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    GENE:

    KNOP1 (Lysine Rich Nucleolar Protein 1)

    i
    Other names: KNOP1, Lysine Rich Nucleolar Protein 1, FAM191A, TSG118, 101F10.1, C16orf88, Family With Sequence Similarity 191, Member A, Testis-Specific Gene 118 Protein, Lysine-Rich Nucleolar Protein 1, Chromosome 16 Open Reading Frame 88, Testis-Specific Gene 118, Protein C16orf88, Protein FAM191A
    Associations

    News

    Trials
    7ms
    KNOP1 interacts with NMNAT1 to govern ferroptosis and tumor growth in breast cancer via regulating FoxO1-dependent GPX4 transcription. (PubMed, Cell Signal)
    Importantly, NMNAT1 knockdown disrupted this regulatory axis by inducing FoxO1 nuclear export and subsequent GPX4 downregulation. Our findings establish that the KNOP1/NMNAT1 complex promotes BRCA progression through NAD+-dependent FoxO1/GPX4 signaling to inhibit ferroptosis, suggesting this axis as a novel therapeutic target for BRCA treatment strategies aimed at modulating iron-dependent cell death pathways.
    Journal • BRCA Biomarker
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    BRCA (Breast cancer early onset) • GPX4 (Glutathione Peroxidase 4) • KNOP1 (Lysine Rich Nucleolar Protein 1)
    over2years
    Identification of KNOP1 as a prognostic marker in hepatocellular carcinoma. (PubMed, Transl Cancer Res)
    KNOP1 overexpression is associated with poor HCC prognosis and increased proportions of immune cell infiltration and checkpoints. KNOP1 is a potential biomarker for evaluating HCC prognosis.
    Journal
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    KNOP1 (Lysine Rich Nucleolar Protein 1)