News - KMT2D mutation

Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. (PubMed, Proc Natl Acad Sci U S A)

However, combinations of copanlisib/afatinib and copanlisib/elimusertib were significantly more effective in controlling NETc tumor growth. These findings define the genetic landscape of NETc and suggest that a large subset of these highly lethal malignancies might benefit from existing targeted therapies.

4 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • KMT2D (Lysine Methyltransferase 2D) • NOTCH2 (Notch 2) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • MBD4 (Methyl-CpG Binding Domain 4, DNA Glycosylase) • PVT1 (Pvt1 Oncogene) • RPL10 (Ribosomal Protein L10)

KRAS mutation • PIK3CA mutation • ARID1A mutation • KMT2D mutation

Gilotrif (afatinib) • Aliqopa (copanlisib) • elimusertib (BAY 1895344)

12d

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. (PubMed, Nat Commun)

Their combined deficiency preferentially impairs activation of immune synapse-responsive super-enhancers, pointing to a particular dependency for both co-activators at these specialized regulatory elements. Together, our data provide an example where chromatin modifier mutations cooperatively shape and induce an immune-evasive microenvironment to facilitate lymphomagenesis.

12 days ago

Journal

CD8 (cluster of differentiation 8) • KMT2D (Lysine Methyltransferase 2D) • CREBBP (CREB binding protein)

KMT2D mutation

Comprehensive genomic profiling to identify actionable alterations for breast cancer brain metastases in the Chinese population. (PubMed, ESMO Open)

TMB and TILs were relatively low in BCBMs. Comparable consistency in actionable GAs was identified between BCBMs and matched PTs/ECMs. It was, therefore, logical to carry out genomic testing for BCBMs to identify potential new therapeutic targets when BCBM specimens were available, as âˆ¼31% of samples carried additional actionable GAs.

1 month ago

Journal • Tumor mutational burden • BRCA Biomarker

HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • FGFR1 (Fibroblast growth factor receptor 1) • CCND1 (Cyclin D1) • FGF19 (Fibroblast growth factor 19) • KMT2D (Lysine Methyltransferase 2D) • FGF3 (Fibroblast growth factor 3) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • RAD21 (RAD21 Cohesin Complex Component)

TP53 mutation • TMB-H • PIK3CA mutation • KMT2D mutation

FoundationOne® CDx

2ms

Genomic profiles and their relationships with clinical characteristics and immune features in cervical cancer. (PubMed, Transl Oncol)

This study offers insights into the mutation characteristics of cervical cancer patients and identifies potential therapeutic.

2 months ago

Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker

TMB (Tumor Mutational Burden) • NOTCH1 (Notch 1) • PD-1 (Programmed cell death 1) • KMT2D (Lysine Methyltransferase 2D) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • BARD1 (BRCA1 Associated RING Domain 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • CEP290 (Centrosomal Protein 290) • SLX4 (SLX4 Structure-Specific Endonuclease Subunit)

TMB-L • KMT2D mutation • HLA-A*03 • BARD1 mutation

2ms

Mutational patterns in therapy-related acute lymphoblastic leukemia subgroups: one step closer to unveiling the genetic odyssey. (PubMed, Leuk Lymphoma)

Outcome was particularly poor in Ph + trALL compared to Ph+ de novo ALL, which seemed to be mitigated by allogeneic stem cell transplantation. Our findings further define trALL as a distinct entity but highlight the need for further molecular genome sequencing of somatic and germline variants to advance our understanding of trALL.

2 months ago

Journal

KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • DNMT3A (DNA methyltransferase 1) • KMT2A (Lysine Methyltransferase 2A) • KMT2D (Lysine Methyltransferase 2D)

TP53 mutation • KRAS mutation • DNMT3A mutation • KMT2A rearrangement • KMT2D mutation • MLL rearrangement

3ms

Follicular lymphoma presenting with symptomatic bone involvement: a clinicopathological and molecular analysis of 16 cases. (PubMed, Mod Pathol)

All patients received rituximab +/- polychemotherapy as first-line treatment, and 7 local therapy (6 radiotherapy, 2 surgery)...FL may manifest as a localized or polyostotic bone disease. A minority represent PBL, while most reveal systemic disease.

