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GENE:

KRT5 (Keratin 5)

News alerts, weekly reports and conference planners

13d

Approach and nomenclature problems of extracutaneous basaloid neoplasias of visceral organs with three cases of basaloid carcinoma described for the first time in the urinary bladder. (PubMed, Histol Histopathol)

These show different patterns and variants, and have different nomenclature depending on the histological diversity/embryological development of the organ in which they are localized. We also noticed that adenoid cystic carcinoma and basaloid carcinoma have similar histology and are transitional to each other in many organs, necessitating a common nomenclature.

13 days ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • KRT7 (Keratin-7) • TP63 (Tumor protein 63) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5) • PLIN2 (Perilipin)

22d

Syringomatous Tumor Originating From an Axillary Supernumerary Mammary Tissue: First Report of an Axillary Tumor Case. (PubMed, Am J Dermatopathol)

Histopathologically, syringomatous tumor may resemble cutaneous adnexal tumors, particularly syringoma and microcystic adnexal carcinoma, and breast carcinomas. However, in addition to the clinical appearance and location, the presence of a peripheral myoepithelial lining and immunoexpression of SOX10 and c-kit may help exclude these entities.

22 days ago

Journal

ER (Estrogen receptor) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • SOX10 (SRY-Box 10) • KRT19 (Keratin 19) • TP63 (Tumor protein 63) • KRT5 (Keratin 5)

KIT expression

Evaluation of serum Cytokeratin 5 and p63 as non-invasive biomarkers for the diagnosis and staging of cervical cancer: a case-control study. (PubMed, Clin Transl Oncol)

Serum CK5 and p63 had an excellent diagnostic efficiency for cervical cancer and correlated with disease progression, positioning them as promising non-invasive biomarkers for diagnosis and staging.

1 month ago

Journal

TP63 (Tumor protein 63) • KRT5 (Keratin 5)

Enriched NKX2-1 Mutations in Bronchiolar Adenoma Variants: Evidence for Malignant Transformation or an Indolent Entity. (PubMed, Curr Med Sci)

These findings underscore the histopathological and genetic characteristics of BA and its variants, suggesting that monolayered BA-like lesions have the potential to develop into lung adenocarcinoma. In the future, more cases should be recruited to further explore the malignant transformation of this specific entity via the multidimensional spectrum.

1 month ago

Journal

NKX2-1 (NK2 Homeobox 1) • KRT5 (Keratin 5)

Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma. (PubMed, bioRxiv)

KRT5⁺ cells form cancer organoids over successive passages, are tumorigenic in serial dilution xenograft assays, and are resistant to the antineoplastic agents, doxorubicin and cisplatin. Together, these findings support a model in which HGSC contains two hierarchically related cell populations: KRT5⁺, OPN-responsive CPCs and KRT5⁻, non-tumorigenic cells that form a niche producing OPN. Targeting pathways that sustain both stem-like tumor cells and their supportive niche may enable reduced dosing of highly toxic chemotherapeutic agents while enhancing therapeutic efficacy in HGSC.

1 month ago

Journal

SPP1 (Secreted Phosphoprotein 1) • KRT5 (Keratin 5)

cisplatin • doxorubicin hydrochloride

2ms

A Practical Immunohistochemistry-Based Model for Predicting Pathologic Complete Response in Estrogen Receptor-Strong Positive and HER2-Negative Breast Cancer Running title: IHC-Based Prediction Model of pCR in ER-Positive HER2-Negative Breast Cancer. (PubMed, J Breast Cancer)

This IHC-based model predicts pCR and helps identify subgroups in which pCR is associated with meaningful survival benefit following NAC in ER-positive/HER2-negative breast cancers. High-scoring patients may benefit from NAC, while patients with low- or intermediate-scores may be better managed with surgery and endocrine therapy. This model may support personalized treatment decisions regarding NAC.

2 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • KRT5 (Keratin 5)

HER-2 positive • ER positive • HER-2 negative • EGFR positive • ER positive + HER-2 negative • HER-2 negative + ER positive

2ms

Alterations in the transcriptional profile of genes in tumors as a prerequisite for personalization of treatment in breast cancer patients (PubMed, Arkh Patol)

Comparative mRNA expression analysis confirms that a short preoperative course of aromatase inhibitors induces a more potent and uniform molecular response, characterized by profound suppression of proliferation and complete inhibition of estrogen-dependent signaling. Tamoxifen therapy is also effective but results in less pronounced suppression of key targets and, crucially, may be accompanied by early activation of the MYC oncogene, a potential marker for resistance development.

