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    GENE:

    LAMA1 (Laminin Subunit Alpha 1)

    i
    Other names: LAMA1, Laminin Subunit Alpha 1, LAMA, Laminin Subunit Alpha-1, S-Laminin Subunit Alpha, Laminin-3 Subunit Alpha, Laminin, Alpha 1, Laminin A Chain, S-LAM Alpha, Laminin-1 Subunit Alpha, S-LAM-Alpha, PTBHS
    Associations

    News

    Trials
    2ms
    LAMA1 Promotes Tumor-Associated Macrophages Polarization Towards the M2 Phenotype and Induces Colorectal Cancer. (PubMed, Appl Biochem Biotechnol)
    Overall, these findings highlight a central role for LAMA1 in regulating macrophage polarization through the EGFR/AKT/CREB signaling pathway. Consequently, this process contributes to immune suppression and promotes tumor progression.
    Journal
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    LAMA1 (Laminin Subunit Alpha 1)
    2ms
    Paeoniflorin promotes therapeutic senescence in melanoma through endoplasmic reticulum stress and the calpain1/ERK5/p27 axis. (PubMed, Phytomedicine)
    Paeoniflorin induces melanoma cell senescence through the ER stress/calpain1/ERK5/p27 signaling axis, suggesting its potential as a novel therapeutic strategy against SKCM.
    Journal
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    CDKN1B (Cyclin dependent kinase inhibitor 1B) • CAPN1 (Calpain 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • LAMA1 (Laminin Subunit Alpha 1)
    2ms
    LAMA1 derived from colorectal cancer promotes M2 polarization in macrophages via activation of the EGFR/AKT/CREB pathway. (PubMed, Cent Eur J Immunol)
    LAMA1 generated from CRC stimulated the EGFR/AKT/CREB signaling pathway in macrophages to induce M2 polarization of macrophages and eventually promote CRC cell proliferation, migration, and invasion, as well as to activate the EMT process and block CRC cell apoptosis. As a pro-carcinogenic factor released by CRC cells, LAMA1 affects the activation of the EGFR/AKT/CREB pathway in macrophages, causing M2 polarization and aggravating the malignant evolution of CRC.
    Journal
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    LAMA1 (Laminin Subunit Alpha 1)
    2ms
    Targeting the LINC01272-FUS signal axis inhibits the migration and invasion of testicular germ cell tumors. (PubMed, Cancer Cell Int)
    We identified the LINC01272-FUS axis as a critical regulatory pathway in TGCTs progression, providing mechanistic insights for developing liquid biopsy biomarkers and RNA-targeted therapies.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • VIM (Vimentin) • FUS (FUS RNA Binding Protein) • CDH2 (Cadherin 2) • LAMA1 (Laminin Subunit Alpha 1)
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    TMB-L
    4ms
    Systems Biology-Based Drug Repositioning Identifies Extracellular Matrix Module as a Therapeutic Target in Lung Squamous Cell Carcinoma. (PubMed, J Med Chem)
    In vitro and in vivo experiments validated two repositioned drugs, Fingolimod and Piperlongumine, both targeting ECM components, significantly inhibited LSCC cell growth, proliferation and migration at concentrations below 10 μM. These results provide compelling evidence for the power of systems biology to identify subtype-specific therapeutic vulnerabilities. Our findings highlight a promising framework for precision oncology and underscore the potential of ECM-targeted interventions in LSCC.
    Journal
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    LAMA1 (Laminin Subunit Alpha 1)
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    fingolimod
    over1year
    Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer. (PubMed, Int J Mol Sci)
    A significant fraction of BC/CRC patients with a family history of these tumors harbored deleterious germline variants in DNA repair genes. Our findings can lead to strategies to improve the diagnosis, genetic counseling, and treatment of patients and their relatives.
    Journal
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    MLH1 (MutL homolog 1) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • MUTYH (MutY homolog) • MAD1L1 (Mitotic Arrest Deficient 1 Like 1) • NOS3 (Nitric oxide synthase 3) • LAMA1 (Laminin Subunit Alpha 1) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    over1year