3 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • BCL6 (B-cell CLL/lymphoma 6) • KMT2D (Lysine Methyltransferase 2D) • CD5 (CD5 Molecule) • TNFRSF14 (TNF Receptor Superfamily Member 14) • MME (Membrane Metalloendopeptidase)

KMT2D mutation • BCL6 rearrangement • BCL2 rearrangement

Rituxan (rituximab)

3ms

Feasibility of Circulating Tumor DNA Analysis in Patients with Follicular Lymphoma. (PubMed, Cancer Res Treat)

Forty samples from patients receiving rituximab-containing immunochemotherapy were analyzed...Analysis of ctDNA mutations in plasma at diagnosis might help predict outcome of disease, while analysis during follow-up may help to monitor disease status of patients with advanced FL. However, the feasibility of ctDNA measurement must be improved in order for it to become an appropriate and clinically relevant test in FL patients.

3 months ago

Journal • Tumor mutational burden • Circulating tumor DNA

TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • KMT2D (Lysine Methyltransferase 2D) • KMT2C (Lysine Methyltransferase 2C) • CREBBP (CREB binding protein)

TP53 mutation • KMT2D mutation • CREBBP mutation • KMT2C mutation

Rituxan (rituximab)

3ms

Study of Modified Atkins Diet in Kabuki Syndrome (clinicaltrials.gov)

P1, N=15, Active, not recruiting, Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | Recruiting --> Active, not recruiting

3 months ago

Enrollment closed

KMT2D (Lysine Methyltransferase 2D)

KMT2D mutation

4ms

Genetic and prognostic analysis of blastoid and pleomorphic mantle cell lymphoma: a multicenter analysis in China. (PubMed, Ann Hematol)

First-line high-dose cytosine arabinoside exposure obtained survival benefits in these populations, and BTKi combination therapy as the front-line treatment had somewhat improvement in survival with no significant difference in the statistic...Patients with POD12 displayed a distinct mutation profile and a poor prognosis. New therapeutic drugs and clinical trials for B/P-MCL need to be further explored.

4 months ago

Journal

TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • NOTCH1 (Notch 1) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • NOTCH2 (Notch 2) • CREBBP (CREB binding protein) • FAT1 (FAT atypical cadherin 1) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

TP53 mutation • ATM mutation • CDKN2A mutation • KMT2D mutation

cytarabine

4ms

Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment. (PubMed, Proc Natl Acad Sci U S A)

Using a preclinical carcinogen model of bladder cancer in mouse, we demonstrate that truncated cytoplasmic MLL4 predicts response to targeted metabolic inhibition therapy for bladder cancer and could be developed as a biomarker for KMT2D-mutated cancers. We also highlight the broader potential for prognosis, patient stratification and treatment decision-making based on KMT2D mutation status in MLL4 truncation-relevant diseases, including human cancers and Kabuki Syndrome.

4 months ago

Journal

KMT2D (Lysine Methyltransferase 2D)

KMT2D mutation • MLL mutation

4ms

Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy. (PubMed, Drug Des Devel Ther)

We conducted an unprecedented work via a WES-based approach and provided preliminary insights into H101 treatment-induced genetic aberrations in which some genes (TTN, KMT2D, ALDOA, DNAH7, ADAP1, PTPN23, and THEMIS2) could be considered potential therapeutic targets of H101-containing treatment in cervical carcinoma. Moreover, the therapy-associated characteristics such as clonal evolution and a mutational signature may warrant further evaluation of H101 in clinical settings for treating cervical carcinoma.

4 months ago

Journal • Tumor mutational burden • MSi-H Biomarker • Metastases

TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • KMT2D (Lysine Methyltransferase 2D) • ALDOA (Aldolase Fructose-Bisphosphate A) • THEMIS2 (Thymocyte Selection Associated Family Member 2)

KMT2D mutation • TTN mutation • PTPN2 mutation

Oncorine (recombinant human adenovirus type 5)

5ms

Exploring the molecular features and genetic prognostic factors of pulmonary high-grade neuroendocrine carcinomas. (PubMed, Hum Pathol)

IHC for Rb was reliable for predicting LCNEC molecular subtypes, indicating its clinical value. NCOR2 and SPTA1 alterations were identified as prognostic factors that may provide therapeutic targets for patients with NEC.