2 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor) • PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • FGFR4 (Fibroblast growth factor receptor 4) • BIRC5 (Baculoviral IAP repeat containing 5) • TYMS (Thymidylate Synthetase) • AURKA (Aurora kinase A) • FOXA1 (Forkhead Box A1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • BAG1 (BAG Cochaperone 1) • EMSY (EMSY Transcriptional Repressor BRCA2 Interacting) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5) • MMP11 (Matrix Metallopeptidase 11) • MYBL2 (MYB Proto-Oncogene Like 2) • SFRP1 (Secreted frizzled related protein 1) • TMEM45B (Transmembrane Protein 45B) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • SCGB2A2 (Secretoglobin Family 2A Member 2) • ZNF703 (Zinc Finger Protein 703)

HER-2 negative • HER-2 expression

tamoxifen • letrozole • anastrozole

2ms

Integrative transcriptomic and structural modeling reveal CASP1, TLR3, PYCARD, and CD274 as immune-modulatory drivers in breast cancer. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)

Structural characterization identified nine high-impact nsSNPs (ΔΔG < - 1.7 kcal/mol), particularly in TLR3 (L104N, L381P, L77P) and CD274 (W57S, C155S, G159D, Y112N), indicating potential disruption of receptor stability, immune checkpoint interactions, and inflammasome regulation. This integrative multi-omics and structural pharmacogenomics framework reveals a robust four-gene signature (CASP1, TLR3, PYCARD, CD274) that links necroptosis, ferroptosis, and immune modulation in BRCA, providing promising avenues for precision oncology and therapeutic target development.

2 months ago

Journal • BRCA Biomarker

PD-L1 (Programmed death ligand 1) • BRCA (Breast cancer early onset) • TLR3 (Toll Like Receptor 3) • KRT5 (Keratin 5) • MAP1B (Microtubule Associated Protein 1B) • PYCARD (PYD And CARD Domain Containing) • CASP1 (Caspase 1)

2ms

Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Tumor-Infiltrating Lymphocytes (TILs), for Patients with Triple-Negative Breast Cancer. (PubMed, Cancer Invest)

Patients with elevated tumor-infiltrating lymphocytes (TILs) and a NLR less than 3 had prolonged survival. NLR is a cost-effective and reliable tool that can be exploited in a wide number of scenarios during daily clinical practice.

2 months ago

Journal • Tumor-infiltrating lymphocyte

KRT5 (Keratin 5)

3ms

Oncogene c-Myc Regulates Upper Respiratory Epithelial Repair for Host Immunity During Acute Influenza Infection. (PubMed, bioRxiv)

Basal-specific Myc deletion preserved viral replication and clearance but blunted injury-induced proliferation, skewed lineage differentiation, and impaired CD8 + NKT cell recruitment. These findings define a coordinated epithelial-immune program governing post-IAV mucosal restoration and offer mechanistic insight into persistent upper airway sequelae.

3 months ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD8 (cluster of differentiation 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • KRT5 (Keratin 5)

3ms

Angiomatoid Spindle Cell Thymomas (WHO Type A): An Unusual Histological Subtype That Can Mimic a True Vascular Neoplasm. (PubMed, Int J Surg Pathol)

Clinically, eight patients are alive without recurrence, while two were lost to follow-up. The histopathological features of these spindle cell thymomas represent an unusual subtype that can mimic primary vascular neoplasms, which may require different treatment and have varied outcomes.

3 months ago

Journal

CD34 (CD34 molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • TP63 (Tumor protein 63) • KRT5 (Keratin 5) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)

3ms

Clinicopathologic and Molecular Analyses of 2 Basomelanocytic Tumors and Literature Review. (PubMed, Am J Dermatopathol)

CDKN2A and PCTH1 mutations, frequently detected in melanoma and basal cell carcinoma, respectively, were detected in the second case. The presence of 2 components with distinct immunoprofile yet with some common genetic aberration suggests that basomelanocytic tumors may arise from a common progenitor.

3 months ago

Journal

NRAS (Neuroblastoma RAS viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • KDR (Kinase insert domain receptor) • SOX10 (SRY-Box 10) • KRT17 (Keratin 17) • MLANA (Melan-A) • TP63 (Tumor protein 63) • KRT5 (Keratin 5) • MITF (Melanocyte Inducing Transcription Factor)