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    GENE:

    Let-7c (MicroRNA Let-7c)

    i
    Other names: Let-7c, MicroRNA Let-7c, Hsa-Let-7c-5p, Hsa-Let-7c, MIRLET7C, Hsa-Let-7-P1c, LET7C
    1d
    CD168 in lung adenocarcinoma: prognostic relevance, immune feature associations, and MAPK/ERK pathway enrichment. (PubMed, Med Oncol)
    Furthermore, Western blot analysis revealed that silencing CD168 decreased the phosphorylation levels of ERK and MEK, suggesting that CD168 promotes LUAD progression in association with MAPK/ERK signaling pathway activity. In summary, CD168 may promote LUAD progression by reshaping the immunosuppressive microenvironment and enhancing malignant behavior, establishing it as a prognostic biomarker and a potential therapeutic target, particularly for immunotherapy combinations.
    Journal • IO biomarker
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    CD68 (CD68 Molecule) • Let-7c (MicroRNA Let-7c) • CYTOR (Cytoskeleton Regulator RNA)
    29d
    A BDE-47/estrone mixture modulates macrophage immune responses and miRNA networks, impairs intestinal barrier integrity in vitro, and alters circulating miRNAs and tight junction expression in vivo. (PubMed, Ecotoxicol Environ Saf)
    Circulating miRNA profiling showed upregulation of inflammation-associated miRNAs (miR-21-5p, miR-150-5p, miR-142-3p, miR-363-3p), linked through bioinformatic analysis to immune dysregulation, intestinal cancer, and neurotoxicity. Overall, these results indicate that low-dose exposure to pollutant mixtures can induce subtle but biologically relevant immune and epithelial changes, emphasizing the importance of mixture-based approaches in environmental risk assessment.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • IL10 (Interleukin 10) • MIR21 (MicroRNA 21) • MIR142 (MicroRNA 142) • Let-7c (MicroRNA Let-7c) • MIR363 (MicroRNA 363) • MIR128 (MicroRNA 128) • MIR150 (MicroRNA 150) • MIR423 (MicroRNA 423) • OCLN (Occludin)
    2ms
    Comprehensive Transcriptome and miRNome Profiling in Metachronous Colorectal Liver Metastasis: Insight into the Prognostic and Molecular Subtypes. (PubMed, Lab Invest)
    The miRNA-mRNA interactions were validated using real-time PCR in independent patient cohorts. This study revealed a complex molecular landscape of mCLM within the hepatic microenvironment and novel miRNA-mRNA interactions with potential prognostic and therapeutic implications.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • MIR21 (MicroRNA 21) • MIR7 (MicroRNA 7) • Let-7c (MicroRNA Let-7c) • MIR106A (MicroRNA 106a) • MIR139 (MicroRNA 139) • MIR20B (MicroRNA 20b) • MIR320A (MicroRNA 320a) • MIR660 (MicroRNA 660) • MIR1304 (MicroRNA 1304) • MIR320B (MicroRNA 320b)
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    KRAS mutation
    2ms
    NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis. (PubMed, Cancer Gene Ther)
    In animal models and clinical tissues, NRAV expression correlates with disease progression and CSC marker accumulation. Our findings uncover a novel NRAV-let-7c-5p-LIN28B axis that links m6A modification to CSC maintenance in HCC, highlighting a potential therapeutic target for disrupting stemness pathways in liver cancer.
    Journal
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    Let-7c (MicroRNA Let-7c) • LIN28B (Lin-28 Homolog B)
    2ms
    Treadmill exercise ameliorates atherogenesis and vascular inflammation in ApoE-/- mice via circulating exosome-derived let-7c-5p. (PubMed, Sci Rep)
    Cellular experiments further corroborated the regulatory effect of let-7c-5p on Timp-3. Overall, these results suggest that exercise promotes Timp-3 expression by downregulating let-7c-5p carried by circulating exosomes, thereby mitigating atherogenesis and vascular inflammation in ApoE-/- mice.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MMP9 (Matrix metallopeptidase 9) • APOE (Apolipoprotein E) • Let-7c (MicroRNA Let-7c) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
    2ms
    Deciphering the let-7c-5p/RRM2 axis in lung adenocarcinoma: expression, prognosis, and immune landscape implications. (PubMed, Front Oncol)
    Our findings suggest that RRM2 is closely associated with the malignant progression of LUAD and may serve as a potential prognostic biomarker with clinical relevance. Furthermore, the let-7c-5p/RRM2 regulatory axis may play an important role in the development and progression of LUAD, representing a promising therapeutic target that warrants further in-depth investigation.