5 months ago

Journal

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • NOTCH1 (Notch 1) • KMT2D (Lysine Methyltransferase 2D) • LRP1B (LDL Receptor Related Protein 1B) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • FAT3 (FAT Atypical Cadherin 3) • NCOR2 (Nuclear Receptor Corepressor 2) • SPTA1 (Spectrin Alpha) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • SFTPA1 (Surfactant Protein A1)

TP53 mutation • EGFR mutation • NOTCH1 mutation • KMT2D mutation • HIF1A expression

5ms

Gene mutation analysis of oral submucous fibrosis cancerization in Hainan Island. (PubMed, PeerJ)

The mutation frequency of FLT4 gene was significantly higher than that of OSCC group (P < 0.05). FLT4 gene may be related to OSF cancerization and is expected to be an early diagnostic biomarker for OSF cancerization.

5 months ago

Journal • BRCA Biomarker

TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • HRAS (Harvey rat sarcoma viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • NF1 (Neurofibromin 1) • KMT2A (Lysine Methyltransferase 2A) • MLH1 (MutL homolog 1) • KMT2D (Lysine Methyltransferase 2D) • FGFR4 (Fibroblast growth factor receptor 4) • MSH2 (MutS Homolog 2) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • APC (APC Regulator Of WNT Signaling Pathway) • FLT4 (Fms-related tyrosine kinase 4) • FLCN (Folliculin)

TP53 mutation • PIK3CA mutation • PTEN mutation • KMT2D mutation • APC mutation • MLH1 mutation

5ms

Clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in Chinese population with mismatch repair deficient urothelial carcinoma: a real-world study. (PubMed, Front Immunol)

Positive PD-L1 expression was found in 20% cases, but some patients positively responded to immunotherapy despite negative PD-L1 expression. Our findings provide valuable insights into the characteristics of dMMR UC in the Chinese population and highlights the relevance of genetic testing and immunotherapy biomarkers for treatment decisions.

5 months ago

Journal • Real-world evidence • Mismatch repair • Tumor mutational burden • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Real-world

TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • KMT2D (Lysine Methyltransferase 2D) • KMT2C (Lysine Methyltransferase 2C)

PD-L1 expression • TMB-H • MSI-H/dMMR • PD-L1 negative • KMT2D mutation

5ms

Mutational Landscape of Diffuse Large B-Cell Lymphoma (DLBCL) in Mexican Patients (ASH 2023)

Inclusion criteria: patients > 18 years, diagnosis of DLBCL, without previous treatment and candidate to be treated with RCHOP... This is the first approach to describe the genomic landscape in Latino-american population. The presence of EZH2 and KMT2 mutations were more frequent in female patients with mediastinal and bulky disease. After multivariate analysis, only the presence of EZH2 mutations was the only genomic factor influencing on OS.

5 months ago

Clinical

TP53 (Tumor protein P53) • ARID1A (AT-rich interaction domain 1A) • NOTCH1 (Notch 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • KMT2D (Lysine Methyltransferase 2D) • CREBBP (CREB binding protein)

TP53 mutation • MYD88 mutation • KMT2D mutation • EZH2 mutation

Rituxan (rituximab)

5ms

Genetic Mutations in Primary Refractory Diffuse Large B-Cell Lymphoma: Next Generation Sequencing Analysis (ASH 2023)

About 60-70% of DLBCL patients could be cured with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP), while the other patients show chemo-refractory or relapse of disease and have poor prognosis. ConclusionCIITA, RASSF54, STAT6, SYK were frequently mutated in primary refractory DLBCL in this study. Because of the small sample size, however, the prognostic significance of these mutations needed to be studied in further researches.

5 months ago

Next-generation sequencing • IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • KMT2D (Lysine Methyltransferase 2D) • SYK (Spleen tyrosine kinase) • PIM1 (Pim-1 Proto-Oncogene) • STAT6 (Signal transducer and activator of transcription 6) • PCLO (Piccolo Presynaptic Cytomatrix Protein)

KMT2D mutation

Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine

5ms

Pucotenlimab in patients with advanced mismatch repair-deficient or microsatellite instability-high solid tumors: A multicenter phase 2 study. (PubMed, Cell Rep Med)

Pucotenlimab is an effective treatment option for previously treated advanced dMMR/MSI-H solid tumors, and the predictive value of KMT2D mutation warrants further research. This study is registered with ClinicalTrials.gov: NCT03704246.

