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KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

News alerts, weekly reports and conference planners

KIR AA individuals possess strong inhibitory KIR alleles alongside HLA ligands that are protective against leukemia in the Chinese population. (PubMed, Front Genet)

These data suggest that KIR AA individuals possess strong inhibitory interactions of KIR alleles and HLA, arming KIR AA + NK cells to meditate stronger alloreactivity and cytotoxicity against leukemia cells with lowered HLA expression. Our findings may provide valuable insights into leukemia pathogenesis and better understanding of the immune mechanisms.

4 days ago

Journal

KIR3DL2 (Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Long Cytoplasmic Tail 2) • HLA-B (Major Histocompatibility Complex, Class I, B) • KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) • KIR2DL3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3) • KIR2DS4 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4) • KIR2DL1 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

19d

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. (PubMed, Eur J Immunol)

We identify an NCAM1 DRE that binds STAT3 in most NK cells, while identifying a genetic cohort that has motifs for binding repressive BLIMP1 at the DRE and resulting in less CD56 expression. Together, our findings reveal novel epigenetic and transcriptomic systems for the regulation of NK cell receptors driving NK cell cytotoxicity and diversity.

19 days ago

Journal • IO biomarker

STAT3 (Signal Transducer And Activator Of Transcription 3) • NCAM1 (Neural cell adhesion molecule 1) • PRDM1 (PR/SET Domain 1) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) • NKG2D (killer cell lectin like receptor K1)

Fifty Years of Natural Killer Cells: Milestones and Future Horizons. (PubMed, Scand J Immunol)

Translational developments described have bridged fundamental knowledge with clinical application, exemplified by current clinical studies of engineered NK cells, NK cell engagers and checkpoint blockade strategies. Together, these reflections underscored how five decades of NK cell research, rooted in seminal Scandinavian discoveries, have transformed from an unexpected observation into a cornerstone of immunotherapeutic potential.

1 month ago

Review • Journal

KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

2ms

Application of a novel branched-DNA assay to quantify killer immunoglobulin-like receptor (KIR) mRNA expression identifies tissue compartmentalization in naïve and SIV-infected rhesus macaques. (PubMed, J Immunol Methods)

Our findings reveal tissue-specific expression patterns of KIR genes that are differentially affected by chronic lentivirus infection, emphasizing the importance of compartmentalized KIR regulation in viral pathogenesis. This proof-of-concept study presents a reliable and scalable framework for the detailed characterization of the KIR gene repertoire in non-human primate models, providing a valuable alternative to traditional qPCR for profiling gene expression in complex tissues.

2 months ago

Journal

CD8 (cluster of differentiation 8) • KIR3DL2 (Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Long Cytoplasmic Tail 2) • ACACA (Acetyl-CoA Carboxylase Alpha) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

3ms

CD8+ Regulatory T Cells. (PubMed, Annu Rev Immunol)

Recent analyses of their T cell receptor repertoire, thymic differentiation, and mechanism of suppression are summarized. Identification of the human homolog of these cells has suggested new strategies for CD8+ Treg-dependent immunotherapy for autoimmune disease and cancers.

3 months ago

Review • Journal

CD4 (CD4 Molecule) • LY9 (Lymphocyte Antigen 9) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

3ms

TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity. (PubMed, J Immunother Cancer)

CD70 is a promising target for NK cell-based immunotherapy in AML. However, IFN-γ-dependent upregulation of HLA molecules on AML cells contributes to resistance to ADCC. These findings underscore the need for rationale combination strategies in clinical trials to overcome this inducible immune escape mechanism.

