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    BIOMARKER:

    KLF10 overexpression

    i
    Other names: KLF10, Kruppel Like Factor 10, TIEG1, Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1, TGFB-Inducible Early Growth Response Protein 1, Krueppel-Like Factor 10, EGR-Alpha, EGRA, TIEG, Zinc Finger Transcription Factor TIEG, TGFB Inducible Early Growth Response, Early Growth Response-Alpha, TIEG-1
    Entrez ID:
    7071
    Associations

    News

    Trials
    over2years
    Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors. (PubMed, J Biomed Sci)
    These results demonstrated a novel signaling pathway by which KLF10 modulates stem cell phenotypes in PDAC through transcriptionally regulating Notch signaling pathway. The elevation of KLF10 and suppression of Notch signaling may jointly reduce PDAC tumorigenesis and malignant progression.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • NOTCH3 (Notch Receptor 3) • TCF3 (Transcription Factor 3) • ELF3 (E74 Like ETS Transcription Factor 3) • PDX1 (Pancreatic And Duodenal Homeobox 1) • KLF10 (Kruppel Like Factor 10)
    |
    KLF10 overexpression
    |
    metformin
    almost4years
    KLF10 upregulates ACSM3 via the PI3K/Akt signaling pathway to inhibit the malignant progression of melanoma. (PubMed, Oncol Lett)
    Furthermore, silencing ACSM3 significantly reversed the effect of KLF10 overexpression on cell proliferation, invasion and migration, and ACSM3 knockdown increased the levels of phosphorylated (p)-PI3K and p-Akt compared with the levels in the Ov-KLF10 + sh-NC group. Overall, the present study suggested that KLF10 inhibited the proliferation, invasion and migration of melanoma cells by targeting ACSM3 via the PI3K/Akt signaling pathway.
    Journal
    |
    ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3) • KLF10 (Kruppel Like Factor 10)
    |
    KLF10 overexpression
    over4years
    Effect of Photodynamic Therapy on Gemcitabine-Resistant Cholangiocarcinoma in vitro and in vivo Through KLF10 and EGFR. (PubMed, Front Cell Dev Biol)
    KLF10 binds to EGFR promoter region to inhibit EGFR transcription. The KLF10/EGFR axis participates in the process of the inhibition of PDT on gemcitabine-resistant cholangiocarcinoma cells.
    Preclinical • Journal
    |
    EGFR (Epidermal growth factor receptor) • CCND1 (Cyclin D1) • CASP3 (Caspase 3) • KLF10 (Kruppel Like Factor 10)
    |
    EGFR overexpression • KLF10 overexpression
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    gemcitabine
    over4years
    Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency. (PubMed, Exp Mol Med)
    Activation of KLF10/SIRT6 signaling ameliorated the distant progression of PDAC.Clinical Trial Registration: ClinicalTrials.gov. identifier: NCT01666184.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • SIRT6 (Sirtuin 6) • KLF10 (Kruppel Like Factor 10)
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    KLF10 overexpression