5 months ago

P2 data • Journal • Mismatch repair • Microsatellite instability • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Metastases

MSI (Microsatellite instability) • KMT2D (Lysine Methyltransferase 2D)

MSI-H/dMMR • KMT2D mutation

Puyouheng (pucotenlimab)

5ms

DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients. (PubMed, Diagn Pathol)

DDR gene mutations are associated with tumor metastasis, TMB, and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients.

5 months ago

Journal • Tumor mutational burden • IO biomarker • Metastases

EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • KMT2D (Lysine Methyltransferase 2D) • FANCG (FA Complementation Group G)

TP53 mutation • KRAS mutation • TMB-H • ALK mutation • KMT2D mutation • FANCG mutation

6ms

Genomic Landscape of Malignant Phyllodes Tumors Identifies Subsets for Targeted Therapy (SABCS 2023)

Additionally, one MPT sample harbored a pathogenic NTRK1 fusion (TPM4:NTRK1), and treatment with larotrectinib for over 16 months suggests a clinical response to therapy... Our study demonstrates the importance of employing next generation sequencing (NGS) in MPTs to detect actionable genomic alterations. To effectively analyze fusions, an NGS panel that include RNA sequencing is recommended, considering the occurrence of NTRK1 fusion reported herein. Although HER2 transcriptional expression was low, further investigations examining HER2 IHC in PTs are still necessary.

6 months ago

Tumor mutational burden • PD(L)-1 Biomarker • MSi-H Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • RB1 (RB Transcriptional Corepressor 1) • NF1 (Neurofibromin 1) • KMT2D (Lysine Methyltransferase 2D) • TPM4 (Tropomyosin 4)

PD-L1 expression • EGFR mutation • MSI-H/dMMR • BRAF mutation • HER-2 negative • PIK3CA mutation • NTRK1 fusion • HER-2 expression • NF1 mutation • KMT2D mutation

VENTANA PD-L1 (SP142) Assay • MI Tumor Seek™

Vitrakvi (larotrectinib)

6ms

Emergence of Highly-Plastic B Cell States Cooperates with Early Immune Microenvironment Remodeling to Drive Follicular Lymphomagenesis (ASH 2023)

In conclusion, our results provide a high-resolution view of events spanning FL progression and indicate a major role of early TME remodeling in establishing a suitable niche for progression. Early intervention aimed to target the B cell-tumor microenvironment interactions driving intra-tumoral heterogeneity may represent a promising therapeutic avenue against early disease and prevention of FL recurrence.

6 months ago

IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CD8 (cluster of differentiation 8) • KMT2D (Lysine Methyltransferase 2D) • CD4 (CD4 Molecule)

BCL2 overexpression • KMT2D mutation • BCL2 expression • BCL2 mutation

6ms

Phase II Trial of Ibrutinib in Previously Untreated High-Risk Smoldering Mantle Cell Lymphoma (ASH 2023)

Ibrutinib demonstrated significant efficacy with manageable toxicities in previously untreated patients with high-risk smoldering MCL.

6 months ago

P2 data

TP53 (Tumor protein P53) • KMT2D (Lysine Methyltransferase 2D) • BIRC3 (Baculoviral IAP repeat containing 3)

TP53 mutation • TP53 wild-type • KMT2D mutation • MYC positive

Imbruvica (ibrutinib)

6ms

Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma (ASH 2023)

Low mRNA expression of PHLPP2 predicted poor prognosis (p=.03) and engineered PHLPP2 loss showed enhanced PI(3)K activation and FOXO1 inactivation in CD4+ T-cells in-vitro. Thus, we defined the genomic landscape for AITL, which is largely characterized by epigenetic alterations, TCR signaling and PI3K/AKT dysregulation, which may be amenable for therapeutic targeting.