3 months ago

Journal • IO biomarker

IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD33 (CD33 Molecule) • CD70 (CD70 Molecule) • HLA-E (Major Histocompatibility Complex, Class I, E) • HLA-C (Major Histocompatibility Complex, Class I, C) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) • KLRC1 (Killer Cell Lectin Like Receptor C1)

PF-08046040

3ms

Do the expressions of HLA-G and killer cell immunoglobulin-like receptors change in colorectal cancer? (PubMed, Turk J Med Sci)

In conclusion, this study highlights the increased expression of both HLA-G and KIR markers in CRC patients, suggesting their potential as prognostic and predictive markers. Our findings also suggest that HLA-G and KIR molecules could represent valuable therapeutic targets for future cancer immunotherapy strategies.

3 months ago

Journal • IO biomarker

HLA-G (Major Histocompatibility Complex, Class I, G) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

4ms

Functional recovery of NK cells after T-cell replete haploidentical HSCT: delayed licensing and poor anti-AML activity. (PubMed, Blood Adv)

In this context, the combination of post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) effectively prevents graft-versus-host disease, but its impact on the reconstitution of peripheral blood natural killer (NK) cell subsets remains insufficiently characterized...These results indicate that, following h-HSCT with PTCy and ATG, NK cell subsets recover in number but fail to achieve early functional competence, particularly against myeloid targets. Strategies aiming at restoring mature NK cell functions warrant prospective investigations, especially in high-risk myeloid malignancies.

4 months ago

Journal

HLA-C (Major Histocompatibility Complex, Class I, C) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

cyclophosphamide

5ms

Antibody Mediated Inhibition of HLA/LILR Interactions Breaks Innate Immune Tolerance and Induces Antitumor Immunity. (PubMed, Cancer Immunol Res)

The mAbs also exert direct anti-tumor effects. These results suggest that activation of innate immunity via disruption of HLA/LILR interactions is a potent approach for control of both primary tumors and potentially tumor metastases.

5 months ago

Journal

KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) • KLRC1 (Killer Cell Lectin Like Receptor C1) • KLRD1 (Killer Cell Lectin Like Receptor D1)

5ms

Interplay of KIR2DL5, nitric oxide, and tobacco smoking in predisposition to bladder cancer. (PubMed, Front Cell Dev Biol)

KIR2DL5 is independently associated with BC, regardless of age, sex, or tobacco smoking status. While the immunological mechanisms remain unclear, enhanced nitric oxide production by immune effector cells may play a role in this association.

5 months ago

Journal

KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

6ms

Clinicopathological features and prognosis of aggressive natural killer-cell leukemia: an analysis of 27 cases (PubMed, Zhonghua Bing Li Xue Za Zhi)

Tumor cells exhibit significant morphological variation, and bone marrow infiltration patterns are diverse. Accurate recognition, early diagnosis, and timely chemotherapy are critical to improving the prognosis of patients with ANKL.

6 months ago

Retrospective data • Journal • IO biomarker

CD4 (CD4 Molecule) • NCAM1 (Neural cell adhesion molecule 1) • CD5 (CD5 Molecule) • GZMB (Granzyme B) • KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) • CD2 (CD2 Molecule) • KIR2DS4 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4) • B3GAT1 (Beta-1,3-Glucuronyltransferase 1) • KIR2DL1 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2)

6ms

Toggling of NKG2A expression drives functional specialization of iPSC-derived CAR NK cells. (PubMed, bioRxiv)

Finally, CRISPR-mediated ablation of NKG2A led to a spontaneous compensatory surface expression of CD94/NKG2C heterodimers, associated with enhanced IFN-g production and cytotoxic activity against target cells with forced high expression of single-chain B2m-HLA-E-peptide trimers. Our results indicate an education-independent functional maturation of iNK cells, characterized by potent effector programs coupled with a favorable early-stage transcriptional profile.

6 months ago

Journal • IO biomarker

IFNG (Interferon, gamma) • B2M (Beta-2-microglobulin) • GZMB (Granzyme B) • HLA-E (Major Histocompatibility Complex, Class I, E) • KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) • KLRC1 (Killer Cell Lectin Like Receptor C1) • NKG2D (killer cell lectin like receptor K1) • KLRD1 (Killer Cell Lectin Like Receptor D1)