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BIOMARKER:
LDHB overexpression
i
Other names: LDHB, L-lactate dehydrogenase B chain, LDH heart subunit, LDH-H, Renal carcinoma antigen NY-REN-46, Testicular secretory protein Li 25, Epididymis secretory protein Li 281, Lactate dehydrogenase H chain, TRG-5, HEL-S-281
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Our investigations, which included metabolic and genetic pathway enrichment analyses, indicated that patients exhibiting heightened HBDH expression were characterized by distinct pathways related to energy metabolism and lymphoma progression. In conclusion, elevated HBDH levels were correlated with adverse survival and might serve as an independent parameter for evaluating patient outcomes.
2 months ago
Journal
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LDHA (Lactate dehydrogenase A) • LDHB (L-lactate dehydrogenase B chain)
Finally, we found that overexpression of LDHB suppressed HCC growth in immunocompetent but not in immunodeficient mice, suggesting that the host immune system was involved in the LDHB-medicated tumor suppression. Our findings indicate that DNMT3A-mediated epigenetic silencing of LDHB may contribute to HCC progression through remodeling the tumor immune microenvironment, and LDHB may become a potential prognostic biomarker and therapeutic target for HCC immunotherapy.
7 months ago
Journal • IO biomarker
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DNMT3A (DNA methyltransferase 1) • LDHB (L-lactate dehydrogenase B chain)
Knocking down LDHA and LDHB together fully suppressed lactate secretion and effectively suppressed the malignant phenotype of cells transformed by long-term MNNG exposure. Finally, we demonstrated that overexpression of LDHA and LDHB promotes the malignant transformation of GES-1 cells by enhancing the Warburg effect during long-term exposure to NOCs.
over 1 year ago
Journal
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LDHA (Lactate dehydrogenase A) • LDHB (L-lactate dehydrogenase B chain)
This study uncovered specific changes in the metabolic and proteomic profiling of breast cancer patients and identified a panel of 47 plasma metabolites, including sphingomyelins, glutamate, and cysteine could be potential diagnostic biomarkers for breast cancer.
While LDHB overexpression significantly suppressed the inhibitory effects of HYOU1 silencing on aerobic glycolysis, proliferation, migration and invasion in PTC cells. Taken together, our findings suggest that HYOU1 promotes glycolysis and malignant progression in PTC cells via upregulating LDHB expression, providing a potential target for developing novel anticancer agents.
over 3 years ago
Journal
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LDHB (L-lactate dehydrogenase B chain) • MIR375 (MicroRNA 375)