KLF4, EZF, GKLF, Kruppel-like factor 4 (gut)
LINC00852 is associated with poor prognosis in non-small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa-miR-145-5p/KLF4 axis. (PubMed, J Gene Med)
LINC00852 may be a prognostic biomarker for NSCLC. The epigenetic signaling pathway of LINC00852/hsa-miR-145-5p/KLF4 may be considered as a novel molecular target to fight NSCLC.
2 months ago
Clinical • Journal
KLF4 (Kruppel-like factor 4)
3,3'-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer. (PubMed, Front Oncol)
The level of KLF4 is correlated with the sensitivity of MCF-7 and T47D cells to PTX. DIM could enhance the antitumor efficacy of PTX on MCF-7 and T47D cells by regulating DNMT1 and KLF4.
3 months ago
KLF4 (Kruppel-like factor 4) • DNMT1 (DNA methyltransferase 1)
KLF4 overexpression • DNMT1 overexpression
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