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    GENE:

    LIF (LIF Interleukin 6 Family Cytokine)

    i
    Other names: LIF, LIF Interleukin 6 Family Cytokine, HILDA, Leukemia Inhibitory Factor, CDF, DIA, Differentiation Inhibitory Activity, Cholinergic Differentiation Factor, Differentiation-Stimulating Factor, Hepatocyte-Stimulating Factor III, Differentiation-Inducing Factor, Melanoma-Derived LPL Inhibitor, Human Interleukin In DA Cells, D Factor, MLPLI, LIF, Interleukin 6 Family Cytokine, Emfilermin
    Associations

    News

    Trials
    3d
    Association of Increased Nasal Fluids-Serum Concordance of Protein Profile with Prognosis in Nasal Polyps. (PubMed, J Inflamm Res)
    Transcriptional (Twist1/NR2F2) and post-transcriptional (miRNA-mediated) regulatory mechanisms were implicated in LIFR-driven pathogenesis. Our study first investigated NF-serum proteomic concordance as a predictor of PR and demonstrated the potential of integrated multi-compartment analysis for predicting recurrence.
    Journal
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    LIFR (LIF Receptor Subunit Alpha) • CD31 (Platelet and endothelial cell adhesion molecule 1) • TWIST1 (Twist Family BHLH Transcription Factor 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • LIF (LIF Interleukin 6 Family Cytokine)
    7d
    A Synthesis of Novel Tetracyclic Azocino[4,3-b]Indole Framework: Combined Spectroscopic, DFT, Molecular Docking, and ADMET Analysis. (PubMed, Chem Biodivers)
    The interactions of I-VI against DNA gyrase of E. coli, CYP51 from Candida glabrata, and leukemia inhibitory factor were evaluated with molecular docking for foresight into the possible bioactivities. This comprehensive work hopefully to provide the structural, physical, and chemical properties, which would be important to optimizing the related properties of the molecular systems for biomedical purposes.
    Journal
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    LIF (LIF Interleukin 6 Family Cytokine)
    11d
    Systemic Loss of FKBPL Uncovers Diabetes-Dependent Pathways of Myocardial and Vascular Injury. (PubMed, Arterioscler Thromb Vasc Biol)
    FKBPL-based peptide mimetic, AD-01 (1 nM), in high-glucose conditions, upregulated endothelial vcam1 and glut1 mRNA expression, independent of miR-302b-5p. FKBPL plays an important role in glucose metabolism, endothelial function, angiogenesis, cardiac inflammation and function, and could be explored as a therapeutic target of cardiovascular disease both in nondiabetes and diabetes settings using precision medicine approach.
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    ICAM1 (Intercellular adhesion molecule 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • LCN2 (Lipocalin-2) • IL15 (Interleukin 15) • IL22 (Interleukin 22) • IL7 (Interleukin 7) • SIRT1 (Sirtuin 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CDH5 (Cadherin 5) • FKBP5 (FKBP Prolyl Isomerase 5) • MIR302B (MicroRNA 302b) • POSTN (Periostin) • SLC2A1 (Solute Carrier Family 2 Member 1) • LIF (LIF Interleukin 6 Family Cytokine)
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    Zanosar (streptozocin)
    18d
    Inflammatory profile associated with hyperglycemia in children with type 1 diabetes. (PubMed, J Diabetes Complications)
    A broad range of inflammatory mediators are correlated with HbA1c in children with T1D. These inflammatory changes precede development of T1D complications, suggesting that possible pathophysiologic involvement should be investigated.
    Journal
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    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL2 (Interleukin 2) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • MMP2 (Matrix metallopeptidase 2) • CCL2 (Chemokine (C-C motif) ligand 2) • IL18 (Interleukin 18) • CCL8 (C-C Motif Chemokine Ligand 8) • IL17A (Interleukin 17A) • IL23A (Interleukin 23 Subunit Alpha) • CCL27 (C-C Motif Chemokine Ligand 27) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • IL13 (Interleukin 13) • IL21 (Interleukin 21) • IL4 (Interleukin 4) • MMP1 (Matrix metallopeptidase 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • IL33 (Interleukin 33) • LIF (LIF Interleukin 6 Family Cytokine)
    25d
    Obesity Reduces Endometrial Receptivity by Downregulating the Ob-Rb/STAT-3 Signaling Pathway in Women and Female Mice. (PubMed, J Endocr Soc)