6 months ago

IO biomarker • Omic analysis

PTEN (Phosphatase and tensin homolog) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • CD20 (Membrane Spanning 4-Domains A1) • DNMT3A (DNA methyltransferase 1) • JAK2 (Janus kinase 2) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CD163 (CD163 Molecule) • CD4 (CD4 Molecule) • JAK3 (Janus Kinase 3) • RHOA (Ras homolog family member A) • CD68 (CD68 Molecule) • PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) • SOCS1 (Suppressor Of Cytokine Signaling 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • VAV1 (Vav Guanine Nucleotide Exchange Factor 1) • HLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2) • PHLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2)

IDH2 mutation • DNMT3A mutation • TET2 mutation • KMT2D mutation • JAK3 mutation • IDH2 R172 • RHOA G17V

6ms

A Multi-Omic Study Unveils a Clonal Population of TET2-Mutated Infiltrating T-Cells in Germinal Center B Cell Lymphomas (DLBCL and FL) (ASH 2023)

Moreover, our findings support the critical role of the tumor microenvironment for the persistence and development of the tumor clone. The finding of a TET2 mutated clone in the infiltrating T cells of all the patients is particularly noteworthy, as it may suggest the possible presence of clonal lymphopoiesis.

6 months ago

Clinical • PD(L)-1 Biomarker • IO biomarker

ATM (ATM serine/threonine kinase) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • LAG3 (Lymphocyte Activating 3) • B2M (Beta-2-microglobulin) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • NOTCH2 (Notch 2) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD4 (CD4 Molecule) • CD5 (CD5 Molecule) • GNA13 (G Protein Subunit Alpha 13) • RHOA (Ras homolog family member A) • MME (Membrane Metalloendopeptidase)

TET2 mutation • KMT2D mutation • EZH2 mutation • CD8 expression • LAG3 expression • CD4 expression

6ms

Mutations in Histone Lysine Methyltransferase Genes Are Associated with Autoimmune Cytopenias (ASH 2023)

Conclusion We report for the first time that patients with autoimmune cytopenias have a high frequency of variants in MT genes. Median allelic frequency close to 50% suggests potential germline predisposition to immune dysregulation and autoimmunity however further studies are needed to better understand the impact of these observations.

6 months ago

Epigenetic controller

KMT2A (Lysine Methyltransferase 2A) • KMT2D (Lysine Methyltransferase 2D) • KMT2C (Lysine Methyltransferase 2C) • KDM6A (Lysine Demethylase 6A)

KMT2D mutation • KMT2C mutation • KDM6A mutation • MLL3 mutation

6ms

Longitudinal Noninvasive Surveillance & Fragmentomic Characterization of Follicular Lymphoma (ASH 2023)

Depth of response was similar between rituximab monotherapy and cytotoxic regimens, with median -2.2 log10 fold change from baseline...Frequent detectable MRD in radiographic remission suggests that integrating molecular surveillance may augment serial imaging in the long-term management of FL. Simultaneous inferred gene expression from FL cfDNA appears to hold promise, including for noninvasive detection of transformation.

6 months ago

IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6) • KMT2D (Lysine Methyltransferase 2D) • CREBBP (CREB binding protein)

TP53 mutation • KMT2D mutation • CREBBP mutation

Rituxan (rituximab)

6ms

CD58 Genetic Alterations and Its Contribution to Upregulation of PD-L1 and IDO Via LYN/CD22/SHP1 Axis in DLBCL (ASH 2023)

Patients with CD58 mutation, copy number loss or low expression exhibited lower complete response rates following first-line R-CHOP therapy, as well as significantly poorer PFS and OS... Our study comprehensively characterized CD58 genetic alterations in DLBCL. We demonstrated that CD58 downregulation or mutation led to upregulation of PD-L1 and IDO expression mainly by regulating the LYN/CD22/SHP1 axis. Moreover, we explored strategies to directly activate CD2 co-stimulatory signaling or in combination with immune checkpoint inhibitors to address the diverse effects of CD58 alterations.

6 months ago

PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • JAK2 (Janus kinase 2) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD8 (cluster of differentiation 8) • KMT2D (Lysine Methyltransferase 2D) • CD79B (CD79b Molecule) • CD22 (CD22 Molecule) • CD4 (CD4 Molecule) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • CD58 (CD58 Molecule) • CD2 (CD2 Molecule)

PD-L1 expression • MYD88 mutation • KMT2D mutation • CD79B mutation • IDO1 expression • CD58 mutation

Rituxan (rituximab)

6ms

Plasma Circulating Tumor DNA (ctDNA) as an Alternative to Tissue DNA for Genotyping of DLBCL: Results from the POLARIX Study (ASH 2023)

Introduction: In the POLARIX study (NCT03274492), polatuzumab vedotin in combination with rituximab plus cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) demonstrated prolonged progression-free survival (PFS) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL; Tilly et al. Our analyses demonstrated that the mutation landscape of ctDNA in DLBCL characterized by the AVENIO ctDNA NHL assay resembles that of tumor tissue determined by WES. Patients with molecular subtypes defined by WES or ctDNA had similar PFS outcomes. Overall, these findings support the use of plasma ctDNA as an alternative to tumor tissue for the genotyping of DLBCL.