    Analysis of serum peptidome profiles of non-metastatic and metastatic feline mammary carcinoma using liquid chromatography-tandem mass spectrometry. (PubMed, BMC Vet Res)
    The presence of both pro- and anti-proliferative proteins was observed, potentially indicating a distinctive characteristic of NmFMC. Conversely, proteins associated with poor prognosis and metastasis were noted in the mFMC group.
    Journal • Metastases
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    BCL6 (B-cell CLL/lymphoma 6) • POU5F1 (POU Class 5 Homeobox 1) • LAMA1 (Laminin Subunit Alpha 1)
    almost2years
    Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosis. (PubMed, Neurogenetics)
    Some of these molecules: COL5A1/3, COL6A1, COL22/27A1, FBLN1/2, ITGA3/5, ITGB1 and LAMA1/B1 (p < 0.01); NCAN, HAS1, MMP2/9, TIMP1/2 and TGFB1 (p < 0.05) correlated with GBM patient survival. In conclusion, this study identified both established and novel ECM molecules regulating GBM angiogenesis, suggesting NCAN and COL27A1 are new potential prognostic biomarkers for GBM.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • TGFB1 (Transforming Growth Factor Beta 1) • MMP9 (Matrix metallopeptidase 9) • COL22A1 (Collagen Type XXII Alpha 1 Chain) • COL6A1 (Collagen Type VI Alpha 1 Chain) • VCAN (Versican) • COL4A1 (Collagen Type IV Alpha 1 Chain) • COL5A1 (Collagen Type V Alpha 1 Chain) • HAS1 (Hyaluronan Synthase 1) • ITGA3 (Integrin Subunit Alpha 3) • ITGB1 (Integrin Subunit Beta 1) • LAMA1 (Laminin Subunit Alpha 1) • LAMB1 (Laminin Subunit Beta 1) • LAMC1 (Laminin Subunit Gamma 1)
    over2years
    A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features. (PubMed, Sci Rep)
    Our advanced ARMS organotypic model mimics (1) the interactions cells-ECM, (2) the cell growth maintenance, and (3) the expression of proteins that characterize tumor expansion and aggressiveness. In the future, the perfusion-based model could be used with primary patient-derived cell subtypes to create a personalized ARMS chemotherapy screening system.
    Preclinical • Journal
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    MMP2 (Matrix metallopeptidase 2) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • LAMA1 (Laminin Subunit Alpha 1)
    over2years
    Microenvironment commits breast tumor ECs to dedifferentiation by micro-RNA-200-b-3p regulation and extracellular matrix remodeling. (PubMed, Front Cell Dev Biol)
    The gene expression profile confirms the EndMT phenotype of tumor-derived ECs and migratory properties acquisition. Moreover, it indicates the role of miR-200b-3p, that is, regulating EndMT in pathological ECs and silencing several angiogenic growth factors and their receptors by directly targeting their mRNA transcripts.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • SPP1 (Secreted Phosphoprotein 1) • MIR200B (MicroRNA 200b) • GAS6 (Growth arrest specific 6) • CD31 (Platelet and endothelial cell adhesion molecule 1) • COL6A3 (Collagen Type VI Alpha 3 Chain) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • LAMA1 (Laminin Subunit Alpha 1) • MIR200 (MicroRNA 200)
    almost3years
    Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population. (PubMed, J Oncol)
    The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.
    Journal
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    LAMA1 (Laminin Subunit Alpha 1)
    3years
    A novel risk model based on the correlation between the expression of basement membrane genes and immune infiltration to predict the invasiveness of pituitary adenomas. (PubMed, Front Endocrinol (Lausanne))
    Using a variety of bioinformatics methods, we developed a novel risk model to predict the probability of PAs invasion based on the correlation between 11 BM genes and immune infiltration. These findings may facilitate closer surveillance and early diagnosis to prevent or treat IPAs in patients and improve the clinical awareness of patients at high risk of IPAs.
    Journal
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    GPC3 (Glypican 3) • SDC4 (Syndecan 4) • THBS2 (Thrombospondin 2) • LAMA1 (Laminin Subunit Alpha 1)