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    GENE:

    KLHL23 (Kelch Like Family Member 23)

    i
    Other names: KLHL23, Kelch Like Family Member 23, Kelch-Like Protein 23, Kelch-Like 23 (Drosophila), Kelch-Like 23, FLJ37812, MGC22679, MGC2610, DITHP
    Associations

    News

    Trials
    6ms
    KLHL23 and RhoGDI coordinate CDC42 inactivation ensuring membrane homeostasis. (PubMed, Nat Chem Biol)
    Fluorescence resonance energy transfer assays reveal that KLHL23 and RhoGDI coordinately inactivate CDC42 in a spatiotemporal manner. These findings highlight the biological and clinical relevance of the KLHL23/RhoGDI-CDC42 axis, presenting new avenues for therapeutic exploration.
    Journal
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    CDC42 (Cell Division Cycle 42) • KLHL23 (Kelch Like Family Member 23)
    1year
    Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis. (PubMed, Aging (Albany NY))
    Notably, KLHL23 levels correlated with survival in cancers such as hepatocellular carcinoma and low-grade glioma. The study also highlighted how reduced KLHL23 expression is linked to increased immune activity and sensitivity to chemotherapy, suggesting its potential as a biomarker for cancer prognosis and treatment responsiveness.
    Journal
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    KLHL23 (Kelch Like Family Member 23)
    over2years
    Identification of cancer-associated fibroblasts signature for predicting the prognosis and immunotherapy response in hepatocellular carcinoma. (PubMed, Medicine (Baltimore))
    Moreover, high risk score indicated a lower IC50 value of 5-fluorouracil, camptothecin, cisplatin, docetaxel, gemcitabine, paclitaxel, afatinib, crizotinib, dasatinib, erlotinib, erlotinib, gefitinib, lapatinib, and osimertinib in HCC. Our study develops a novel FRPS HCC. The FRPS acts as a risk factor for the prognosis of HCC patients and it can predict the immunotherapy benefits of HCC patients.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
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    TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • SERPINE1 (Serpin Family E Member 1) • KLHL23 (Kelch Like Family Member 23) • CD151 (CD151 Molecule)
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    TMB-H
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    cisplatin • Xalkori (crizotinib) • Tagrisso (osimertinib) • erlotinib • Gilotrif (afatinib) • dasatinib • gefitinib • gemcitabine • paclitaxel • docetaxel • 5-fluorouracil • lapatinib
    over3years
    Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells. (PubMed, Aging (Albany NY))
    Moreover, knockdown of PHOSPHO2-KLHL23, TSNAX-DISC1, TRIM39 and RPP21 diminished cell proliferation and migration increased by SOF in OR-6 and Huh 7.5.1 cells. In conclusion, SOF-upregulated genes promoted HCC cell proliferation and migration, which might be associated with the development of HCC.
    Journal
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    KLHL23 (Kelch Like Family Member 23)