFR expression to tumor initiation and metastasis in mammary epithelial cells.
Journal • Cancer stem
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LIFR (LIF Receptor Subunit Alpha) • TWIST1 (Twist Family BHLH Transcription Factor 1) • LIF (LIF Interleukin 6 Family Cytokine)
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LIFR expression • STAT3 overexpression
1year
Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma. (PubMed, Front Oncol)
Overexpression of LIFR suppressed the migration and invasion of UCEC cells in vitro. Our pan-cancer detection data provided a novel understanding of the roles of LIFR in oncogenesis.
Journal • Pan tumor
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
2years
Circ_0003159 upregulates LIFR expression through competitively binding to miR-221-3p/miR-222-3p to block gastric cancer development. (PubMed, J Mol Histol)
The tumorigenicity assay showed that circ_0003159 overexpression inhibited tumor growth in vivo. In conclusion, circ_0003159 inhibited GC development in vitro and in vivo by enriching the level of LIFR via direct binding to miR-221-3p/miR-222-3p.
Journal
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CASP3 (Caspase 3) • LIFR (LIF Receptor Subunit Alpha) • MIR221 (MicroRNA 221)
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LIFR expression
2years
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. (PubMed, Nat Commun)
Notably, an LCN2-neutralizing antibody enhances the ferroptosis-inducing and anticancer effects of sorafenib on HCC patient-derived xenograft tumors with low LIFR expression and high LCN2 expression. Thus, anti-LCN2 therapy is a promising way to improve liver cancer treatment by targeting ferroptosis.
Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
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sorafenib
over2years
HDAC inhibitors stimulate LIFR when it is repressed by hypoxia or PTHrP in breast cancer. (PubMed, J Bone Oncol)
In a second model of LIFR repression, in which parathyroid hormone-related protein (PTHrP) suppresses LIFR expression, we found that PTHrP binds to the distal LIFR promoter, and that PTHrP suppression of LIFR protein is similarly reversed by HDAC inhibitor treatment. Together, these data suggest that HDAC inhibitors stimulate LIFR regardless of the way it is repressed by the microenvironment.
Journal
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LIFR (LIF Receptor Subunit Alpha) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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LIFR expression
over2years
HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer. (PubMed, Oncogene)
Recent Phase II clinical trial data studying entinostat and azacitidine in metastatic breast cancer revealed that induction of several pro-dormancy genes post-treatment was associated with prolonged patient survival. Together, these findings suggest HDACi as a potential therapeutic avenue to promote dormancy, prevent recurrence, and improve patient outcomes in breast cancer.
Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
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azacitidine • Jingzhuda (entinostat)
almost3years
Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis. (PubMed, Dig Dis Sci)
Lidocaine might GC cell malignancy by modulating circ_ANO5/miR-21-5p/LIFR axis, highlighting a novel insight for GC treatment.
Journal
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MIR21 (MicroRNA 21) • LIFR (LIF Receptor Subunit Alpha) • ANO5 (Anoctamin 5)
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LIFR expression • miR-21 overexpression • miR-21 expression
almost3years
Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer. (PubMed, Mol Cancer Res)
These results indicate that the LIFR/STAT3 pathway may mediate either tumor promoting or tumor suppressive signaling pathways depending on the genetic background of tumor cells, and may play diverse roles within other cells in the tumor microenvironment. Implications: Mutant KRAS drives downregulation of the receptor for leukemia inhibitory factor, thereby allowing an increase in expression of the glucose transporter GLUT1 and increases in glycolysis and mitochondrial respiration.
Journal
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KRAS (KRAS proto-oncogene GTPase) • LIFR (LIF Receptor Subunit Alpha)
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KRAS mutation • LIFR expression
3years
Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression. (PubMed, Environ Toxicol)
circ_0001073 increased LIFR expression via miR-626 in lung cancer cells. In conclusion, circ_0001073 represses lung cancer progression via miR-626/LIFR axis, indicating the potential value of circ_0001073 in lung cancer treatment.
Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
over3years
[VIRTUAL] CLINICAL SIGNIFICANCE OF LEUKEMIA INHIBITORY FACTOR (LIF) AND ITS RECEPTORS IN PANCREATIC ADENOCARCINOMA (APCM 2020)
LIF was up-regulated and high LIF expression was associated with poor prognosis while LIFR was down-regulated and high LIFR expression was associated with favorable prognosis in pancreatic adenocarcinoma. LIF and LIFR might be therapeutic targets and prognostic markers for individual therapy of pancreatic adenocarcinoma.
Clinical
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KRAS (KRAS proto-oncogene GTPase) • STAT3 (Signal Transducer And Activator Of Transcription 3) • LIFR (LIF Receptor Subunit Alpha)
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KRAS G13 • LIFR expression • KRAS expression
over3years
Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway. (PubMed, Ann N Y Acad Sci)
Overall, the results demonstrate that LIF promotes the malignant biological behavior of GC cells through LIFR-Hippo-YAP signaling. LIF may therefore be a useful biomarker for GC.
Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
over3years
Prognostic value of leukemia inhibitory factor and its receptor in pancreatic adenocarcinoma. (PubMed, Future Oncol)
Eight cohorts containing 1278 cases with PAAD were identified and the analysis results suggested that LIF was highly expressed while LIFR was lowly expressed in PAAD tissues compared with adjacent or normal tissues. Kaplan-Meier plot curves and univariate and multivariate Cox proportional hazards regression analyses indicated high LIF expression was associated with shorter overall survival (adjusted hazard ratio = 1.641, 95% CI: 1.399-1.925, p < 0.001) whereas high LIFR expression was associated with longer overall survival (adjusted hazard ratio = 0.653, 95% CI: 0.517-0.826, p < 0.001).
Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
over3years
Novel Long Non-coding RNA lncAMPC Promotes Metastasis and Immunosuppression in Prostate Cancer by Stimulating LIF/LIFR Expression. (PubMed, Mol Ther)
High LIF/LIFR levels indicated shorter biochemical recurrence-free survival among patients who underwent radical prostatectomy. Therefore, the lncAMPC/LIF/LIFR axis plays a critical role in PCa metastasis and immunosuppression and may serve as a prognostic biomarker and potential therapeutic target.
Journal • PD(L)-1 Biomarker
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PD-L1 (Programmed death ligand 1) • JAK1 (Janus Kinase 1) • LIFR (LIF Receptor Subunit Alpha)
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LIFR expression
almost4years
Efficacy of Leukemia Inhibitory Factor as a Therapeutic for Permanent Large Vessel Stroke Differs among Aged Male and Female Rats. (PubMed, Brain Res)
These results demonstrated that low LIFR expression reduces the neuroprotective efficacy of LIF in aged rodents of both sexes. Furthermore, the ability of LIF to promote motor improvement is dependent upon sex in aged rodents.
Preclinical • Journal
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LIFR (LIF Receptor Subunit Alpha)
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LIFR expression