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GENE:

KRT5 (Keratin 5)

News alerts, weekly reports and conference planners

A Practical Immunohistochemistry-Based Model for Predicting Pathologic Complete Response in Estrogen Receptor-Strong Positive and HER2-Negative Breast Cancer Running title: IHC-Based Prediction Model of pCR in ER-Positive HER2-Negative Breast Cancer. (PubMed, J Breast Cancer)

This IHC-based model predicts pCR and helps identify subgroups in which pCR is associated with meaningful survival benefit following NAC in ER-positive/HER2-negative breast cancers. High-scoring patients may benefit from NAC, while patients with low- or intermediate-scores may be better managed with surgery and endocrine therapy. This model may support personalized treatment decisions regarding NAC.

9 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • KRT5 (Keratin 5)

HER-2 positive • ER positive • HER-2 negative • EGFR positive • ER positive + HER-2 negative • HER-2 negative + ER positive

11d

Alterations in the transcriptional profile of genes in tumors as a prerequisite for personalization of treatment in breast cancer patients (PubMed, Arkh Patol)

Comparative mRNA expression analysis confirms that a short preoperative course of aromatase inhibitors induces a more potent and uniform molecular response, characterized by profound suppression of proliferation and complete inhibition of estrogen-dependent signaling. Tamoxifen therapy is also effective but results in less pronounced suppression of key targets and, crucially, may be accompanied by early activation of the MYC oncogene, a potential marker for resistance development.

11 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor) • PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • FGFR4 (Fibroblast growth factor receptor 4) • BIRC5 (Baculoviral IAP repeat containing 5) • TYMS (Thymidylate Synthetase) • AURKA (Aurora kinase A) • FOXA1 (Forkhead Box A1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • BAG1 (BAG Cochaperone 1) • EMSY (EMSY Transcriptional Repressor BRCA2 Interacting) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5) • MMP11 (Matrix Metallopeptidase 11) • MYBL2 (MYB Proto-Oncogene Like 2) • SFRP1 (Secreted frizzled related protein 1) • TMEM45B (Transmembrane Protein 45B) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • SCGB2A2 (Secretoglobin Family 2A Member 2) • ZNF703 (Zinc Finger Protein 703)

HER-2 negative • HER-2 expression

tamoxifen • letrozole • anastrozole

20d

Integrative transcriptomic and structural modeling reveal CASP1, TLR3, PYCARD, and CD274 as immune-modulatory drivers in breast cancer. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)

Structural characterization identified nine high-impact nsSNPs (ΔΔG < - 1.7 kcal/mol), particularly in TLR3 (L104N, L381P, L77P) and CD274 (W57S, C155S, G159D, Y112N), indicating potential disruption of receptor stability, immune checkpoint interactions, and inflammasome regulation. This integrative multi-omics and structural pharmacogenomics framework reveals a robust four-gene signature (CASP1, TLR3, PYCARD, CD274) that links necroptosis, ferroptosis, and immune modulation in BRCA, providing promising avenues for precision oncology and therapeutic target development.

20 days ago

Journal • BRCA Biomarker

PD-L1 (Programmed death ligand 1) • BRCA (Breast cancer early onset) • TLR3 (Toll Like Receptor 3) • KRT5 (Keratin 5) • MAP1B (Microtubule Associated Protein 1B) • PYCARD (PYD And CARD Domain Containing) • CASP1 (Caspase 1)

26d

Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Tumor-Infiltrating Lymphocytes (TILs), for Patients with Triple-Negative Breast Cancer. (PubMed, Cancer Invest)

Patients with elevated tumor-infiltrating lymphocytes (TILs) and a NLR less than 3 had prolonged survival. NLR is a cost-effective and reliable tool that can be exploited in a wide number of scenarios during daily clinical practice.

26 days ago

Journal • Tumor-infiltrating lymphocyte

KRT5 (Keratin 5)

30d

Oncogene c-Myc Regulates Upper Respiratory Epithelial Repair for Host Immunity During Acute Influenza Infection. (PubMed, bioRxiv)

Basal-specific Myc deletion preserved viral replication and clearance but blunted injury-induced proliferation, skewed lineage differentiation, and impaired CD8 + NKT cell recruitment. These findings define a coordinated epithelial-immune program governing post-IAV mucosal restoration and offer mechanistic insight into persistent upper airway sequelae.

30 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD8 (cluster of differentiation 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • KRT5 (Keratin 5)

2ms

Angiomatoid Spindle Cell Thymomas (WHO Type A): An Unusual Histological Subtype That Can Mimic a True Vascular Neoplasm. (PubMed, Int J Surg Pathol)

Clinically, eight patients are alive without recurrence, while two were lost to follow-up. The histopathological features of these spindle cell thymomas represent an unusual subtype that can mimic primary vascular neoplasms, which may require different treatment and have varied outcomes.

