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DRUG:

Lenocta (sodium stibogluconate)

i
Other names: VQD-001
Associations
Company:
VioQuest
Drug class:
Protein tyrosine phosphatase inhibitor
Associations
7ms
LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study (clinicaltrials.gov)
P2, N=52, Recruiting, Drugs for Neglected Diseases | Not yet recruiting --> Recruiting | Trial primary completion date: Sep 2025 --> Jun 2025
Enrollment open • Trial primary completion date
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Lenocta (sodium stibogluconate)
9ms
Effect of sodium stibogluconate in recruiting and awakening immune cells in the pleural fluid of pancreatic cancer: preparation for immunotherapy. (PubMed, Front Immunol)
Our study showed that the process of SSG fusion treatment of ascites and pleural effusion, the interaction between TandNK cells, MPs cells, monocytes and neutrophils was induced, and large numbers of genes were expressed, resulting in upregulation of immune response, which also approved that SSG is not only used as a protein tyrosine phosphatase inhibitor, but also it works as a protein tyrosine phosphatase inhibitor. It can also be used to regulate immune cell function, recruiting immune cells to the right place with the help of PD-1 or PD-L1 to fight cancer cells in ascites and pleural effusions in cancer patients.
Journal • Immune cell
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PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1)
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Lenocta (sodium stibogluconate)
11ms
Trial completion date • Trial primary completion date
|
Lenocta (sodium stibogluconate)
12ms
LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study (clinicaltrials.gov)
P2, N=52, Not yet recruiting, Drugs for Neglected Diseases | Trial completion date: Jan 2025 --> Jul 2025 | Initiation date: Sep 2023 --> Jan 2024 | Trial primary completion date: Jan 2025 --> Jul 2025
Trial completion date • Trial initiation date • Trial primary completion date
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Lenocta (sodium stibogluconate)
almost3years
Sodium stibogluconate and CD47-SIRPα blockade overcome resistance of anti-CD20-opsonized B cells to neutrophil killing. (PubMed, Blood Adv)
Anti-CD20 antibodies, like rituximab, are broadly used to treat B cell malignancies. The killing in the presence of SSG required both antibody opsonization of the target cells, as well as disruption of CD47-SIRPα interactions. These results provide a more detailed understanding of the role of neutrophil trogocytosis in antibody-mediated destruction of B cells and clues on how to further optimize antibody therapy of B cell malignancies.
Journal
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SIRPA (Signal Regulatory Protein Alpha)
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Rituxan (rituximab) • Lenocta (sodium stibogluconate)
over3years
Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations (clinicaltrials.gov)
P2, N=5, Recruiting, First Affiliated Hospital of Jinan University
New P2 trial
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TP53 (Tumor protein P53)
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TP53 mutation • TP53 K139N • TP53 R196* • TP53 R213
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Lenocta (sodium stibogluconate)