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LAVA-051
i
Other names: LAVA-051, humanized gamma-delta bsTCE, humanized gamma-delta bispecific T-cell engager (bsTCE) antibody
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Company:
LAVA Therap
Drug class:
γδ TCR modulator, CD1D inhibitor
Related drugs:
11ms
Trial of LAVA-051 in Patients With Relapsed/Refractory CLL, MM, or AML (clinicaltrials.gov)
P1/2, N=102, Active, not recruiting, Lava Therapeutics | Recruiting --> Active, not recruiting
Enrollment closed
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LAVA-051
over1year
Lava-051, a Novel Bispecific Gamma-Delta T-Cell Engager (Gammabody), in Relapsed/Refractory MM and CLL: Pharmacodynamic and Early Clinical Data (ASH 2022)
LAVA-051 has been well tolerated early in dose escalation with pharmacodynamics and early clinical signs reflective of its intended MoA. The differentiating importance of these pharmacodynamic parameters with any correlating preliminary antitumor activity will be further elucidated with continued dose escalation by the IV and SC route and in the determination of the RP2D and schedule.
Clinical data • PK/PD data • IO biomarker
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IL6 (Interleukin 6) • IL2RA (Interleukin 2 receptor, alpha) • CD69 (CD69 Molecule) • CD1D (CD1d Molecule)
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CD1D expression
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LAVA-051
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