6 months ago

IO biomarker • Circulating tumor DNA

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • NOTCH1 (Notch 1) • BCL6 (B-cell CLL/lymphoma 6) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • CD79B (CD79b Molecule) • NOTCH2 (Notch 2) • TNFAIP3 (TNF Alpha Induced Protein 3) • DCHS1 (Dachsous Cadherin-Related 1) • TP53BP1 (Tumor Protein P53 Binding Protein 1)

TP53 mutation • NOTCH1 mutation • TET2 mutation • KMT2D mutation • EZH2 mutation • MYD88 L265P • CD79B mutation • BCL6 rearrangement • CD79B mutation • NOTCH2 mutation • BCL2 rearrangement • BCL6 translocation • MYD88 L265P + CD79B mutation • TP53BP1 mutation • BCL2 translocation

Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Polivy (polatuzumab vedotin-piiq)

6ms

Concurrent Testing of Spatially Separated Tissue Samples and Circulating Tumor DNA Reveals Substantial Intra-Patient Genetic Heterogeneity in Relapsed/Refractory Follicular Lymphoma (ASH 2023)

Based on our results, R/R FL is characterized by remarkable intra-patient genetic heterogeneity. Although the founder clone harboring pathogenic KMT2D and CREBBP mutations can be identified in majority of the samples, expansion of tumor subclones between lymphoma sites confers divergent evolution, leaving genetic alterations unidentified during single-site based genetic testing. We also provide preliminary evidence, that multitarget high-throughput sequencing of cfDNA can uncover spatially restricted subclones that play a role in disease progression in R/R FL and that pretreatment ctDNA level might have a predictive value in the relapsed setting of FL.

6 months ago

Clinical • Circulating tumor DNA

IGH (Immunoglobulin Heavy Locus) • KMT2D (Lysine Methyltransferase 2D) • CREBBP (CREB binding protein) • TNFRSF14 (TNF Receptor Superfamily Member 14) • STAT6 (Signal transducer and activator of transcription 6)

KMT2D mutation • CREBBP mutation

6ms

Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma (clinicaltrials.gov)

P1/2, N=50, Recruiting, City of Hope Medical Center | Trial completion date: May 2025 --> Feb 2026 | Trial primary completion date: May 2025 --> Feb 2026

6 months ago

Trial completion date • Trial primary completion date

TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • KMT2D (Lysine Methyltransferase 2D) • NOTCH2 (Notch 2) • SOX11 (SRY-Box Transcription Factor 11) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

TP53 mutation • Chr t(11;14) • KMT2D mutation • CCND1 expression • SOX11 expression

Venclexta (venetoclax) • lenalidomide • Gazyva (obinutuzumab) • Columvi (glofitamab-gxbm)

6ms

Co-mutation of TP53 and TTN is Correlated with the Efficacy of Immunotherapy in Lung Squamous Cell Carcinoma. (PubMed, Comb Chem High Throughput Screen)

The LUSC patients with TP53 and TTN co-mutation had higher TMB levels and better response to immunotherapy. The TP53 and TTN co-mutation is a promising novel biomarker to assist LUSC immunotherapy evaluation.

6 months ago

Journal • Tumor mutational burden • IO biomarker

TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • KMT2D (Lysine Methyltransferase 2D) • LRP1B (LDL Receptor Related Protein 1B) • MUC16 (Mucin 16, Cell Surface Associated) • TTN (Titin) • USH2A (Usherin) • CSMD3 (CUB And Sushi Multiple Domains 3) • NAV3 (Neuron Navigator 3 ) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) • ZFHX4 (Zinc Finger Homeobox 4)

TP53 mutation • TMB-H • KMT2D mutation

6ms

Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma. (PubMed, Med Oncol)

KMT2D could be a potential therapeutic target. Moreover, TP53 could be a potential prognosis marker for mucosal melanoma.

