KIF4A (Kinesin Family Member 4A)

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SeSA-HCPT: A dual-targeting agent that induces DNA damage and inhibits repair for castration-resistant prostate cancer therapy. (PubMed, iScience)

We developed SeSA-HCPT, a dual-targeting compound that links the topoisomerase I inhibitor hydroxycamptothecin (HCPT) with a selenium analog of the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid...In a PC-3 xenograft model, SeSA-HCPT significantly inhibited tumor growth relative to the combination treatment without observable systemic toxicity. These results nominate SeSA-HCPT as a promising dual-mechanism therapeutic candidate for advanced PCa.

6 days ago

Journal

RAD51 (RAD51 Homolog A) • KIF4A (Kinesin Family Member 4A)

Zolinza (vorinostat)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

3ms

KIF4A in disease pathogenesis and therapeutics: from molecular mechanisms to clinical translation. (PubMed, Biol Direct)

Finally, we outline major challenges to clinical translation, including its essential roles in mitosis and neuronal integrity, the need for tumor-selective delivery platforms, and incomplete understanding of its tissue-specific functions. Collectively, this review provides a unified mechanistic and translational framework for understanding KIF4A across human diseases, identifies key knowledge gaps, and proposes future research directions to enable safe and effective targeting of this biologically indispensable protein.

3 months ago

Review • Journal • IO biomarker

TGFB1 (Transforming Growth Factor Beta 1) • KIF4A (Kinesin Family Member 4A)

4ms

KIF4A Promotes Glioblastoma Malignant Progression and Transmission of Temozolomide Resistance in the Tumor Microenvironment via the HIF1A/VEGFA Axis. (PubMed, CNS Neurosci Ther)

This study provides a new idea for antagonizing temozolomide resistance in glioblastoma. KIF4A promotes malignant progression of glioblastoma and transmission of TMZ resistance in the tumor microenvironment through the HIF1A/VEGFA axis.

4 months ago

Journal

HIF1A (Hypoxia inducible factor 1, alpha subunit) • MMP9 (Matrix metallopeptidase 9) • KIF4A (Kinesin Family Member 4A)

temozolomide

5ms

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-Derived Midbody Remnant Proteome Following Epithelial-Mesenchymal Transition. (PubMed, Proteomics)

We identify several mesenchymal-enriched networks in MBRs associated with focal adhesion, cell matrix, kinase activity, and cell shape/organization, while epithelial-derived MBRs show enriched networks predominantly associated with mitochondrial (processing/transport), midbody, and plasma membrane annotation. Our study sheds light on the proteome architecture of MBRs following oncogenic H-Ras-induced EMT in cell transformation: collectively, our data informs ongoing efforts to delineate oncogenic drivers of cancer initiation, progression, and metastasis.

5 months ago

Journal

HRAS (Harvey rat sarcoma viral oncogene homolog) • CDH1 (Cadherin 1) • CD73 (5'-Nucleotidase Ecto) • PLK1 (Polo Like Kinase 1) • EPCAM (Epithelial cell adhesion molecule) • NT5E (5'-Nucleotidase Ecto) • CDH2 (Cadherin 2) • CEP55 (Centrosomal Protein 55) • KIF23 (Kinesin Family Member 23) • KIF4A (Kinesin Family Member 4A) • MMP14 (Matrix Metallopeptidase 14)

5ms

Machine Learning-Based Diagnostic Model for Accurate Prediction of Breast Cancer Using Immunohistochemical Images. (PubMed, Cancer Biother Radiopharm)

However, the combined diagnostic efficacy of TK1 and UBE2C increased to 99%. This study highlights the potential of machine learning algorithms in the classification and diagnosis of breast cancer pathology images, emphasizing the importance of integrating bioinformatics with machine learning to enhance early diagnosis and facilitate personalized treatment strategies for breast cancer.

5 months ago

Journal

KIF4A (Kinesin Family Member 4A) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

6ms

Construction and Validation of a Novel Prognostic Model Based on Cervical Cancer-Related Genes. (PubMed, Reprod Sci)

APOD is a prognostic biomarker for cervical cancer, and the prognostic model constructed by identified cervical cancer-related genes can successfully distinguish the prognosis of patients with cervical cancer.

6 months ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • RAD54L (DNA Repair And Recombination Protein RAD54) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • MYBL2 (MYB Proto-Oncogene Like 2) • CDC45 (Cell Division Cycle 45) • CEP55 (Centrosomal Protein 55) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • RFC4 (Replication Factor C Subunit 4) • DNA2 (DNA Replication Helicase/Nuclease 2) • SPAG5 (Sperm Associated Antigen 5)

7ms

KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance. (PubMed, Mol Carcinog)

In addition, KIF4A induced epithelial-mesenchymal transition in GBM cells, which synergistically promoted TMZ resistance.The present study elucidates a novel mechanism of TMZ resistance in glioblastoma through the CHMP4B/GPX4 axis. Based on these findings, targeting KIF4A may offer a potential new strategy against GBM.

7 months ago

Journal

GPX4 (Glutathione Peroxidase 4) • KIF4A (Kinesin Family Member 4A)

temozolomide

7ms

Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenance. (PubMed, Eur J Med Res)

This study identified eight TM-related hub genes with prognostic significance in HCC and established a novel TM-related gene signature. Furthermore, we validated KPNA2 as a key regulator of telomere maintenance and tumor progression in HCC, suggesting it as a potential therapeutic target for improving clinical management of HCC.

7 months ago

Journal

PLK1 (Polo Like Kinase 1) • RAD54L (DNA Repair And Recombination Protein RAD54) • AURKB (Aurora Kinase B) • FOXM1 (Forkhead Box M1) • CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) • CDCA8 (Cell Division Cycle Associated 8) • IRAK1 (Interleukin 1 Receptor Associated Kinase 1) • KIF4A (Kinesin Family Member 4A) • KPNA2 (Karyopherin Subunit Alpha 2)