    Journal
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    RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • Let-7c (MicroRNA Let-7c)
    2ms
    A novel biochip-based liquid biopsy for extracellular vesicle RNA detection in prostate cancer. (PubMed, Cancer Biol Ther)
    Key markers such as miR-141, miR-375, and PCA3 showed strong diagnostic and risk stratification value in PCa. This non-invasive approach holds promise for improving early detection and clinical risk assessment.
    Journal • Liquid biopsy
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    Let-7c (MicroRNA Let-7c) • MIR141 (MicroRNA 141) • MIR375 (MicroRNA 375) • PCA3 (Prostate cancer associated 3)
    2ms
    Altered microRNA profiles and associated pathways in canine mammary adenocarcinoma. (PubMed, Sci Rep)
    Pathway enrichment linked these deregulated miRNAs to key oncogenic networks, particularly PI3K/AKT/mTOR, Wnt/β-catenin, and EMT regulation, demonstrating conserved molecular mechanisms shared with human BC and highlighting their potential as biomarkers in CMTs. These findings provide insights into the molecular mechanisms of CMT adenocarcinoma and suggest the potential of miRNA-based biomarkers for the diagnosis and treatment of CMTs.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • Let-7c (MicroRNA Let-7c) • MIR143 (MicroRNA 143) • MIR106B (MicroRNA 106b) • MIR10B (MicroRNA 10b) • MIR15A (MicroRNA 15a) • MIR191 (MicroRNA 191) • MIR205 (MicroRNA 205) • MIR26A1 (MicroRNA 26a-1) • MIR93 (MicroRNA 93)
    3ms
    The Long Non-Coding RNA SNHG16 Negatively Regulates Let-7 and Predicts Recurrence in Hepatocellular Carcinoma. (PubMed, J Hepatocell Carcinoma)
    Both bioinformatics analysis and clinical sample validation revealed that high SNHG16 expression in HCC tissues was associated with shorter disease-free survival (HR = 1.711, 95% CI: 1.144-2.559, p = 0.009), higher recurrence rates (p < 0.001), and shorter overall survival (HR = 1.837, 95% CI: 1.283-2.629, p = 0.001). SNHG16 negatively regulates let-7c and serves as a prognostic biomarker for HCC recurrence and survival.
    Journal
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    Let-7c (MicroRNA Let-7c) • SNHG16 (Small Nucleolar RNA Host Gene 16)
    4ms
    Explicating miRNA-mediated regulation of inflammatory pathways in COPD, MS, and lung cancer using explainable artificial intelligence: insights from peripheral blood profiles. (PubMed, Integr Biol (Camb))
    This study identifies miRNAs and their target genes as critical regulators of inflammation in COPD, MS, and lung cancer. Single-cell insights and pathway enrichment provide a comprehensive view of shared molecular mechanisms, contributing to biomarker discovery and therapeutic strategies for precision medicine in inflammatory diseases.
    Journal
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    IL6 (Interleukin 6) • CCL2 (Chemokine (C-C motif) ligand 2) • Let-7c (MicroRNA Let-7c) • MIR223 (MicroRNA 223) • MIR454 (MicroRNA 454) • ITGB3 (Integrin Subunit Beta 3)
    4ms
    The impact of the let-7 family on the pathophysiological mechanisms of traumatic brain injury: a systematic review. (PubMed, Front Neurol)
    Their regulatory roles in inflammation, metabolism, and neuroprotection suggest therapeutic promise. However, current evidence remains fragmented, and further mechanistic studies are necessary to validate their function in post-TBI recovery and to explore their utility as clinical biomarkers or treatment targets.
    Review • Journal
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    IL6 (Interleukin 6) • Let-7c (MicroRNA Let-7c)
    4ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)