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    BIOMARKER:

    KIM1 elevation

    i
    Other names: KIM1, Kidney injury molecule 1, HAVCR1, Hepatitis A virus cellular receptor 1, T-cell immunoglobulin mucin family member 1, TIM-1, T cell immunoglobin domain and mucin domain protein 1
    Entrez ID:
    26762
    Related biomarkers:
    Expression
    2ms
    Peficitinib Halts Acute Kidney Injury Via JAK/STAT3 and Growth Factors Immunomodulation. (PubMed, Eur J Pharmacol)
    Moreover, peficitinib decreased renal protein levels and gene expression of the pro-inflammatory cytokines; interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ). These findings suggest that peficitinib is helpful in halting AKI progression into chronic kidney disease through modulating JAK/STAT3 dependent inflammatory pathways and growth factors involved in normal glomerular function.
    Journal • Immunomodulating
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • FLT1 (Fms-related tyrosine kinase 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • KIM1 (Kidney injury molecule 1) • TGFB1 (Transforming Growth Factor Beta 1)
    |
    FLT1 expression • KIM1 elevation
    over3years
    Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma. (PubMed, Sci Rep)
    Finally, analysis of The Cancer Genome Atlas (TCGA) data revealed that elevated HAVCR1 mRNA expression in the two most common types of RCC, clear cell and papillary RCC, tumours correlated with significantly improved overall patient survival. Our findings reveal a novel role for KIM-1 in inhibiting metastasis of RCC and suggests that tumour-associated KIM-1 expression may be a favourable prognostic factor.
    Journal
    |
    KIM1 (Kidney injury molecule 1)
    |
    KIM1 elevation • KIM1 expression