    Obesity-induced Ob-Rb/STAT-3 signaling dysfunction is a central mechanism impairing endometrial receptivity. Leptin resensitization via weight loss partially reverses these effects, suggesting potential therapies for targeting leptin resistance or Ob-Rb/STAT-3 signaling in obesity-related infertility.
    Preclinical • Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • LEP (Leptin) • LIF (LIF Interleukin 6 Family Cytokine)
    25d
    Deciphering the role of circulating inflammatory proteins in myocarditis: Novel strategies for targeted therapy. (PubMed, Int J Cardiol)
    Elevated circulating LIF levels may be causally linked to increased myocarditis risk, supporting its potential as both a predictive biomarker and a therapeutic target. These results provide a rationale for further experimental studies to clarify the context-dependent roles of LIF in myocardial inflammation and to evaluate LIF-directed interventions.
    Journal
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    IL10 (Interleukin 10) • LIF (LIF Interleukin 6 Family Cytokine)
    1m
    Mendelian randomization analysis of immune cell subsets and inflammatory cytokines in aplastic anaemia. (PubMed, Ann Hematol)
    This study established causal relationships between specific immune cell phenotypes, inflammatory cytokines, and AA. Importantly, LIF partially mediated the effects of immune cells on AA, suggesting the LIF-LIFR axis as a potential therapeutic target.
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    CD4 (CD4 Molecule) • IL7R (Interleukin 7 Receptor) • LIFR (LIF Receptor Subunit Alpha) • LIF (LIF Interleukin 6 Family Cytokine)
    1m
    LIFR antagonism reverses epithelial pro-CAF programs in pancreatic ductal adenocarcinoma. (PubMed, Biochem Pharmacol)
    Exposure of PDCA cell lines to LRI310 suppresses STAT3 activation and counteracts effects of LIF on proliferation and CAF-inducing transcriptional programs. Collectively, these findings identify LIF as an important epithelial driver of CAF-oriented transcriptional programs in PDAC and support the development of LIFR antagonism as a promising strategy to modulate the desmoplastic microenvironment.
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    IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • LIFR (LIF Receptor Subunit Alpha) • LIF (LIF Interleukin 6 Family Cytokine)
    1m
    Time-Resolved Oxidative Stress and Apoptosis in Murine Retina under Acute Hypobaric Hypoxia with Parallel Activation of the LIF-JAK-STAT3 Axis. (PubMed, Mol Neurobiol)
    LIF/LIFR protein accumulated from 2-72 h (48 h apex). These time-resolved data reveal progressive oedema with sustained oxidative burden and a LIF-JAK1-STAT3 activation peak, suggesting a therapeutic window in AHH-induced retinal injury.
    Preclinical • Journal
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    BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1) • TNFA (Tumor Necrosis Factor-Alpha) • JAK1 (Janus Kinase 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • LIFR (LIF Receptor Subunit Alpha) • LIF (LIF Interleukin 6 Family Cytokine)
    1m
    Novel Genetic Findings in Stuve-Wiedemann Syndrome: A Case Report and Review of Literature. (PubMed, Clin Case Rep)
    SWS is a rare autosomal recessive disorder characterized by autonomic dysfunction and bent-bone dysplasia due to pathogenic homozygous or compound heterozygous variants in the LIFR gene. Management is currently supportive, and further research is required to improve treatment and prognosis.
    Journal
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    LIFR (LIF Receptor Subunit Alpha) • CNTFR (Ciliary Neurotrophic Factor Receptor) • LIF (LIF Interleukin 6 Family Cytokine)
    2ms
    Bushen Huoxue recipe regulates endometrial epithelial ion channels to promote embryo implantation in controlled ovarian hyperstimulation mice. (PubMed, J Chin Med Assoc)
    BSHX may improve assisted reproductive technology pregnancy rates by regulating sex hormones and uterine fluid balance to prevent COH-induced endometrial damage.
    Preclinical • Journal
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    CFTR (CF Transmembrane Conductance Regulator) • LIF (LIF Interleukin 6 Family Cytokine)
    2ms
    Nogo-A-cleaved amino-terminal fragment but not Nogo-B regulates STAT3 activation. (PubMed, Biochem Biophys Res Commun)
    Importantly, LIF treatment promoted the generation of the Nogo-A N-terminal fragment in HEK293T cells. Taken together the NogoA-N-terminal fragment NogoA-213 but not Nogo-B plays a role in STAT3 activation.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • LIF (LIF Interleukin 6 Family Cytokine)