6 months ago

Journal • Tumor mutational burden

BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • NRAS (Neuroblastoma RAS viral oncogene homolog) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • NF1 (Neurofibromin 1) • KMT2D (Lysine Methyltransferase 2D) • MUC16 (Mucin 16, Cell Surface Associated)

TP53 mutation • BRAF mutation • KIT mutation • KMT2D mutation

6ms

MOLECULAR CHARACTERIZATION OF STAGE I, GRADE 3 ENDOMETRIOID ENDOMETRIAL CANCER (IGCS 2023)

Seventy-five patients were identified. Unlike stage I, grade 1 EECs, which are mostly of copy number (CN)-low molecular subtype, most of our stage I, grade 3 EECs were of POLE (25/75, 33%) or microsatellite instability (MSI)-high (24/75, 32%) molecular subtypes; 20% (15/75) were CN-high and 15% (11/75) CN-low. Patients with MSI-high EECs, compared to other subtypes, were more likely to have deep myometrial invasion (p=0.02) and to have received chemotherapy (p=0.01).

6 months ago

MSi-H Biomarker

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MSI (Microsatellite instability) • PTEN (Phosphatase and tensin homolog) • ARID1A (AT-rich interaction domain 1A) • POLE (DNA Polymerase Epsilon) • KMT2D (Lysine Methyltransferase 2D) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4)

MSI-H/dMMR • PTEN mutation • POLE mutation • KMT2D mutation • MET mutation • PIK3R1 mutation

6ms

Ibrutinib in Treating Participants With Untreated High Risk Smoldering Mantle Cell Lymphoma (clinicaltrials.gov)

P2, N=20, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Feb 2025 --> Feb 2026 | Trial primary completion date: Feb 2024 --> Feb 2026

6 months ago

Trial completion date • Trial primary completion date

TP53 (Tumor protein P53) • CD20 (Membrane Spanning 4-Domains A1) • CCND1 (Cyclin D1) • KMT2D (Lysine Methyltransferase 2D) • NOTCH2 (Notch 2) • BIRC3 (Baculoviral IAP repeat containing 3) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2)

TP53 mutation • CD20 positive • TP53 wild-type • KMT2D mutation • MYC positive

Imbruvica (ibrutinib)

6ms

Application value of DNA damage repair variants in adjuvant therapy of triple negative breast cancer (PubMed, Zhonghua Zhong Liu Za Zhi)

PIK3CA mutation patients in TCb group had a worse prognosis than wild-type patients (5-year DFS were 71.4% and 88.1%, P=0.037), and KMT2D mutation patients in EC-T group had a worse prognosis than wild-type patients (5-year DFS were 76.9% and 86.8%, P=0.039). DDR gene variation is common in TNBC, more clinical studies are needed to prove whether DDR variation can serve as effective biomarkers for treatment with platinum.

6 months ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • HRD (Homologous Recombination Deficiency) • KMT2D (Lysine Methyltransferase 2D)

PIK3CA mutation • KMT2D mutation

6ms

KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis. (PubMed, iScience)

Loss of Kmt2d attenuates neural differentiation and shifts the transcriptional/chromatin landscape of primary and metastatic tumors toward a decrease in differentiation genes and tumor suppressors and an increase in genes/pathways implicated in advanced stage cancer and metastasis (TGFβ, Notch, Atoh1, Sox2, and Myc). Thus, secondary heterozygous KMT2D mutations likely have prognostic value for identifying SHH-MB patients prone to develop metastasis.

6 months ago

Journal

KMT2D (Lysine Methyltransferase 2D) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • SOX2 • TGFB1 (Transforming Growth Factor Beta 1) • ATOH1 (Atonal BHLH Transcription Factor 1)

KMT2D mutation

7ms

Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms. (PubMed, Leukemia)

In BCL2 + FL mutations in KMT2D, BCL2, ABL2, IGLL5 and ARID1A were enriched, while STAT6 mutations more frequently occurred in BCL2- FL. Although the landscape of lFL and sFL showed overlapping features, molecular profiling revealed novel insights and identified gains in 18q21 as prognostic marker in lFL.

7 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • ARID1A (AT-rich interaction domain 1A) • KMT2D (Lysine Methyltransferase 2D) • ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase) • STAT6 (Signal transducer and activator of transcription 6) • IGLL5 (Immunoglobulin Lambda Like Polypeptide 5)

ARID1A mutation • KMT2D mutation • BCL2 positive • BCL2 translocation