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    BIOMARKER:

    KIT exon 17 mutation + KIT exon 18 mutation

    i
    Other names: KIT, KIT proto-oncogene receptor tyrosine kinase, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Entrez ID:
    3815
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    1year
    Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting. (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, M.D. Anderson Cancer Center
    New P2 trial
    |
    SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B)
    |
    KIT exon 17 mutation • SDHB mutation • KIT exon 17 mutation + KIT exon 18 mutation
    |
    imatinib • Stivarga (regorafenib)
    1year
    COMPREHENSIVE ANALYSIS OF THE GENOMIC LANDSCAPE AND CLINICAL BEHAVIOR IN GIST USING NEXT GENERATION SEQUENCING (NGS, MSK-IMPACT) (CTOS 2023)
    This study represents a one of the most comprehensive analyses of the genomic landscape and integration of genomic features with clinicopathologic attributes and survival outcome in GIST.
    Clinical • Tumor mutational burden • Next-generation sequencing
    |
    BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • PTEN (Phosphatase and tensin homolog) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • NF1 (Neurofibromin 1) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • TSC1 (TSC complex subunit 1) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • TNFRSF14 (TNF Receptor Superfamily Member 14) • GATA3 (GATA binding protein 3)
    |
    TP53 mutation • BRAF mutation • PIK3CA mutation • PTEN mutation • CDKN2A mutation • KIT exon 11 mutation • PDGFRA D842V • PDGFRA mutation • KIT exon 13 mutation • KIT exon 17 mutation • TSC1 mutation • KIT exon 17 mutation + KIT exon 18 mutation
    |
    MSK-IMPACT