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    GENE:

    KLK12 (Kallikrein Related Peptidase 12)

    i
    Other names: KLK12, Kallikrein Related Peptidase 12, KLK-L5, Kallikrein-Like Protein 5, Kallikrein-12, KLKL5, Kallikrein 12
    Associations

    News

    Trials
    1year
    Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer. (PubMed, Sci Rep)
    Therefore, we further validated their expression in cells and tissues using qPCR. In summary, we developed a prognostic marker associated with inflammatory genes to provide new directions for subsequent studies and to help clinicians assess the prognosis of CRC patients as well as to develop personalized treatment strategies.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • PD-1 (Programmed cell death 1) • PD-L2 (Programmed Cell Death 1 Ligand 2) • GDF15 (Growth differentiation factor 15) • IGF1 (Insulin-like growth factor 1) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • FOXD1 (Forkhead Box D1) • NXPH1 (Neurexophilin 1) • KLK12 (Kallikrein Related Peptidase 12)
    almost2years
    Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis. (PubMed, Int J Mol Sci)
    IDCP sites also showed increased hypoxia markers HIF1A, BNIP3L, PDK1, and POGLUT1; decreased fibroblast markers COL1A2, DCN, and LUM; and decreased immune cell markers CCR5 and FCGR3A. Overall, these findings indicate that the hypoxic tumor microenvironment and reduced recruitment of fibroblasts and immune cells, which reflect morphological features of IDCP, may influence the aggressiveness of high-grade prostate cancer.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • BNIP3L (BCL2 Interacting Protein 3 Like) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • MYO16 (Myosin XVI) • MUC6 (Mucin 6) • SLC2A1 (Solute Carrier Family 2 Member 1) • KLK12 (Kallikrein Related Peptidase 12)
    almost2years
    A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients. (PubMed, Curr Med Chem)
    We used bioinformatics to determine a new, robust sixteen-gene signature. We also found that this signature's prognostic ability was closely related to the resting mast cell infiltration of LUAD patients.
    Journal • Gene Signature • Immune cell
    |
    CD20 (Membrane Spanning 4-Domains A1) • EREG (Epiregulin) • CCR2 (C-C Motif Chemokine Receptor 2) • CYP4B1 (Cytochrome P450 Family 4 Subfamily B Member 1) • MS4A1 (Membrane Spanning 4-Domains A1) • TAP1 (Transporter 1) • HOXB9 (Homeobox B9) • S100P (S100 calcium binding protein P) • KLK12 (Kallikrein Related Peptidase 12)
    over2years
    Early detection of squamous cell carcinoma of the oral tongue using multidimensional plasma protein analysis and interpretable machine learning. (PubMed, J Oral Pathol Med)
    Using multidimensional plasma protein analysis and interpretable ML, we outline a systematic approach for early detection of SCCOT before the appearance of clinical signs.
    Journal • Machine learning
    |
    IL10 (Interleukin 10) • KLK12 (Kallikrein Related Peptidase 12)