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    BIOMARKER:

    KLF4 K409Q

    i
    Other names: KLF4, EZF, GKLF, Kruppel-like factor 4 (gut)
    Entrez ID:
    9314
    Related biomarkers:
    Expression
    Mutation
    11ms
    Genetic characterization and mutational profiling of foramen magnum meningiomas: a multi-institutional study. (PubMed, J Neurosurg)
    These findings provide important insights into the molecular genetics and clinicopathological characteristics of FM meningiomas. The identification of specific genetic alterations associated with tumor location, volume, calcification, histology, and sex at diagnosis may have implications for personalized treatment strategies in the future.
    Clinical • Journal
    |
    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • NF2 (Neurofibromin 2) • KLF4 (Kruppel-like factor 4)
    |
    PIK3CA mutation • PIK3CA H1047R • PIK3CA E545K • AKT1 E17K • NF2 mutation • AKT1 mutation • PIK3CA E545 • KLF4 K409Q
    over2years
    Mutated KLF4(K409Q) in meningioma binds STRs and activates FGF3 gene expression. (PubMed, iScience)
    In the KLF4-specific targets, the normally silent fibroblast growth factor 3 (FGF3) is activated. We demonstrated a neomorphic function of KLF4 in stimulating FGF3 transcription through binding to its promoter and in using short tandem repeats (STRs) located within the locus as enhancers.
    Journal
    |
    FGF3 (Fibroblast growth factor 3) • KLF4 (Kruppel-like factor 4) • FGF (Fibroblast Growth Factor)
    |
    KLF4 K409Q