2 months ago

Journal

CD34 (CD34 molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • TP63 (Tumor protein 63) • KRT5 (Keratin 5) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)

2ms

Clinicopathologic and Molecular Analyses of 2 Basomelanocytic Tumors and Literature Review. (PubMed, Am J Dermatopathol)

CDKN2A and PCTH1 mutations, frequently detected in melanoma and basal cell carcinoma, respectively, were detected in the second case. The presence of 2 components with distinct immunoprofile yet with some common genetic aberration suggests that basomelanocytic tumors may arise from a common progenitor.

2 months ago

Journal

NRAS (Neuroblastoma RAS viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • KDR (Kinase insert domain receptor) • SOX10 (SRY-Box 10) • KRT17 (Keratin 17) • MLANA (Melan-A) • TP63 (Tumor protein 63) • KRT5 (Keratin 5) • MITF (Melanocyte Inducing Transcription Factor)

2ms

Understanding Low-Grade Fibromatosis-Like Metaplastic Breast Carcinoma, a Tertiary Care Center Experience: Case Series and Review of Literature. (PubMed, Int J Surg Pathol)

Details of initial treatment were available in 9 patients, of which 3 developed metastases. Low-grade fibromatosis-like metaplastic breast carcinoma is a rare and distinct subtype of metaplastic breast cancer with unique histological features and heterogeneity in morphology, posing diagnostic challenges and should be diagnosed after meticulous clinicopathological evaluation, comprehensive sampling and extensive immunohistochemistry panel.

2 months ago

Journal

TP63 (Tumor protein 63) • KRT5 (Keratin 5)

3ms

Establishment and Characterization of a New Immortalized Human Adenomyosis Epithelial-Like Cell Line, tAEC21†. (PubMed, Biol Reprod)

In both 2D monolayer and 3D culture, tAEC21 cells responded to 17β-estradiol (E2) but did not respond to progesterone (P4), consistent with the expression of estrogen (ESR1) and progesterone (PGR) receptors. This new epithelial-like, adenomyosis-derived cell line, tAEC21, will be an impactful, biologically plausible research resource.

3 months ago

Preclinical • Journal

ER (Estrogen receptor) • TERT (Telomerase Reverse Transcriptase) • IL6 (Interleukin 6) • MUC1 (Mucin 1) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CCL2 (Chemokine (C-C motif) ligand 2) • MME (Membrane Metalloendopeptidase) • CDH2 (Cadherin 2) • KRT5 (Keratin 5)

3ms

Intraductal Papilloma Originating From Ectopic Breast Tissue Within a Sentinel Lymph Node Can Mimic Metastatic Carcinoma: A Case Report. (PubMed, Int J Surg Pathol)

Immunohistochemical analysis confirmed the diagnosis of ectopic intraductal papilloma, demonstrating positive staining for estrogen receptor (ER), progesterone receptor (PR), GATA3, and p63, with heterogeneous expression of ER, PR, and KRT5/6. Although it is extremely rare, this lesion highlights the importance of considering this phenomenon in differential diagnoses, as benign proliferative changes in ectopic breast tissue can mimic malignancy, necessitating careful histopathological and immunohistochemical evaluation.

3 months ago

Journal

ER (Estrogen receptor) • PGR (Progesterone receptor) • TP63 (Tumor protein 63) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5)

3ms

Construction of a Novel 3D Urinary Bladder Mucosa Model and Its Application in Toxicity Assessment of Arsenicals. (PubMed, Toxics)

Exposure to iAsIII and DMAV resulted in increased urothelial necrosis, increased γ-H2AX-positive cells, and reduced P63-positive cells, all in a dose-response manner. These findings affirm that this novel 3D-UBMM resembles the human bladder epithelium and offers a practical in vitro model for evaluating bladder toxicants and carcinogens, identifying mechanisms of carcinogenesis, and supporting hazard identification and risk assessment.

3 months ago

Journal

TP63 (Tumor protein 63) • KRT5 (Keratin 5) • UPK1B (Uroplakin 1B)

4ms

Primary Localized Peritoneal Malignant Mesothelioma Involving the Stomach and Transverse Colon: A Case Report. (PubMed, Korean J Gastroenterol)

In select cases, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy has shown promise. This case highlights the importance of considering PMM in the differential diagnosis of abdominal tumors and pursuing complete resection whenever feasible.

4 months ago

Journal

WT1 (WT1 Transcription Factor) • KRT5 (Keratin 5)