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    GENE:

    KRT14 (Keratin 14)

    i
    Other names: EBS3, EBS4, KRT14, Keratin 14
    4d
    Integrative analysis of polyamine-associated genes reveals a prognostic and immunological signature in esophageal squamous cell carcinoma. (PubMed, Discov Oncol)
    Drug sensitivity analysis based on oncoPredict revealed compounds with differential efficacy between risk groups, and the model also predicted response to PD-1 blockade in an external immunotherapy cohort. In summary, polyamine metabolism is closely linked to the immune microenvironment and prognosis of ESCA, providing a potential biomarker for patient stratification and treatment optimization.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • SQSTM1 (Sequestosome 1) • LYPD3 (LY6/PLAUR Domain Containing 3) • KRT14 (Keratin 14) • MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) • RUNX3 (RUNX Family Transcription Factor 3) • CXCL14 (C-X-C Motif Chemokine Ligand 14)
    12d
    GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER+ breast cancer: causal insights and prognostic implications. (PubMed, Transl Cancer Res)
    GNAL regulates the spatiotemporal immune remodeling of ER+ breast cancer via calcium signaling and stem-like cell differentiation. The multi-omics risk model offers clinical prognostic value and highlights GNAL as a potential target for precision immunotherapy.
    Journal • IO biomarker
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    ER (Estrogen receptor) • CD8 (cluster of differentiation 8) • CD74 (CD74 Molecule) • CD24 (CD24 Molecule) • KRT14 (Keratin 14)
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    ER positive
    14d
    RNAseq-based meta-analyses revealed tumor suppressor-inducer fusion events in liver, oral, and ovarian cancer in the Indian population: a cancer cell surviving mechanism. (PubMed, Nucleosides Nucleotides Nucleic Acids)
    WWOX2 serves as a tumor suppressor, whereas FUT1 functions as a promoter of malignancy. The interplay between tumor inducers and suppressors may serve as a survival mechanism for cancer cells, a subject that has received limited research attention.
    Journal • IO biomarker
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    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • CD38 (CD38 Molecule) • RANBP2 (RAN Binding Protein 2) • ERG (ETS Transcription Factor ERG) • S100A9 (S100 Calcium Binding Protein A9) • TMPRSS2 (Transmembrane serine protease 2) • KRT14 (Keratin 14) • AMBRA1 (Autophagy And Beclin 1 Regulator 1) • GABRP (Gamma-Aminobutyric Acid Type A Receptor Subunit Pi) • RNASE1 (Ribonuclease A Family Member 1) • WWOX (WW Domain Containing Oxidoreductase) • CBX3 (Chromobox 3)
    |
    BCR-ABL1 fusion • TMPRSS2-ERG fusion
    24d
    Identification of diagnostic and prognostic biomarkers in lung adenocarcinoma through integrated bioinformatics analysis and real time PCR validation. (PubMed, Sci Rep)
    Bioinformatics-identified genes are potential markers for early lung adenocarcinoma detection and management. RT-PCR validation shows AI's effectiveness in identifying biomarkers, enabling prompt treatment to halt disease progression.
    Journal
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    CD31 (Platelet and endothelial cell adhesion molecule 1) • KRT14 (Keratin 14) • CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
    1m
    Single-Cell Regulatory Network Analysis Identifies Adjunctive Drug Candidates in Early Risankizumab-Treated Psoriasis. (PubMed, Curr Pharm Des)
    These findings offer preliminary clues for future risankizumab-based combination strategies in psoriasis.
    Journal
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    CD4 (CD4 Molecule) • S100A8 (S100 Calcium Binding Protein A8) • S100A9 (S100 Calcium Binding Protein A9) • ELF3 (E74 Like ETS Transcription Factor 3) • KRT14 (Keratin 14) • MAFB (MAF BZIP Transcription Factor B) • KRT6A (Keratin 6A) • NFIC (Nuclear Factor I C) • SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1)
    |
    Jingzhuda (entinostat) • simvastatin
    2ms
    Cytoskeletal protein KRT14 governs cisplatin resistance by modulating eIF4H-dependent ACOX2 translation and lipid metabolism in bladder cancer. (PubMed, Cell Death Dis)
    Collectively, our findings reveal that KRT14 contributes to chemoresistance in BLCA not only via its structural roles but also by directly regulating translational machinery through eIF4H, leading to upregulation of the metabolic enzyme ACOX2. The newly defined KRT14-eIF4H-ACOX2 axis orchestrates lipid metabolic reprogramming and cell survival, underscoring the KRT14-eIF4H interface as a promising therapeutic target for overcoming cisplatin resistance in BLCA.
    Journal
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    KRT14 (Keratin 14) • EIF4G1 (Eukaryotic translation initiation factor 4 gamma, 1) • EIF4H (Eukaryotic Translation Initiation Factor 4H)
    |
    cisplatin
    2ms
    Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer. (PubMed, J Transl Med)
    PIE represents a clinically relevant, transcriptome-based predictive model for evaluating the benefit of ICI treatment in advanced NSCLC. With further prospective validation, PIE may facilitate personalized patient selection and guide the development of novel strategies to overcome primary resistance.
    Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IL7R (Interleukin 7 Receptor) • NCAM1 (Neural cell adhesion molecule 1) • KRT14 (Keratin 14) • SLC31A2 (Solute Carrier Family 31 Member 2) • SLC4A1 (Solute Carrier Family 4 Member 1)
    3ms
    Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11. (PubMed, bioRxiv)
    105B decreased levels of BET-regulated gene products c-Myc, RUNX2, and KRT14; however, improvements are still necessary to affect selective cytotoxicity. This work reports the first example of a PROTAC recruiting a tissue-specific E3 ligase for cancer-restricted degradation of BET proteins and highlights the need for further development of MAGEA11-recruiting degraders.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CRBN (Cereblon) • VHL (von Hippel-Lindau tumor suppressor) • BRD4 (Bromodomain Containing 4) • KRT14 (Keratin 14) • MAGEA1 (MAGE Family Member A1) • RUNX2 (RUNX Family Transcription Factor 2)
    4ms
    Single-cell RNA sequencing identifies potential critical prognostic biomarkers in bladder carcinoma. (PubMed, Sci Rep)
    Furthermore, IGFBP5, KRT14 and SERPINF1 were found to be linked to poor survival outcomes in BC, with their expression levels notably elevated in BC cell lines compared to a normal bladder cell line. This study identified potential prognostic marker genes for BC, offering valuable insights into the prediction of patient survival outcomes.
    Journal
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    IL17A (Interleukin 17A) • KRT14 (Keratin 14) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5)
    5ms
    Inverted papilloma with Civatte/colloid body-like eosinophilic structures, accumulated with Keratins 14-, 6a-, 5-, and 4-like proteins in an oriental turtle dove (Streptopelia orientalis). (PubMed, J Vet Med Sci)
    Immunohistochemistry confirmed strong reactivity of Keratin 14 in the basal layers of the tumor. This case of cutaneous inverted papilloma was distinguished by unique Civatte/colloid body-like structures and the accumulation of several keratins.
    Journal
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    KRT14 (Keratin 14)
    6ms
    Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. (PubMed, Front Oncol)
    We identified some differentially expressed genes relevant to oncogenic signaling and immunosuppressive tumor-associated macrophages. These findings provide novel insights into factors affecting prognosis in patients with residual disease after NAC for early-stage TNBC.
    Journal
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    ACTA2 (Actin Alpha 2 Smooth Muscle) • S100A9 (S100 Calcium Binding Protein A9) • CHI3L1 (Chitinase 3-like 1) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • KRT14 (Keratin 14) • COL3A1 (Collagen Type III Alpha 1 Chain) • IFI27 (Interferon Alpha Inducible Protein 27) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • MMP7 (Matrix metallopeptidase 7) • MYLK (Myosin Light Chain Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) • SERPINA3 (Serpin Family A Member 3) • TPM2 (Tropomyosin 2) • RPL22 (Ribosomal Protein L22)
    6ms
    MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells. (PubMed, bioRxiv)
    Mechanical properties of breast epithelial cells reflect biologic aging and cancer susceptibility. Mechano-RISQ offers a new approach for identifying individuals at elevated risk, especially among average-risk populations, and may complement existing risk models by incorporating biophysical measures of epithelial aging.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • KRT14 (Keratin 14)